| 1. |
- Bonn, Stephanie E., et al.
(författare)
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Body mass index and weight change in men with prostate cancer : progression and mortality
- 2014
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Ingår i: Cancer Causes and Control. - : Springer Netherlands. - 0957-5243 .- 1573-7225. ; 25:8, s. 933-943
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Tidskriftsartikel (refereegranskat)abstract
- Body mass index (BMI) is a modifiable lifestyle factor that has been associated with an increased risk of fatal prostate cancer and biochemical recurrence. The main purpose of the present study was to investigate the association between the exposure BMI at the time of a prostate cancer diagnosis and weight change after diagnosis, and the outcomes of prostate cancer progression and mortality in a large cohort study. Data from 4,376 men diagnosed with clinically localized prostate cancer between 1997 and 2002 were analyzed. BMI and weight change were self-reported in 2007. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were estimated in complete-case analysis (n = 3,214) using Cox proportional hazards models. Progression was experienced among 639 (14.6 %) of the study participants, and in total, 450 (10.3 %) deaths of any cause and 134 (3.1 %) prostate cancer-specific deaths were recorded during follow-up. Obese men had a 47 % increased rate of overall mortality compared to normal weight men (HR 1.47, 95 % CI 1.03-2.10). No statistically significant associations were found for BMI and prostate cancer progression or prostate cancer-specific mortality. A weight loss > 5 % after diagnosis almost doubled the rate of overall mortality compared to maintaining a stable weight (HR 1.94, 95 % CI 1.41-2.66), while a weight gain > 5 % was associated with an almost doubled increased rate of prostate cancer-specific mortality (HR 1.93, 95 % CI 1.18-3.16). Being obese was associated with an increased rate of overall mortality, and gaining weight after a prostate cancer diagnosis was associated with an increased rate of prostate cancer-specific mortality.
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| 2. |
- Bonn, Stephanie E., et al.
(författare)
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Is leisure time sitting associated with mortality rates among men diagnosed with localized prostate cancer?
- 2020
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Ingår i: European Journal of Cancer Prevention. - : Lippincott Williams & Wilkins. - 0959-8278 .- 1473-5709. ; 29:2, s. 134-140
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Being physically active postdiagnosis has been associated with lower rates of prostate cancer progression and mortality, but studies investigating postdiagnostic time spent sitting are lacking. We aim to study the association between leisure time sitting after a prostate cancer diagnosis and overall and prostate cancer-specific mortality. METHODS: Data from 4595 men in Sweden, diagnosed with localized prostate cancer between 1997-2002 and followed-up until the end of 2012, were analyzed. Time spent sitting during leisure time postdiagnosis was categorized into <2, 2-3, 3-4, and >4 h/day. Multivariable-adjusted Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) of postdiagnosis leisure time sitting and a joint variable of sitting time and exercise, and time to overall or prostate cancer-specific death. RESULTS: The results showed no significant associations between postdiagnostic leisure time sitting and overall or prostate cancer-specific mortality rates. When the joint effect of both sitting and exercise time was considered, borderline significantly lower mortality rates for overall and prostate cancer-specific mortality were seen among participants that sat the least and exercised the most compared to the reference category with participants sitting the most and exercising least (HR: 0.75; 95% CI: 0.56-1.00 and HR: 0.61; 95% CI: 0.36-1.05, respectively). CONCLUSIONS: No significant association between leisure time sitting and mortality rates among men diagnosed with localized prostate cancer was seen. This study does not support an association between leisure time sitting per se; however, being physically active may have beneficial effects on survival among men diagnosed with localized prostate cancer.
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| 3. |
- Bonn, Stephanie E., et al.
(författare)
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Physical Activity and Survival among Men Diagnosed with Prostate Cancer
- 2015
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : AMER ASSOC CANCER RESEARCH. - 1055-9965 .- 1538-7755. ; 24:1, s. 57-64
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Tidskriftsartikel (refereegranskat)abstract
- Background: Few studies have investigated the association between post-diagnosis physical activity and mortality among men diagnosed with prostate cancer. The aim of this study was to investigate the effect of physical activity after a prostate cancer diagnosis on both overall and prostate cancer-specific mortality in a large cohort. Methods: Data from 4,623 men diagnosed with localized prostate cancer 1997-2002 and followed-up until 2012 were analyzed. HRs with 95% confidence intervals (CI) were estimated using Cox proportional hazards models to examine the association between post-diagnosis recreational MET-h/d, time spent walking/bicycling, performing household work or exercising, and time to overall and prostate cancer-specific death. All models were adjusted for potential confounders. Results: During the follow-up, 561 deaths of any cause and 194 deaths from prostate cancer occurred. Statistically significantly lower overall mortality rates were found among men engaged in 5 recreationalMET-h/d (HR, 0.63; 95% CI, 0.52-0.77), walking/ bicycling 20 min/d (HR, 0.70; 95% CI, 0.57-0.86), performing householdwork > 1 h/d (HR, 0.71; 95% CI, 0.59-0.86), or exercising > 1 h/wk (HR, 0.74; 95% CI, 0.61-0.90), compared with less active men within each activity type. For prostate cancer-specific mortality, statistically significantly lower mortality rates were seen among men walking/bicycling >= 20 min/d (HR, 0.61; 95% CI, 0.43-0.87) or exercising 1 h/wk (HR, 0.68; 95% CI, 0.48-0.94). Conclusions: Higher levels of physical activity were associated with reduced rates of overall and prostate cancer-specific mortality. Impact: Our study further strengthens previous results indicating beneficial effects of physical activity on survival among men with prostate cancer. Cancer Epidemiol Biomarkers Prev; 24(1); 57-64.
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| 4. |
- Ghaviha, Nima, et al.
(författare)
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A driver advisory system with dynamic losses for passenger electric multiple units
- 2017
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Ingår i: Transportation Research Part C. - : Elsevier BV. - 0968-090X .- 1879-2359. ; 85, s. 111-130
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Tidskriftsartikel (refereegranskat)abstract
- Driver advisory systems, instructing the driver how to control the train in an energy efficient manner, is one the main tools for minimizing energy consumption in the railway sector. There are many driver advisory systems already available in the market, together with significant literature on the mathematical formulation of the problem. However, much less is published on the development of such mathematical formulations, their implementation in real systems, and on the empirical data from their deployment. Moreover, nearly all the designed driver advisory systems are designed as an additional hardware to be added in drivers’ cabin. This paper discusses the design of a mathematical formulation and optimization approach for such a system, together with its implementation into an Android-based prototype, the results from on-board practical experiments, and experiences from the implementation. The system is based on a more realistic train model where energy calculations take into account dynamic losses in different components of the propulsion system, contrary to previous approaches. The experimental evaluation shows a significant increase in accuracy, as compared to a previous approach. Tests on a double-track section of the Mälaren line in Sweden demonstrates a significant potential for energy saving.
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| 5. |
- Ghaviha, Nima, et al.
(författare)
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Modeling of Losses in the Motor Converter Module of Electric Multiple Units for Dynamic Simulation Purposes
- 2017
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Ingår i: Energy Procedia. - : Elsevier Ltd. - 1876-6102. ; , s. 2303-2309
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Konferensbidrag (refereegranskat)abstract
- Simulation of power consumption in electric trains is categorized in two categories: electrical power simulation and mechanical power simulation. The mechanical power is calculated as speed times tractive effort and it gives an overall view on the total energy consumption of the train during different driving cycles. Detailed calculation of losses in different components in the propulsion system is however done using complex electrical models. In this paper, we introduce a nonlinear regression model generated from validated electrical equations for the calculation of the power loss in the motor converter module of electric trains. The function can be used instead of efficiency maps to evaluate the trains' performance during the operation or dynamic simulations.
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| 6. |
- Ghaviha, Nima, et al.
(författare)
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Speed profile optimization of catenary-free electric trains with lithium-ion batteries
- 2019
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Ingår i: Journal of Modern Transportation. - : Springer Berlin Heidelberg. - 2095-087X .- 2196-0577. ; 27:3, s. 153-168
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Tidskriftsartikel (refereegranskat)abstract
- Catenary-free operated electric trains, as one of the recent technologies in railway transportation, has opened a new field of research: speed profile optimization and energy optimal operation of catenary-free operated electric trains. A well-formulated solution for this problem should consider the characteristics of the energy storage device using validated models and methods. This paper discusses the consideration of the lithium-ion battery behavior in the problem of speed profile optimization of catenary-free operated electric trains. We combine the single mass point train model with an electrical battery model and apply a dynamic programming approach to minimize the charge taken from the battery during the catenary-free operation. The models and the method are validated and evaluated against experimental data gathered from the test runs of an actual battery-driven train tested in Essex, UK. The results show a significant potential in energy saving. Moreover, we show that the optimum speed profiles generated using our approach consume less charge from the battery compared to the previous approaches.
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| 7. |
- Jan, Michael, et al.
(författare)
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The roles of stress and social support in prostate cancer mortality
- 2016
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Ingår i: Scandinavian journal of urology. - : Informa UK Limited. - 2168-1805 .- 2168-1813. ; 50:1, s. 47-55
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study aimed to evaluate the association between perceived stress, social support, disease progression and mortality in a nationwide population-based cohort of men with prostate cancer. Materials and methods: The study surveyed 4105 Swedish men treated for clinically localized prostate cancer regarding stress, grief, sleep habits and social support. Associations between these factors and mortality were assessed using multivariate Cox regression analysis. Results: Men with the highest levels of perceived stress had a statistically significantly increased rate of prostate cancer-specific mortality compared with men with low stress levels (hazard ratio 1.66, 95% confidence interval 1.05-2.63). Men with high stress levels also had a high frequency of grieving and sleep loss. They also had fewer people with whom to share their emotional problems and felt an inability to share most of their problems with partners, friends and family. Conclusions: This study contributes to the growing field of psychosocial quality of life research in men with prostate cancer. The findings show a significant association between prostate cancer-specific mortality and perceived stress in patients initially diagnosed with localized, non-metastatic prostate cancer. Significant associations between perceived stress and various psychosocial factors were also seen. The findings of this study could prove useful to target interventions to improve quality of life in men with prostate cancer.
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