SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Hoffmann Eva R) ;pers:(Metspalu Andres)"

Sökning: WFRF:(Hoffmann Eva R) > Metspalu Andres

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Shungin, Dmitry, et al. (författare)
  • New genetic loci link adipose and insulin biology to body fat distribution.
  • 2015
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 187-378
  • Tidskriftsartikel (refereegranskat)abstract
    • Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
  •  
2.
  • Tsoi, Lam C., et al. (författare)
  • Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
  • 2017
  • Ingår i: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size amp;gt;39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFkB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cells and CD4(+) T-cells including T(H)0, T(H)1 and T(H)17). The identified loci explain similar to 28% of the genetic heritability and generate a discriminatory genetic risk score (AUC = 0.76 in our sample) that is significantly correlated with age at onset (p = 2 x 10(-89)). This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Berne, Christian (1)
Lyssenko, Valeriya (1)
Groop, Leif (1)
Lorentzon, Mattias, ... (1)
März, Winfried (1)
Salomaa, Veikko (1)
visa fler...
Perola, Markus (1)
Chen, Jin (1)
Lind, Lars (1)
Raitakari, Olli T (1)
Kuh, Diana (1)
Haiman, Christopher ... (1)
Berndt, Sonja I (1)
Campbell, Harry (1)
Rudan, Igor (1)
Staessen, Jan A (1)
Ohlsson, Claes, 1965 (1)
Strachan, David P (1)
Deloukas, Panos (1)
Syvänen, Ann-Christi ... (1)
Peters, Ulrike (1)
Johansson, Ingegerd (1)
Shungin, Dmitry (1)
North, Kari E. (1)
Franks, Paul W. (1)
Wareham, Nicholas J. (1)
Hallmans, Göran (1)
Clarke, Robert (1)
Fall, Tove (1)
Stancáková, Alena (1)
Kuusisto, Johanna (1)
Laakso, Markku (1)
McCarthy, Mark I (1)
Ferrannini, Ele (1)
Franco-Cereceda, And ... (1)
Olsson, Christian (1)
Sandholm, Niina (1)
Sennblad, Bengt (1)
Eriksson, Per (1)
Renström, Frida (1)
Ridker, Paul M. (1)
Chasman, Daniel I. (1)
Demirkan, Ayse (1)
Amin, Najaf (1)
van Duijn, Cornelia ... (1)
Rose, Lynda M (1)
Langenberg, Claudia (1)
Magnusson, Patrik K ... (1)
Pedersen, Nancy L (1)
Boehnke, Michael (1)
visa färre...
Lärosäte
Göteborgs universitet (1)
Umeå universitet (1)
Uppsala universitet (1)
Linköpings universitet (1)
Lunds universitet  (1)Ta bort avgränsningen
Karolinska Institutet (1)
visa fler...
Högskolan Dalarna (1)
visa färre...
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy