| 1. |
- Moberg, Christina, et al.
(författare)
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De unga gör helt rätt när de stämmer staten
- 2022
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Ingår i: Aftonbladet. - 1103-9000.
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
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| 2. |
- Botling, Johan, et al.
(författare)
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Biomarker Discovery in Non-Small Cell Lung Cancer : Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation
- 2013
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 19:1, s. 194-204
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap.Experimental Design: Here, we describe a novel single institute cohort, including 196 non-small lung cancers (NSCLC) with clinical information and long-term follow-up. Gene expression array data were used as a training set to screen for single genes with prognostic impact. The top 450 probe sets identified using a univariate Cox regression model (significance level P < 0.01) were tested in a meta-analysis including five publicly available independent lung cancer cohorts (n = 860).Results: The meta-analysis revealed 14 genes that were significantly associated with survival (P < 0.001) with a false discovery rate < 1%. The prognostic impact of one of these genes, the cell adhesion molecule 1 (CADM1), was confirmed by use of immunohistochemistry on tissue microarrays from 2 independent NSCLC cohorts, altogether including 617 NSCLC samples. Low CADM1 protein expression was significantly associated with shorter survival, with particular influence in the adenocarcinoma patient subgroup.Conclusions: Using a novel NSCLC cohort together with a meta-analysis validation approach, we have identified a set of single genes with independent prognostic impact. One of these genes, CADM1, was further established as an immunohistochemical marker with a potential application in clinical diagnostics. Clin Cancer Res; 19(1); 194-204. (c) 2012 AACR.
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| 3. |
- Eklöf, Mats, et al.
(författare)
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Workplace intervention for improved risk perception and preventive activity among workers : using hand-held vibrating machines: a pilot study
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This article presents a pilot study of a 1-h workplace educational intervention implemented among ten construction workers who were highly exposed to hand–arm vibration. The intervention combined risk communication and normative expert advice intended to reinforce preventive behaviour related to vibration, noise, and biomechanical loads. Data for this study comprised intervention notes and interview data from interventionists, and pre- and post-intervention interview data from participating workers.The results suggested that the intervention was sensitive to disturbances and should be directed only to motivated workers possessing sufficient self-efficacy, and only in circumstances in which exposure may be controlled on the local workplace level and by locally implemented measures. Unless these conditions are present, the studied intervention may fail to influence preventive behaviour, and may instead cause cognitive dissonance and frustration among participants and interventionists.
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| 4. |
- Holmberg, Mats, Med.Dr. 1976-, et al.
(författare)
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Dyadic teams and nursing care : a critical incident study of nurses in the emergency medical service
- 2020
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Ingår i: Journal of Clinical Nursing. - : John Wiley & Sons. - 0962-1067 .- 1365-2702. ; 29:19-20, s. 3743-3753
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Tidskriftsartikel (refereegranskat)abstract
- Aim and objectives: The aim of the study was to describe Emergency Medical Services (EMS) nurses’ experiences of and coping with critical incidents, when providing nursing care as a member of a dyadic team.Background: Nursing care in EMS is a complex task, taking into account the physical, psychological as well as existential dimensions of the patient's suffering. In this, EMS nurses are dependent on the dyadic team. Teams in EMS are described as essential for providing safe medical care. However, nursing care also comprises relationships with patients as a means of reducing patient suffering.Design: The study has an inductive descriptive qualitative design, in adherence to the COREQ‐checklist.Methods: A critical incident technique was used. Thirty‐five EMS nurses were interviewed individually, with a focus on dyadic teams providing nursing care. The interviews were analysed with the aim of defining main areas, categories and sub‐categories.Results: The experiences of critical incidents emerged to form two main areas: “Functional co‐operation” and “Dysfunctional co‐operation,” comprising seven categories and sixteen sub‐categories. Their coping with critical incidents encompassed two main areas: “Adapting oneself” and “Adapting nursing care and the colleague,” comprising four categories and eight sub‐categories.Conclusions: Reflection as part of the daily practice emerges as important for the development of nursing care both in relation to individual team members and also the dyadic team as a unit. In addition, the results highlight consensus within dyadic teams regarding the objectives of nursing care, as well as the importance of defined roles.Relevance to clinical practice: This study underlines the importance of strengthening the dyadic EMS team's ability to co‐operate using common goals and knowledge within clinical nursing care. The individual team members’ different roles have to be explicit. In addition, clinical care has to be organised to generate preconditions for mutual performance monitoring through collegial feedback and reflection.
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| 5. |
- Holmberg, Rurik, 1967-
(författare)
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Survival of the Unfit : Path Dependence and the Estonian Oil Shale Industry
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Estonia is the only country in the world, which is totally dependent on oil shale in its energy system. Although this fossil fuel exists in enormous quantities around the world, it has so far not been utilized on a larger scale. The reasons for this have been both economic and, in recent times, ecological. It can therefore be argued that in most cases, oil shale represents an inferior solution compared to other energy sources.This work examines why a technology utilizing oil shale has developed in Estonia and why Estonia appears not to be in a position to switch to other energy sources. In this work it is claimed that oil shale actually has been an appropriate solution to short-term concerns, despite the fact that its long-term drawbacks have been identified. These circumstances led to path dependence. Once the technology was in place, it advanced along its learning curve producing a satisfactory outcome, but not an optimal one. However, this situation has been accepted due to the extremely turbulent institutional environment Estonia has undergone in the 20th century.In Sweden, a somewhat similar (but smaller) oil shale industry was shut down in the 1960s because of poor economic performance, but also because of the competition from other energy sources. Such competition did not take place in Estonia, in part due to the specific institutional set-up of the Soviet Union. This made it possible for the Estonian oil shale industry to develop further, causing the present lock-in. Today the existing infrastructure, the knowledge-base, and the particular socio-political circumstances of Estonia effectively prevent change.Furthermore, it is argued that because there was only little oil shale-related technology developed outside Estonia, most technology had to be developed domestically. This in turn has forced the Estonian oil shale industry to make several highly inconvenient alliances in order to gain room to manoeuvre. Partially as a result of this, there is today wide-spread scepticism towards the industry, but no exit in sight in the foreseeable future.One purpose of this work is to contribute to a broader understanding why human societies have become dependent on fossil fuels and to extend our knowledge on where to search for an exit.
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| 6. |
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| 7. |
- Karalexi, Maria, et al.
(författare)
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Cardiovascular outcomes in transgender individuals in Sweden after initiation of gender-affirming hormone therapy
- 2022
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press. - 2047-4873 .- 2047-4881. ; 29:15, s. 2017-2026
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Tidskriftsartikel (refereegranskat)abstract
- Aims We compared the incidence of cardiovascular disease (CVD) in transgender participants with a diagnosis of gender dysphoria (GD) with and without gender-affirming hormone therapy (GAHT) to the incidence observed in the general population. Methods and results The population-based cohort included all individuals >10 years in Sweden linked to Swedish nationwide healthcare Registers (2006-16). Two comparator groups without GD/GAHT were matched (1:10) on age, county of residence, and on male and female birth-assigned sex, respectively. Cox proportional models provided hazard ratios (HRs) and 95% confidence intervals (CI) for CVD outcomes. Among 1779 transgender individuals [48% birth-assigned males (AMAB), 52% birth-assigned females (AFAB)], 18 developed CVD, most of which were conduction disorders. The incidence of CVD for AFAB individuals with GD was 3.7 per 1000 person-years (95% CI: 1.4-10.0). Assigned male at birth individuals with GD had an incidence of CVD event of 7.1 per 1000 person-years (95% CI: 4.2-12.0). The risk of CVD event was 2.4 times higher in AMAB individuals (HR: 2.4, 95% CI: 1.3-4.2) compared with cisgender women, and 1.7 higher compared with cisgender men (HR: 1.7, 95% CI: 1.0-2.9). Analysis limited to transgender individuals without GAHT yielded similar results to those with GAHT treatment. Conclusion The incidence of CVD among GD/GAHT individuals was low, although increased compared with matched individuals without GD and similar to the incidence among GD/no GAHT individuals, thus not lending support for a causal relationship between treatment and CVD outcomes. Larger studies with longer follow-up are needed to verify these findings, as well as possible effect modification by comorbidity.
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| 8. |
- Khamisi, Selwan, et al.
(författare)
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Fracture Incidence in Graves' Disease: A Population-Based Study.
- 2023
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Ingår i: Thyroid : official journal of the American Thyroid Association. - : Mary Ann Liebert. - 1557-9077 .- 1050-7256. ; 33:11, s. 1349-1357
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Tidskriftsartikel (refereegranskat)abstract
- Background: Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The aim of this study was to investigate fracture risk in patients with GD. Methods: A total of 2134 patients with incident GD and 21,261 age, sex- and county-matched controls were included 16-18 years after diagnosis in a retrospective cohort study. Drug and patient national registries in Sweden were used to assess the risk of developing skeletal complications. Up to 10 years of age, sex- and county-matched controls per patient were selected from databases from the National Board of Health and Welfare and Statistics Sweden. Cox proportional hazards models were fitted to estimate hazard ratios (HR) and confidence intervals [CI]. Results: There were no significant differences in fracture rates between GD and controls but after adjustment for comorbidities, the data showed higher vertebral fracture rates in male GD patients aged >52 years compared to male controls, HR=2.83 [CI 1.05-7.64]. The rates of osteoporosis treatments as well as treatment with corticosteroids were higher in patients with GD. However, HR for the association between GD and fractures remained largely unchanged after adjustment for osteoporosis treatments and treatments with corticosteroids. Conclusions: There were no significant differences in total fracture rate between GD and the general population. However, men older than 52 years had a higher vertebral fracture rate. This study also shows that patients with treated GD receive more osteoporosis treatments compared to the general population.
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| 9. |
- Levine, Hagai, et al.
(författare)
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Male reproductive health statement (XIIIth international symposium on Spermatology, may 9th-12th 2018, Stockholm, Sweden
- 2018
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Ingår i: Basic and Clinical Andrology. - : Springer Science and Business Media LLC. - 2051-4190. ; 28:1
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Tidskriftsartikel (refereegranskat)abstract
- On the occasion of the XIIIth International Symposium on Spermatology held from 9 to 13 May 2018 in Stockholm (Sweden), participants (guest speakers and audience) collectively felt the need to make a public statement on the general issue of male reproductive health. Our intention is to raise awareness of what we believe is a neglected area of research despite alarming situations around the world. The disclosure strategy desired by the co-authors is to bring it to the attention of the greatest number partly by considering co-publication in the various periodicals dealing with Reproductive Biology and Andrology. BaCA's editorial office accepted this mission and found it natural that our periodical, the official journal of the French Andrology Society (SALF), should carry this message.
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| 10. |
- Tinnsten, Mats, et al.
(författare)
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Projekt Davos : hjälper längdlandslaget att åka fortare
- 2004
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Ingår i: Svensk Idrottsforskning. - Sth. : Centrum för idrottsforskning. - 1103-4629. ; 13:1, s. 25-27
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Tidskriftsartikel (refereegranskat)abstract
- DAVOS – Datorbaserade verktyg för optimering och simulering är ett EU fi nansierat (Mål 1) projekt som handlar om tillämpad teknik och tilllämpad optimering. Projektet omfattar ca 10 personer, ca 20 miljoner kr och kommer att pågå fram till 2004. Projektet drivs av institutionen för informationsteknologi och medier vid Mitthögskolan i Östersund men även personal från institutionen för teknik, fysik och matematik ingår och projektledare är docent Mats Tinnsten. I projektet ingår sex delprojekt varav två har en inriktning mot sport och sportrel aterad utrustning. DAVOS har goda kontakter med den regionala industrin, internationella universitet och forskargrupper, nationella universitet, forskargrupper och projekt. Särskilt goda och givande kontakter har projektet med Nationellt Vintersportcentrum och längdskidlandslaget samt ett antal elitskidåkare som har varit eller är studenter vid någon av teknikinstitutionerna vid campus Östersund. DAVOS handlar alltså om tillämpad teknik och optimering och verksamheten är inriktad på numeriska simuleringar och analyser av tekniska tillämpningar vilket närmast faller inom området maskinteknik och man kan ju fråga sig hur detta kan kopplas till området sport och sportutrustning. På ett alldeles naturligt sätt anser deltagarna i projektet och förhoppningsvis ska detta klarna vid genomläsning av den resterande texten.
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