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Saturated fat is mo...
Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars
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- Luukkonen, Panu K. (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Ali, Ashfaq (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Orho-Melander, Marju (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Lund University, Malmö, Sweden
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- Yki-Järvinen, Hannele (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Sädevirta, Sanja (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Zhou, You (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland; Systems Immunity University Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK
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- Kayser, Brandon (författare)
- Nutriomics Team, Institute of Cardiometabolism and Nutrition, Sorbonne Universités INSERM UMRS 1166, Paris, France
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- Ahonen, Linda (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Lallukka, Susanna (författare)
- Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Pelloux, Véronique (författare)
- Nutriomics Team, Institute of Cardiometabolism and Nutrition, Sorbonne Universités INSERM, UMRS 1166, Paris, France
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- Gaggini, Melania (författare)
- Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy
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- Jian, Ching (författare)
- Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
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- Hakkarainen, Antti (författare)
- Helsinki Medical Imaging Centre, Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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- Lundbom, Nina (författare)
- Helsinki Medical Imaging Centre, Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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- Gylling, Helena (författare)
- Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
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- Salonen, Anne (författare)
- Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Steno Diabetes Center Copenhagen, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Rissanen, Aila (författare)
- Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland
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- Gastaldelli, Amalia (författare)
- Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy
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- Clément, Karine (författare)
- Nutriomics Team, Institute of Cardiometabolism and Nutrition, Sorbonne Universités INSERM, UMRS 1166, Paris, France; Nutrition Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France
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- Hodson, Leanne (författare)
- Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, U.K
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(creator_code:org_t)
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et al
- 2018-05-29
- 2018
- Engelska 8 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 41:8, s. 1732-1739
- Relaterad länk:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG. RESEARCH DESIGN AND METHODS: We overfed 38 overweight subjects (age 48 ± 2 years, BMI 31 ± 1 kg/m2, liver fat 4.7 ± 0.9%) 1,000 extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars (CARB) for 3 weeks. We measured IHTG (1H-MRS), pathways contributing to IHTG (lipolysis ([2H5]glycerol) and DNL (2H2O) basally and during euglycemic hyperinsulinemia), insulin resistance, endotoxemia, plasma ceramides, and adipose tissue gene expression at 0 and 3 weeks. RESULTS: Overfeeding SAT increased IHTG more (+55%) than UNSAT (+15%, P < 0.05). CARB increased IHTG (+33%) by stimulating DNL (+98%). SAT significantly increased while UNSAT decreased lipolysis. SAT induced insulin resistance and endotoxemia and significantly increased multiple plasma ceramides. The diets had distinct effects on adipose tissue gene expression. CONCLUSIONS: Macronutrient composition of excess energy influences pathways of IHTG: CARB increases DNL, while SAT increases and UNSAT decreases lipolysis. SAT induced the greatest increase in IHTG, insulin resistance, and harmful ceramides. Decreased intakes of SAT could be beneficial in reducing IHTG and the associated risk of diabetes. © 2018 by the American Diabetes Association.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ceramide derivative
- saturated fatty acid
- sugar
- triacylglycerol
- unsaturated fatty acid
- edible oil
- fatty acid
- insulin
- monosaccharide
- adipose tissue
- adult
- body weight gain
- carbohydrate metabolism
- clinical article
- Conference Paper
- controlled study
- dietary intake
- endotoxemia
- female
- food composition
- gene expression
- high calorie diet
- human
- hyperinsulinemia
- insulin resistance
- lipid blood level
- lipid metabolism
- lipolysis
- macronutrient
- male
- nonalcoholic fatty liver
- obesity
- proton nuclear magnetic resonance
- blood
- clinical trial
- complication
- feeding behavior
- liver
- metabolism
- middle aged
- physiology
- Adipose Tissue
- Adult
- Carbohydrate Metabolism
- Dietary Fats, Unsaturated
- Fatty Acids
- Feeding Behavior
- Female
- Humans
- Insulin
- Insulin Resistance
- Lipid Metabolism
- Liver
- Male
- Middle Aged
- Monosaccharides
- Non-alcoholic Fatty Liver Disease
- Overweight
- Triglycerides
- Weight Gain
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- Av författaren/redakt...
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Luukkonen, Panu ...
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Ali, Ashfaq
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Orho-Melander, M ...
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Yki-Järvinen, Ha ...
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Sädevirta, Sanja
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Zhou, You
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visa fler...
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Kayser, Brandon
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Ahonen, Linda
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Lallukka, Susann ...
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Pelloux, Véroniq ...
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Gaggini, Melania
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Jian, Ching
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Hakkarainen, Ant ...
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Lundbom, Nina
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Gylling, Helena
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Salonen, Anne
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Oresic, Matej, 1 ...
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Hyötyläinen, Tuu ...
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Rissanen, Aila
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Gastaldelli, Ama ...
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Clément, Karine
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Hodson, Leanne
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Diabetes Care
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