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Treatment Satisfact...
Treatment Satisfaction and Well-Being With CGM in People With T1D: An Analysis Based on the GOLD Randomized Trial
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- Pylov, Daniel (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Polonsky, W. (författare)
- University of California,Behavioral Diabetes Institute, San Diego, CA, USA;University of California, San Diego, CA, USA,Behav Diabet Inst, CA USA; Univ Calif San Diego, CA USA
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- Imberg, Henrik, 1991 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg,Chalmers University of Technology, Gothenburg, Sweden;University of Gothenburg, Gothenburg, Sweden;Statistiska Konsultgruppen, Gothenburg, Sweden,Chalmers Univ Technol, Sweden; Univ Gothenburg, Sweden; Statist Konsultgruppen, Sweden
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- Holmer, H. (författare)
- Centralsjukhuset Kristianstad,Kristianstad Central Hospital,Department of Internal Medicine, Centralsjukhuset, Kristianstad, Sweden
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- Hellman, Jarl (författare)
- Uppsala universitet,Klinisk diabetologi och metabolism,Uppsala Univ, Sweden
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- Wijkman, Magnus (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Medicinkliniken ViN
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- Bolinder, J. (författare)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
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- Heisse, T. (författare)
- Profil Institut für Stoffwechselforschung GmbH,Profil,Profil, Neuss, Germany
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- Dahlqvist, S. (författare)
- NU-sjukvården,NU Hospital Group,Department of Medicine, NU Hospital Group, Uddevalla, Sweden,NU Hosp Grp, Sweden
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- Nystrom, T. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Schwarz, E. (författare)
- Department of Internal Medicine, Faculty of Medicine & Health, Örebro University, Örebro Sweden,Orebro Univ, Sweden
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- Hirsch, I. (författare)
- School of Medicine, University of Washington, Seattle, WA, USA,Univ Washington, WA USA
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- Lind, Marcus, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,NU-sjukvården,NU Hospital Group,University of Gothenburg,Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden;Department of Medicine, NU Hospital Group, Uddevalla, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden; NU Hosp Grp, Sweden; Univ Gothenburg, Sweden
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(creator_code:org_t)
- Sage Publications, 2023
- 2023
- Engelska.
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Ingår i: Journal of Diabetes Science and Technology. - : Sage Publications. - 1932-2968.
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Abstract
Ämnesord
Stäng
- Background: The GOLD trial demonstrated that continuous glucose monitoring (CGM) in people with type 1 diabetes (T1D) managed with multiple daily insulin injections (MDI) improved not only glucose control but also overall well-being and treatment satisfaction. This analysis investigated which factors contributed to improved well-being and treatment satisfaction with CGM. Methods: The GOLD trial was a randomized crossover trial comparing CGM versus self-monitored blood glucose (SMBG) over 16 months. Endpoints included well-being measured by the World Health Organization-Five Well-Being Index (WHO-5) and treatment satisfaction by the Diabetes Treatment Satisfaction Questionnaire (DTSQ) as well as glucose metrics. Multivariable R-2-decomposition was used to understand which variables contributed most to treatment satisfaction. Results: A total of 139 participants were included. Multivariable analyses revealed that increased convenience and flexibility contributed to 60% (95% confidence interval [CI] = 50%-69%) of the improvement in treatment satisfaction (Diabetes Treatment Satisfaction Questionnaire change version [DTSQc]) observed with CGM, whereas perceived effects on hypoglycemia and hyperglycemia only contributed to 6% (95% CI = 2%-11%) of improvements. Significant improvements in well-being (WHO-5) by CGM were observed for the following: feeling cheerful (P = .025), calm and relaxed (P = .024), being active (P = .046), and waking up fresh and rested (P = .044). HbA1c reductions and increased time in range (TIR) were associated with increased treatment satisfaction, whereas glycemic variability was not. HbA1c reduction showed also an association with increased well-being and increased TIR with less diabetes-related distress. Conclusions: While CGM improves glucose control in people with T1D on MDI, increased convenience and flexibility through CGM is of even greater importance for treatment satisfaction and patient well-being. These CGM-mediated effects should be taken into account when considering CGM initiation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- CGMS
- MDI
- quality of life
- SMBG
- treatment satisfaction
- type 1
- diabetes
- quality-of-life
- problem-areas
- type-1
- depression
- countries
- insulin
- adults
- impact
- Endocrinology & Metabolism
- SMBG
- Medicinsk vetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pylov, Daniel
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Polonsky, W.
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Imberg, Henrik, ...
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Holmer, H.
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Hellman, Jarl
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Wijkman, Magnus
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visa fler...
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Bolinder, J.
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Heisse, T.
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Dahlqvist, S.
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Nystrom, T.
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Schwarz, E.
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Hirsch, I.
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Lind, Marcus, 19 ...
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Göteborgs universitet
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