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Sustained influence...
Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes
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- Preiss, David (författare)
- University of Oxford
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- Dawed, Adem (författare)
- University of Dundee
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- Welsh, Paul (författare)
- University of Glasgow
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- Heggie, Alison (författare)
- University of Newcastle upon Tyne
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- Jones, Angus G. (författare)
- University of Exeter
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- Dekker, Jacqueline (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Koivula, Robert (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Hansen, Tue H. (författare)
- University of Copenhagen
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- Stewart, Caitlin (författare)
- University of Glasgow
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- Holman, Rury R. (författare)
- University of Oxford
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Walker, Mark (författare)
- University of Newcastle upon Tyne
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- Pearson, Ewan R. (författare)
- Ninewells Hospital and Medical School
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- Sattar, Naveed (författare)
- University of Glasgow
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(creator_code:org_t)
- 2016-12-28
- 2017
- Engelska.
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Ingår i: Diabetes, Obesity and Metabolism. - : Wiley. - 1462-8902. ; 19:3, s. 356-363
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Aims: To investigate, in the Carotid Atherosclerosis: Metformin for Insulin Resistance (CAMERA) trial (NCT00723307), whether the influence of metformin on the glucagon-like peptide (GLP)-1 axis in individuals with and without type 2 diabetes (T2DM) is sustained and related to changes in glycaemia or weight, and to investigate basal and post-meal GLP-1 levels in patients with T2DM in the cross-sectional Diabetes Research on Patient Stratification (DIRECT) study. Materials and methods: CAMERA was a double-blind randomized placebo-controlled trial of metformin in 173 participants without diabetes. Using 6-monthly fasted total GLP-1 levels over 18months, we evaluated metformin's effect on total GLP-1 with repeated-measures analysis and analysis of covariance. In the DIRECT study, we examined active and total fasting and 60-minute post-meal GLP-1 levels in 775 people recently diagnosed with T2DM treated with metformin or diet, using Student's t-tests and linear regression. Results: In CAMERA, metformin increased total GLP-1 at 6 (+20.7%, 95% confidence interval [CI] 4.7-39.0), 12 (+26.7%, 95% CI 10.3-45.6) and 18months (+18.7%, 95% CI 3.8-35.7), an overall increase of 23.4% (95% CI 11.2-36.9; P <.0001) vs placebo. Adjustment for changes in glycaemia and adiposity, individually or combined, did not attenuate this effect. In the DIRECT study, metformin was associated with higher fasting active (39.1%, 95% CI 21.3-56.4) and total GLP-1 (14.1%, 95% CI 1.2-25.9) but not post-meal incremental GLP-1. These changes were independent of potential confounders including age, sex, adiposity and glycated haemoglobin. Conclusions: In people without diabetes, metformin increases total GLP-1 in a sustained manner and independently of changes in weight or glycaemia. Metformin-treated patients with T2DM also have higher fasted GLP-1 levels, independently of weight and glycaemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- GLP-1
- Antidiabetic drug
- Metformin
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Preiss, David
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Dawed, Adem
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Welsh, Paul
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Heggie, Alison
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Jones, Angus G.
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Dekker, Jacqueli ...
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visa fler...
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Koivula, Robert
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Hansen, Tue H.
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Stewart, Caitlin
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Holman, Rury R.
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Franks, Paul W.
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Walker, Mark
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Pearson, Ewan R.
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Sattar, Naveed
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