SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Holmberg Per 1964) "

Sökning: WFRF:(Holmberg Per 1964)

  • Resultat 1-10 av 80
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Leidermark, Erik, 1981, et al. (författare)
  • Estimating the risk for secondary cancer following targeted alpha therapy with astatine-211 intraperitoneal radioimmunotherapy.
  • 2022
  • Ingår i: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - : Society of Nuclear Medicine. - 1535-5667. ; 64:1, s. 165-172
  • Tidskriftsartikel (refereegranskat)abstract
    • Intraperitoneal 211At-based targeted alpha therapy (TAT) may hold most promise as an adjuvant therapy following surgery and chemotherapy in epithelial ovarian cancer to eradicate any remaining undetectable disease. This implies it will also be delivered to patients possibly already cured by the primary treatment. An estimate of long-term risks is therefore sought whether to justify the treatment. Methods: Baseline data for risk estimates of alpha-particle irradiation were collected from published studies on excess cancer induction and mortality for subjects exposed to either 224Ra treatments or Thorotrast contrast agent (25% ThO2 colloid, containing 232Th). Organ dosimetry for 224Ra and Thorotrast irradiation were taken from the literature. These organ-specific risks were then applied for our previously reported dosimetry for intraperitoneal (i.p.) 211At-TAT patients. Results: Risk could be estimated for 10 different organ or organ groups. The calculated excess relative risk per Gray (ERR/Gy) could be sorted into two groups. In the lower ERR/Gy group, up to approx. 5, were: Trachea, bronchus and lung 0.52 (CI 95% 0.21-0.82), Stomach 1.4 (CI 95% -5.0-7.9), Lymphoid and hematopoietic system 2.17 (CI 95% 1.7-2.7), Bone and articular cartilage 2.6 (CI 95% 2.0-3.3), Breast 3.45 (CI 95% -10-17) and Colon 4.5 (CI 95% -3.5-13). In the higher ERR/Gy group, ranging from approx. 10 to 15 were: Urinary bladder 10.1 (CI 95% 1.4-23), Liver 14.2 (CI 95% 13-16), Kidney 14.9 (CI 95% 3.9-26) and Lip, oral cavity and pharynx 15.20 (CI 95% 2.73-27.63). Applying a typical candidate patient (female, age 65 years) and correcting for reference population mortality rate, a total estimated excess mortality of an i.p. 211At-mAb treatment amounted to 1.13 per 100 treated. More than half of this excess originated from urinary bladder and kidney, 0.29 and 0.34 respectively. Depending on various adjustments in calculation and assumptions on competing risks excess mortality could range from 0.11 - 1.84 per 100 treated. Conclusion: Published epidemiological data on life-long detriment following alpha-particle irradiation and its dosimetry allowed calculations to estimate the risk for secondary cancer following 211At-based i.p. TAT. Measures to reduce dose to the urinary organs may further decrease the estimated relative low risk for secondary cancer from 211At-mAb based i.p. TAT.
  •  
2.
  • Chamalidou, Chaido, 1972, et al. (författare)
  • Survival patterns of invasive lobular and invasive ductal breast cancer in a large population-based cohort with two decades of follow up
  • 2021
  • Ingår i: Breast. - : Churchill Livingstone. - 0960-9776 .- 1532-3080. ; 59, s. 294-300
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Invasive lobular carcinoma (ILC) comprises 8-15 % of all invasive breast cancers and large population-based studies with >10 years of follow-up are rare. Whether ILC has a long-time prognosis different from that of invasive ductal carcinoma, (IDC) remains controversial. Purpose: To investigate the excess mortality rate ratio (EMRR) of patients with ILC and IDC and to correlate survival with clinical parameters in a large population-based cohort. Material and methods: From 1989 through 2006, we identified 17,481 patients diagnosed with IDC (n = 14,583) or ILC (n = 2898), younger than 76 years from two Swedish Regional Cancer Registries. Relative survival (RS) during 20 years of follow up was analysed. Results: ILC was significantly associated with older age, larger tumours, ER positivity and well differentiated tumours. We noticed an improved survival for patients with ILC during the first five years, excess mortality rate ratio (EMRR) 0.64 (CI 95 % 0.53-0.77). This was shifted to a significant decreased survival 10-15 years after diagnosis (EMRR 1.49, CI 95 % 1.16-1.93). After 20 years the relative survival rates were similar, 0.72 for ILC and 0.73 for IDC. Conclusions: During the first five years after surgery, the EMRR was lower for patients with ILC as compared to patients with IDC, but during the years 10-15 after surgery, we observed an increased EMRR for patients with ILC as compared to IDC. These EMRR between ILC and IDC were statistically significant but the absolute difference in excess mortality between the two groups was small. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  •  
3.
  • Den gåtfulla Rökstenen
  • 2022
  • Konstnärligt arbeteabstract
    • Utställningen Den gåtfulla Rökstenen bjöd på en mystisk resa tillbaka till det vikingatida Rök, på den östgötska slätten, där Rökstenen restes någon gång på 800-talet e.Kr. Med sina 760 tecken har Rökstenen världens längsta runinskrift. Runorna är förhållandevis lätta att läsa, men desto svårare att tolka.Den traditionella tolkningen av Rökstenens inskrift har varit att den handlar om kejsaren Theoderik den store, som runt år 500 härskade i Italien. Men varför skulle en runsten i Östergötland tala om honom?  Det som ristats på Rökstenen bör i stället hänga ihop med den plats där stenen är rest, menar språkforskaren Per Holmberg. Efter flera år av forskning har han presenterat en omtolkning av Rökstenens inskrift: den handlar om kampen mellan ljus och mörker.  
  •  
4.
  • Holmberg, Per, 1964, et al. (författare)
  • Systemisk-funktionell lingvistik. Att analysera språkets betydelsepotential
  • 2014
  • Ingår i: Folkmålsstudier. - 0356-1771. ; 52, s. 9-30
  • Tidskriftsartikel (refereegranskat)abstract
    • This article presents the theory of Systemic functional linguistics (SFL), first developed by Michael Halliday, and exemplifies how the theory can be applied in empirical analysis of text and talk. It shows how SFL is centered on the idea that language functions in social meaning making, and how this idea is theoretically elaborated in terms of stratification, metafunctional diversity, systemic choices and registers. The article includes a theoretical description of these four central notions, followed by a presentation of two empirical studies. Both studies explore lexicogrammatical and semantic choices within the ideational metafunction, though in different registers. The first study is an analysis of the use of grammatical metaphor in text written by monolingual and multilingual upper secondary school students. Grammatical metaphor is the realization of meaning in atypical, or incongruent, ways. In the study, grammatical metaphor is a developmental trait, allowing students to express specialized meanings through new combinations between semantics and lexicogrammar. In the second analysis SFL is applied on talk in interaction and combined with activity analysis. The study explores the successive instantiation of the meaning potential of language in a certain context, namely when participants talk about thinking in radio phone-in counseling conversations. An analysis within the ideational metafunction combined with the notion of communicative projects describes how, in this specific case, the participants’ lexicogrammatical choices between a verb and a nominal form contributes in a critical way to a successful outcome of the ongoing counseling activity.
  •  
5.
  •  
6.
  • Nordenskjöld, Anna, 1969, et al. (författare)
  • Breast cancer survival trends in different stages and age groups - a population-based study 1989-2013
  • 2019
  • Ingår i: Acta Oncologica. - : TAYLOR & FRANCIS LTD. - 0284-186X .- 1651-226X. ; 58:1, s. 45-51
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: During the recent decades, breast cancer survival has gradually improved but there is limited knowledge on the improvement in population-based studies of patients diagnosed with different stages of the disease and in different age groups.Patients and methods: In two Swedish health care regions a total of 42,220 female breast cancer patients below 90years of age were diagnosed between 1989 and 2013. They were treated and followed according to national and regional guidelines and formed a population-based cohort.Results: Using patients diagnosed in 1989-1993 as a reference to the relative risk, 5-year mortality decreased with 49% for patients diagnosed at the end of the observation period (CI 95% 45-58). The mortality tended to decrease for patients with all stages of breast cancer and test for trend resulted in a statistically significant improvement over time in 5-year relative survival in stage III and IV and in 10-year survival in stage I and III. For each operable stage of disease, patients aged below 40years or more than 70years when diagnosed tended to have less favorable survival than patients diagnosed between 40-69years of age. Test for trend resulted in statistically significant improvements over time for patients diagnosed at ages below 40, 40-54 and 54-69, but less marked improvements for patients older than 70 when diagnosed.Conclusions: During the period 1989-2013 the relative risk of 5-year mortality decreased with 49%. Improvements were seen in all age groups but were unevenly distributed between stages and age groups pointing to the need for further improvements for younger and elderly patients.
  •  
7.
  • Nordenskjöld, Anna, 1969, et al. (författare)
  • No clear effect of postoperative radiotherapy on survival of breast cancer patients with one to three positive nodes: a population-based study
  • 2015
  • Ingår i: Annals of Oncology. - : Oxford University Press (OUP): Policy B - Oxford Open Option F. - 0923-7534 .- 1569-8041. ; 26:6, s. 1149-1154
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: In published radiotherapy trials, the failure rate in the control arm among patients with one to three positive nodes is high compared with that seen with modern adjuvant treatments. Therefore, the generalizability of the results has been questioned. The aim of the present study was to compare relative survival in breast cancer patients between two Swedish regions with screening mammography programs and adjuvant treatment guidelines similar with the exception of the indication of radiotherapy for patients with one to three positive nodes. Patients and methods: Between 1989 and 2006, breast cancer patients were managed very similarly in the west and southeast regions, except for indication for postoperative radiotherapy. In patients with one to three positive nodes, post-mastectomy radiotherapy was generally given in the southeast region (89% of all cases) and generally not given in the west region (15% of all cases). For patients with one to three positive nodes who underwent breast-conserving surgery, patients in the west region had breast radiotherapy only, while patients in the southeast region had both breast and lymph nodes irradiated. Results: The 10-year relative survival for patients with one to three positive lymph nodes was 78% in the west region and 77% in the southeast region (P = 0.12). Separate analyses depending on type of surgery, as well as number of examined nodes, also revealed similar relative survival. Conclusion: Locoregional postoperative radiotherapy has well-known side-effects, but in this population-based study, there was little or no influence of this type of radiotherapy on survival when one to three lymph nodes were involved.
  •  
8.
  • Andersson, Peter, 1974, et al. (författare)
  • Inledning
  • 2014
  • Ingår i: Mångfaldens möjligheter. Litteratur- och språkdidaktik i Norden, red. Andersson, Holmberg, Lyngfelt, Nordenstam, Widhe. - Göteborg : Nätverket för svenska med didaktisk inriktning (SMDI).
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
  •  
9.
  • Apelgren, Britt Marie, 1956, et al. (författare)
  • Constructing and Construing Written Argumentative and Expository Assignments in L1 and EFL
  • 2014
  • Ingår i: AILA World Congress 10-15 August 2014 Brisbane Australia.
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
    • This paper presents part of a longitudinal research project investigating 200 Swedish upper secondary students' written academic language in Swedish and English during a period of three years. Eight different writing assignments, designed to correspond with the national curricula for social and natural science, are analysed as choices of genres and text outlines in 1600 student essays.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 80
Typ av publikation
tidskriftsartikel (35)
bokkapitel (18)
konferensbidrag (11)
rapport (5)
samlingsverk (redaktörskap) (2)
bok (2)
visa fler...
annan publikation (2)
doktorsavhandling (2)
konstnärligt arbete (1)
proceedings (redaktörskap) (1)
recension (1)
visa färre...
Typ av innehåll
refereegranskat (41)
övrigt vetenskapligt/konstnärligt (37)
populärvet., debatt m.m. (1)
Författare/redaktör
Holmberg, Erik, 1951 (12)
Dahm-Kähler, Pernill ... (8)
Stålberg, Karin (8)
Bjurberg, Maria (6)
Albertsson, Per, 196 ... (5)
Karlsson, Per, 1963 (4)
visa fler...
Hellman, K (4)
Åvall-Lundqvist, Eli ... (4)
Holm, Ann-Sofie, 195 ... (3)
Lyngfelt, Anna, 1965 (3)
Andersson, Peter, 19 ... (2)
Holmberg, Erik (2)
Hellman, Kristina (2)
Staf, C. (2)
Falconer, H. (2)
Wirdenäs, Karolina, ... (2)
Karlsson, Anna-Malin ... (2)
Williams, Henrik, 19 ... (1)
Linderholm, Barbro, ... (1)
Kumlien, Eva (1)
Andersson, Per-Ola, ... (1)
Castedal, Maria, 196 ... (1)
Brandberg, Yvonne (1)
Påhlman, Magnus, 196 ... (1)
Nilsson, Sten (1)
Raininko, Raili, 194 ... (1)
Nordenskjöld, Bo, 19 ... (1)
Jacobsson, Lars (1)
Holmberg, E. (1)
Damber, Jan-Erik, 19 ... (1)
Nord, Andreas (1)
Hellström, Per (1)
Brune, Mats, 1950 (1)
Isacsson, Ulf (1)
Nordenskjöld, Bo (1)
Eriksson, Urban (1)
Jonsson, Per R., 195 ... (1)
Ledin, Per (1)
Dahl, Niklas (1)
Bäck, Tom, 1964 (1)
Johansson, Mia, 1977 (1)
Lindegren, Sture, 19 ... (1)
Palm, Stig, 1964 (1)
Lennernäs, Bo, 1963 (1)
Veskovski, Ljupco (1)
Lausmaa, Jukka (1)
Ängsal, Magnus Pette ... (1)
Darin, Niklas, 1964 (1)
Elwing, Hans-Björne, ... (1)
Holmberg, Krister, 1 ... (1)
visa färre...
Lärosäte
Göteborgs universitet (72)
Uppsala universitet (9)
Linköpings universitet (6)
Stockholms universitet (4)
Lunds universitet (4)
Luleå tekniska universitet (3)
visa fler...
Södertörns högskola (2)
Karolinska Institutet (2)
Kungliga Tekniska Högskolan (1)
Jönköping University (1)
Chalmers tekniska högskola (1)
Högskolan i Borås (1)
visa färre...
Språk
Svenska (45)
Engelska (35)
Forskningsämne (UKÄ/SCB)
Humaniora (53)
Samhällsvetenskap (26)
Medicin och hälsovetenskap (17)
Naturvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy