| 1. |
- Bjermer, Leif, et al.
(författare)
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The complex pathophysiology of allergic rhinitis : Scientific rationale for the development of an alternative treatment option
- 2019
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Ingår i: Allergy, Asthma and Clinical Immunology. - : Springer Science and Business Media LLC. - 1710-1492. ; 15, s. 24-
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Forskningsöversikt (refereegranskat)abstract
- Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes. We focus on the benefits and drawbacks of different treatment options and delivery routes for AR treatments and consider how, given what is known about AR pathophysiology and symptomatology, patients may be offered more effective treatment options for rapid, effective, and sustained AR control. In particular, we consider how a new AR preparation, MP-AzeFlu (Dymista ® , Meda, Sweden), comprising a formulation of an intranasal antihistamine (azelastine hydrochloride), an intranasal corticosteroid (fluticasone propionate), and excipients delivered in a single spray, may offer benefits over and above single and multiple AR therapy options. We review the evidence in support of this treatment across the spectrum of AR disease. The concept of AR control is also reviewed within the context of new European Union and Contre les Maladies Chroniques pour un VIeillissement Actif-Allergic Rhinitis and its Impact on Asthma initiatives.
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| 2. |
- Felton, Adam, et al.
(författare)
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The tree species matters : Biodiversity and ecosystem service implications of replacing Scots pine production stands with Norway spruce.
- 2020
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Ingår i: Ambio. - : Springer. - 0044-7447 .- 1654-7209. ; 49:5, s. 1035-1049
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Forskningsöversikt (refereegranskat)abstract
- The choice of tree species used in production forests matters for biodiversity and ecosystem services. In Sweden, damage to young production forests by large browsing herbivores is helping to drive a development where sites traditionally regenerated with Scots pine (Pinus sylvestris) are instead being regenerated with Norway spruce (Picea abies). We provide a condensed synthesis of the available evidence regarding the likely resultant implications for forest biodiversity and ecosystem services from this change in tree species. Apart from some benefits (e.g. reduced stand-level browsing damage), we identified a range of negative outcomes for biodiversity, production, esthetic and recreational values, as well as increased stand vulnerability to storm, frost, and drought damage, and potentially higher risks of pest and pathogen outbreak. Our results are directly relevant to forest owners and policy-makers seeking information regarding the uncertainties, risks, and trade-offs likely to result from changing the tree species in production forests.
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| 3. |
- Holmström, Mats, et al.
(författare)
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Allergisk rinit hos barn och vuxna : Råd vid behandling anpassade till svenska förhållanden med avstamp i de senaste internationella riktlinjerna [Allergic rhinitis in children and adults - international recommendations adapted to the clinical situation in Sweden]
- 2023
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Ingår i: Läkartidningen. - : Sveriges Läkarförbund. - 0023-7205 .- 1652-7518. ; 120
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Forskningsöversikt (refereegranskat)abstract
- Allergic rhinitis is the most common chronic disease in Sweden, with impact on quality of life and with a heavy economic burden for the society. More than 20 years have passed since national recommendations were launched, and meanwhile both ARIA (Allergic rhinitis and its impact of asthma) and EUFOREA (The European Forum for Research and Education in Allergy and Airway Diseases) have presented international guidelines which in this article have been adapted to the clinical situation in Sweden. Visual analogue scale (VAS) is recommended for symptom evaluation, and the importance of correct allergen analysis and examination for coexisting asthma is emphasized. Treatment is recommended according to EUFOREA. Follow-up is important, and if VAS is =5 the disease is regarded as uncontrolled and must lead to a change of treatment. Since self-treatment is common in allergic rhinitis the importance of patient cooperation and information is underlined.
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| 4. |
- Holmström, Mats, et al.
(författare)
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Future opportunities in solar system plasma science through ESA's exploration programme
- 2024
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Ingår i: npj Microgravity. - : Springer Nature. - 2373-8065. ; 10:1
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Forskningsöversikt (refereegranskat)abstract
- The solar wind interacts with all solar system bodies, inducing different types of dynamics depending on their atmospheric and magnetic environments. We here outline some key open scientific questions related to this interaction, with a focus on the Moon and Mars, that may be addressed by future Mars and Moon missions by the European Space Agency's Human and Robotic Exploration programme. We describe possible studies of plasma interactions with bodies with and without an atmosphere, using multi-point and remote measurements, and energetic particle observations, as well as recommend some actions to take.
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| 5. |
- Holmström, Mats
(författare)
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The use of objective measures in selecting patients for septal surgery
- 2010
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Ingår i: Rhinology. - 0300-0729 .- 1996-8604. ; 48:4, s. 387-393
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Forskningsöversikt (refereegranskat)abstract
- To improve results in septal surgery, patient selection is the mainstay of a successful outcome. Patient history is the basis as well as clinical examination but both are subjective and must be considered towards a background with a high frequency of septal deviation in the population and a lack of good correlation between function and status. Rhinomanometry and acoustic rhinometry as well as nasal peak inspiratory flow are tests of different nasal parameters as resistance to breathing, nasal dimensions and flow. This article illuminates the use of these more objective tests in selection of patients for septoplasty. Objective tests have in several studies shown to predict postoperative satisfaction while normal values can be a marker for a poor surgical outcome. Pros and cons with objective tests are discussed and the conclusion is: operate when there is a good correlation between the patient's status, history and the results of rhinometry!
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