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Neurodevelopmental ...
Neurodevelopmental outcome in extremely preterm infants at 2.5 years after active perinatal care in Sweden.
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- Serenius, Fredrik, 1939- (författare)
- Umeå universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Hellström-Westas,Pediatrik,Department of Women's and Children's Health, Section for Pediatrics, Uppsala University, Uppsala, Sweden,Uppsala University, Sweden Umeå University, Sweden
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- Källén, Karin (författare)
- Lund University,Lunds universitet,Tornbladinstitutet,Forskargrupper vid Lunds universitet,Tornblad Institute,Lund University Research Groups,Centre of Reproductive Epidemiology, Lund University, Lund, Sweden
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- Blennow, Mats (författare)
- Karolinska Institutet
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- Ewald, Uwe, 1945- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson,Department of Women's and Children's Health, Section for Pediatrics, Uppsala University, Uppsala, Sweden
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- Fellman, Vineta (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden
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- Holmström, Gerd (författare)
- Uppsala universitet,Oftalmiatrik,Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden
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- Lindberg, Eva (författare)
- Department of Pediatrics, Örebro University, Örebro, Sweden
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- Lundqvist, Pia (författare)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups,Departments of Pediatrics, Health Sciences, Lund University, Sweden
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- Marsal, Karel (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Obstetrics and Gynecology, Clinical Sciences Lund, Lund University, Lund, Sweden
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- Norman, Mikael (författare)
- Karolinska Institutet
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- Olhager, Elisabeth (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Stigson, Lennart (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Sweden
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- Stjernqvist, Karin (författare)
- Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences,Department of Psychology, Lund University, Lund, Sweden
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- Vollmer, Brigitte (författare)
- Karolinska Institutet
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- Strömberg, Bo, 1944- (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnneurologisk forskning/Ahlsten,Department of Women's and Children's Health, Section for Pediatrics, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- American Medical Association (AMA), 2013
- 2013
- Engelska.
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Ingår i: Journal of the American Medical Association. - : American Medical Association (AMA). - 0098-7484 .- 1538-3598. ; 309:17, s. 1810-20
- Relaterad länk:
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https://jamanetwork....
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Importance Active perinatal care increases survival of extremely preterm infants; however, improved survival might be associated with increased disability among survivors. Objective To determine neurodevelopmental outcome in extremely preterm children at 2.5 years (corrected age). Design, Setting, and Participants Population-based prospective cohort of consecutive extremely preterm infants born before 27 weeks of gestation in Sweden between 2004 and 2007. Of 707 live-born infants, 491 (69%) survived to 2.5 years. Survivors were assessed and compared with singleton control infants who were born at term and matched by sex, ethnicity, and municipality. Assessments ended in February 2010 and comparison estimates were adjusted for demographic differences. Main Outcomes and Measures Cognitive, language, and motor development was assessed with Bayley Scales of Infant and Toddler Development (3rd edition; Bayley-III), which are standardized to mean (SD) scores of 100 (15). Clinical examination and parental questionnaires were used for diagnosis of cerebral palsy and visual and hearing impairments. Assessments were made by week of gestational age. Results At a median age of 30.5 months (corrected), 456 of 491 (94%) extremely preterm children were evaluated (41 by chart review only). For controls, 701 had information on health status and 366 had Bayley-III assessments. Mean (SD) composite Bayley-III scores (cognition, 94 [12.3]; language, 98 [16.5]; motor, 94 [15.9]) were lower than the corresponding mean scores for controls (cognition, 104 [10.6]; P < .001; adjusted difference in mean scores, 9.2 [99% CI, 6.9-11.5]; language, 109 [12.3]; P < .001; adjusted difference in mean scores, 9.3 [99% Cl, 6.4-12.3]; and motor, 107 [13.7]; P < .001; adjusted difference in mean scores, 12.6 [99% Cl, 9.5-15.6]). Cognitive disability was moderate in 5% of the extremely preterm group vs 0.3% in controls (P < .001) and it was severe in 6.3% of the extremely preterm group vs 0.3% in controls (P < .001). Language disability was moderate in 9.4% of the extremely preterm group vs 2.5% in controls (P < .001) and severe in 6.6% of the extremely preterm group vs 0% in controls (P < .001). Other comparisons between the extremely preterm group vs controls were for cerebral palsy (7.0% vs 0.1%; P < .001), for blindness (0.9% vs 0%; P = .02), and for hearing impairment (moderate and severe, 0.9% vs 0%; P = .02, respectively). Overall, 42% (99% CI, 36%-48%) of extremely preterm children had no disability, 31% (99% CI, 25%-36%) had mild disability, 16% (99% CI, 12%-21%) had moderate disability, and 11% (99% CI, 7.2%-15%) had severe disability. Moderate or severe overall disability decreased with gestational age at birth (22 weeks, 60%; 23 weeks, 51%; 24 weeks, 34%; 25 weeks, 27%; and 26 weeks, 17%; P for trend < .001). Conclusions and Relevance Of children born extremely preterm and receiving active perinatal care, 73% had mild or no disability and neurodevelopmental outcome improved with each week of gestational age. These results are relevant for clinicians counseling families facing extremely preterm birth. JAMA. 2013;309(17):1810-1820
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Blindness
- Case-Control Studies
- Cerebral Palsy
- Child Development
- Child
- Preschool
- Cognition
- Developmental Disabilities
- Disabled Children
- statistics & numerical data
- Female
- Gestational Age
- Humans
- Infant
- Infant
- Extremely Premature
- physiology
- psychology
- Infant
- Newborn
- Infant
- Premature
- Language Development
- Male
- Perinatal Care
- Premature Birth
- Prognosis
- Prospective Studies
- Severity of Illness Index
- Survivors
- Sweden
- Treatment Outcome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Serenius, Fredri ...
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Källén, Karin
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Blennow, Mats
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Ewald, Uwe, 1945 ...
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Fellman, Vineta
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Holmström, Gerd
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visa fler...
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Lindberg, Eva
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Lundqvist, Pia
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Marsal, Karel
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Norman, Mikael
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Olhager, Elisabe ...
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Stigson, Lennart
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Stjernqvist, Kar ...
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Vollmer, Brigitt ...
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Strömberg, Bo, 1 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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Journal of the A ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet
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Uppsala universitet
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Umeå universitet
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Linköpings universitet
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Karolinska Institutet