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- Strawbridge, RJ, et al.
(författare)
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Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness
- 2016
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 65:10, s. 2888-2899
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Tidskriftsartikel (refereegranskat)abstract
- Type 2 diabetes and cardiovascular disease are complex disorders involving metabolic and inflammatory mechanisms. Here we investigated whether sCD93, a group XIV c-type lectin of the endosialin family, plays a role in metabolic dysregulation or carotid intima-media thickness (IMT). Although no association was observed between sCD93 and IMT, sCD93 levels were significantly lower in subjects with type 2 diabetes (n = 901, mean ± SD 156.6 ± 40.0 ng/mL) compared with subjects without diabetes (n = 2,470, 164.1 ± 44.8 ng/mL, P < 0.0001). Genetic variants associated with diabetes risk (DIAGRAM Consortium) did not influence sCD93 levels (individually or combined in a single nucleotide polymorphism score). In a prospective cohort, lower sCD93 levels preceded the development of diabetes. Consistent with this, a cd93-deficient mouse model (in addition to apoe deficiency) demonstrated no difference in atherosclerotic lesion development compared with apoe−/− cd93-sufficient littermates. However, cd93-deficient mice showed impaired glucose clearance and insulin sensitivity (compared with littermate controls) after eating a high-fat diet. The expression of cd93 was observed in pancreatic islets, and leaky vessels were apparent in cd93-deficient pancreases. We further demonstrated that stress-induced release of sCD93 is impaired by hyperglycemia. Therefore, we propose CD93 as an important component in glucometabolic regulation.
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- Ossiannilsson, Ebba, et al.
(författare)
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Web 2.0 to Encourage Usability of GIS (Geographical Information Systems) in Society – the eGIS+ Project
- 2009
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Ingår i: Research, Reflections and Innovations in Integrating ICT in Education. - 9788469217900 - 9788469217887 ; 2, s. 1131-1135
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- GIS applications are nowadays used in nearly every area of society and the need for GIS competence is therefore increasing over all. Micro-training and open educational resources are important concepts to reach new target groups, not least from a higher education perspective. The use of Web 2.0 creates possibilities for a more user friendly approach and for broader outreach. The eGIS+ project addresses the question of how to capture the interest of children and new groups for GIS and to offer GIS competence with a high level of flexibility in time, space and study pace.
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