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Total zinc intake m...
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant : a 14-cohort meta-analysis
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Kanoni, Stavroula (author)
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Nettleton, Jennifer A (author)
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Hivert, Marie-France (author)
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show more...
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Ye, Zheng (author)
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van Rooij, Frank JA (author)
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- Shungin, Dmitry (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Institutionen för odontologi,Department of Clinical Sciences, Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Ngwa, Julius S (author)
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Wojczynski, Mary K (author)
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Lemaitre, Rozenn N (author)
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Gustafsson, Stefan (author)
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Anderson, Jennifer S (author)
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Tanaka, Toshiko (author)
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- Hindy, George (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Saylor, Georgia (author)
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- Renström, Frida (author)
- Umeå universitet,Medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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Bennett, Amanda J (author)
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van Duijn, Cornelia M (author)
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Florez, Jose C (author)
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Fox, Caroline S (author)
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Hofman, Albert (author)
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Hoogeveen, Ron C (author)
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Houston, Denise K (author)
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Hu, Frank B (author)
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- Franks, Paul (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin
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Liu, Yongmei (author)
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McKeown, Nicola (author)
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Ordovas, Jose (author)
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Pankow, James S (author)
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Sijbrands, Eric JG (author)
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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Uitterlinden, André G (author)
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Yannakoulia, Mary (author)
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Zillikens, M Carola (author)
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Wareham, Nick J (author)
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Prokopenko, Inga (author)
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Bandinelli, Stefania (author)
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Forouhi, Nita G (author)
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Cupples, L Adrienne (author)
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Loos, Ruth J (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Medicin
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Dupuis, Josée (author)
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Langenberg, Claudia (author)
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Ferrucci, Luigi (author)
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Kritchevsky, Stephen B (author)
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McCarthy, Mark I (author)
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- Ingelsson, Erik (author)
- Karolinska Institutet
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Borecki, Ingrid B (author)
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Witteman, Jacqueline CM (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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Siscovick, David S (author)
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Meigs, James B (author)
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- Franks, Paul W (author)
- Umeå universitet,Medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
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Dedoussis, George V (author)
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(creator_code:org_t)
- 2011-08-20
- 2011
- English.
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In: Diabetes. - Alexandria : American diabetes association. - 0012-1797 .- 1939-327X. ; 60:9, s. 2407-2416
- Related links:
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https://diabetes.dia...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
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- OBJECTIVE Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants.RESEARCH DESIGN AND METHODS We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes.RESULTS We observed a significant association of total zinc intake with lower fasting glucose levels (β-coefficient ± SE per 1 mg/day of zinc intake: -0.0012 ± 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant.CONCLUSIONS Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- genome-wide association
- gene-environment interactions
- risk loci
- insulin resistance
- cell-function
- homeostasis
- supplementation
- ZNT8
- polymorphisms
- expression
Publication and Content Type
- ref (subject category)
- art (subject category)
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Diabetes
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- By the author/editor
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Kanoni, Stavroul ...
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Nettleton, Jenni ...
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Hivert, Marie-Fr ...
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Ye, Zheng
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van Rooij, Frank ...
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Shungin, Dmitry
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show more...
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Sonestedt, Emily
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Ngwa, Julius S
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Wojczynski, Mary ...
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Lemaitre, Rozenn ...
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Gustafsson, Stef ...
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Anderson, Jennif ...
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Tanaka, Toshiko
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Hindy, George
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Saylor, Georgia
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Renström, Frida
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Bennett, Amanda ...
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van Duijn, Corne ...
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Florez, Jose C
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Fox, Caroline S
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Hofman, Albert
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Hoogeveen, Ron C
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Houston, Denise ...
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Hu, Frank B
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Franks, Paul
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Johansson, Ingeg ...
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Lind, Lars
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Liu, Yongmei
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McKeown, Nicola
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Ordovas, Jose
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Pankow, James S
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Sijbrands, Eric ...
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Syvänen, Ann-Chr ...
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Uitterlinden, An ...
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Yannakoulia, Mar ...
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Zillikens, M Car ...
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Wareham, Nick J
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Prokopenko, Inga
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Bandinelli, Stef ...
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Forouhi, Nita G
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Cupples, L Adrie ...
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Loos, Ruth J
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Hallmans, Göran
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Dupuis, Josée
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Langenberg, Clau ...
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Ferrucci, Luigi
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Kritchevsky, Ste ...
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McCarthy, Mark I
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Ingelsson, Erik
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Borecki, Ingrid ...
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Witteman, Jacque ...
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Orho-Melander, M ...
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Siscovick, David ...
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Meigs, James B
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Franks, Paul W
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Dedoussis, Georg ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes
- By the university
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Umeå University
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Uppsala University
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Lund University
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Karolinska Institutet