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Träfflista för sökning "WFRF:(Hjerling Leffler J) ;pers:(Ernfors P)"

Search: WFRF:(Hjerling Leffler J) > Ernfors P

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1.	Andang, M, et al. (author) Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation 2008 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 451:7177, s. 460-U4 Journal article (peer-reviewed)
2.	Mohammed, AH, et al. (author) Environmental enrichment and the brain 2002 In: Progress in brain research. - 0079-6123. ; 138, s. 109-133 Journal article (peer-reviewed)
3.	Usoskin, D, et al. (author) Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing 2015 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 18:1, s. 145- Journal article (peer-reviewed)
4.	Zeisel, A, et al. (author) Molecular Architecture of the Mouse Nervous System 2018 In: Cell. - : Elsevier BV. - 1097-4172 .- 0092-8674. ; 174:4, s. 999- Journal article (peer-reviewed)
5.	Agerman, K, et al. (author) BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development 2003 In: Development (Cambridge, England). - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 130:8, s. 1479-1491 Journal article (peer-reviewed)abstract Neurotrophins have multiple functions during peripheral nervous system development such as controlling neuronal survival, target innervation and synaptogenesis. Neurotrophin specificity has been attributed to the selective expression of the Trk tyrosine kinase receptors in different neuronal subpopulations. However, despite overlapping expression of TrkB and TrkC in many sensory ganglia, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) null mutant mice display selective losses in neuronal subpopulations. In the present study we have replaced the coding part of theBDNF gene in mice with that of NT3 (BDNFNT3/NT3)to analyse the specificity and selective roles of BDNF and NT3 during development. Analysis of BDNFNT3/NT3 mice showed striking differences in the ability of NT3 to promote survival, short-range innervation and synaptogenesis in different sensory systems. In the cochlea, specificity is achieved by a tightly controlled spatial and temporal ligand expression. In the vestibular system TrkB or TrkC activation is sufficient to promote vestibular ganglion neuron survival, while TrkB activation is required to promote proper innervation and synaptogenesis. In the gustatory system, NT3 is unable to replace the actions of BDNF possibly because of a temporally selective expression of TrkB in taste neurons. We conclude that there is no general mechanism by which neurotrophin specificity is attained and that specificity is achieved by (i) a tightly controlled spatial and temporal expression of ligands, (ii) different Trk receptors playing distinct roles within the same neuronal subpopulation, or (iii) selective receptor expression in sensory neuron subpopulations.
6.	Hjerling-Leffler, J, et al. (author) Emergence of functional sensory subtypes as defined by transient receptor potential channel expression 2007 In: The Journal of neuroscience : the official journal of the Society for Neuroscience. - 1529-2401. ; 27:10, s. 2435-2443 Journal article (peer-reviewed)
7.	Kobayashi, M, et al. (author) Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc 2006 In: Cell and tissue research. - : Springer Science and Business Media LLC. - 0302-766X .- 1432-0878. ; 323:1, s. 81-90 Journal article (peer-reviewed)
8.	Peng, CG, et al. (author) miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes 2017 In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 356:6343, s. 1168-1171 Journal article (peer-reviewed)abstract A cluster of microRNAs regulates both normal pain sensitivity and the pathological responses of chronic pain.

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (8)

Author/Editor: Ernfors, P (8)Undo refine; Hjerling-Leffler, J (8); Furlan, A (3); Linnarsson, S (2); Abdo, H (2); Usoskin, D (2); show more...; Arenas, E (2); Koltzenburg, M (2); Haring, M (2); Lonnerberg, P (2); Winblad, B (1); Castelo-Branco, G (1); Andang, M (1); Codeluppi, S (1); Li, LL (1); Lallemend, F (1); Eriksson, PS (1); Memic, F (1); Ibanez, CF (1); Lee, K (1); BOGDANOVIC, N (1); Hokfelt, T (1); Agerman, K (1); Blanchard, MP (1); Scarfone, E (1); Canlon, B (1); Nosrat, C (1); Zhang, MD (1); Harkany, T (1); Johnsson, A. (1); Pozas, E (1); Kharchenko, PV (1); Swaab, DF (1); El Manira, A (1); Moliner, A (1); Lundgren, TK (1); Nanou, E (1); Bryja, V (1); Halliez, S (1); Nishimaru, H (1); Wilbertz, J (1); Charnay, P (1); Kobayashi, M. (1); Zhu, SW (1); La Manno, G (1); MOHAMMED, AH (1); Boer, GJ (1); Gonzales, CB (1); Borm, LE (1); Marklund, U (1); show less...

University: Karolinska Institutet (8)

Language: English (8)

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