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1.	Bryois, J., et al. (author) Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease 2020 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493 Journal article (peer-reviewed)abstract Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
2.	Walton, E, et al. (author) Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa 2019 In: Molecular neurobiology. - : Springer Science and Business Media LLC. - 1559-1182 .- 0893-7648. ; 56:7, s. 5146-5156 Journal article (peer-reviewed)
3.	Duncan, L, et al. (author) Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa 2017 In: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 174:9, s. 850-858 Journal article (peer-reviewed)
4.	Yao, SY, et al. (author) Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches 2019 In: Biological psychiatry. - : Elsevier BV. - 1873-2402 .- 0006-3223. ; 86:8, s. 577-586 Journal article (peer-reviewed)
5.	Boraska, V, et al. (author) A genome-wide association study of anorexia nervosa 2014 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 19:10, s. 1085-1094 Journal article (peer-reviewed)
6.	Demontis, D, et al. (author) Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:1, s. 63- Journal article (peer-reviewed)
7.	Watson, HJ, et al. (author) Common Genetic Variation and Age of Onset of Anorexia Nervosa 2022 In: Biological psychiatry global open science. - : Elsevier BV. - 2667-1743. ; 2:4, s. 368-378 Journal article (peer-reviewed)
8.	Huckins, LM, et al. (author) Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa 2018 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 23:9, s. 1969- Journal article (peer-reviewed)
9.	Hinney, A, et al. (author) Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index 2017 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 22:2, s. 192-201 Journal article (peer-reviewed)
10.	Yilmaz, Z, et al. (author) Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa 2017 In: Psychiatric genetics. - 1473-5873. ; 27:4, s. 152-158 Journal article (peer-reviewed)

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Result 1-10 of 11

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Type of publication: journal article (11)

Type of content: peer-reviewed (11)

Author/Editor: Hebebrand, J. (11)Undo refine; Bulik, CM (8); Ehrlich, S (8); Hakonarson, H (8); Kaprio, J (7); Breen, G (7); show more...; Schmidt, U. (7); Dedoussis, G. (7); Estivill, X (7); Reichborn-Kjennerud, ... (7); Zeggini, E (7); Monteleone, P. (7); Maj, M. (7); Treasure, J (7); Yilmaz, Z (7); Gorwood, P (7); Herzog, W (7); Zipfel, S (7); Keski-Rahkonen, A. (7); Li, D. (6); KLARESKOG, L (6); Roberts, M. (6); Egberts, K. (6); Foretova, L (6); Janout, V (6); Rujescu, D (6); Alfredsson, L (6); Walton, E (6); Cichon, S (6); Le Hellard, S (6); Lissowska, J (6); Ripke, S (6); Lichtenstein, P. (6); Palotie, A (6); Dina, C (6); Esko, T (6); Ripatti, S (6); Jimenez-Murcia, S (6); Fernandez-Aranda, F (6); Widen, E (6); Hauser, J. (6); Herms, S. (6); Tortorella, A. (6); Mattingsdal, M (6); Navratilova, M (6); Ntalla, I (6); Giegling, I (6); Julia, A. (6); Dikeos, D. (6); Marsal, S. (6); show less...

University: Karolinska Institutet (10); University of Gothenburg (3); Örebro University (1)

Language: English (11)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Social Sciences (1)

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