SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Hosseini A) ;pers:(Hosseini A)"

Sökning: WFRF:(Hosseini A) > Hosseini A

  • Resultat 1-10 av 107
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  • Therriault, J., et al. (författare)
  • Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease
  • 2023
  • Ingår i: Alzheimers & Dementia. - 1552-5260. ; 19:11, s. 4967-4977
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: Plasma biomarkers are promising tools for Alzheimer's disease (AD) diagnosis, but comparisons with more established biomarkers are needed.METHODS: We assessed the diagnostic performance of p-tau(181), p-tau(217), and p-tau(231) in plasma and CSF in 174 individuals evaluated by dementia specialists and assessed with amyloid-PET and tau-PET. Receiver operating characteristic (ROC) analyses assessed the performance of plasma and CSF biomarkers to identify amyloid-PET and tau-PET positivity.RESULTS: Plasma p-tau biomarkers had lower dynamic ranges and effect sizes compared to CSF p-tau. Plasma p-tau(181) (AUC = 76%) and p-tau(231) (AUC = 82%) assessments performed inferior to CSF p-tau(181) (AUC = 87%) and p-tau(231) (AUC = 95%) for amyloid-PET positivity. However, plasma p-tau(217) (AUC = 91%) had diagnostic performance indistinguishable from CSF (AUC = 94%) for amyloid-PET positivity.DISCUSSION: Plasma and CSF p-tau(217) had equivalent diagnostic performance for biomarker-defined AD. Our results suggest that plasma p-tau(217) may help reduce the need for invasive lumbar punctures without compromising accuracy in the identification of AD.
  •  
9.
  • Woo, M. S., et al. (författare)
  • 14-3-3 ζ/δ-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2
  • 2023
  • Ingår i: Journal of Neuroinflammation. - 1742-2094. ; 20:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer's disease (AD). However, synaptic damage happens early in AD at the very early stages of tau accumulation. It remains unclear whether microglia activation independently causes synaptic cleavage before tau aggregation appears.Methods We investigated 104 participants across the AD continuum by measuring 14-3-3 zeta/delta (zeta/delta) as a cerebrospinal fluid biomarker for synaptic degradation, and fluid and imaging biomarkers of tau, amyloidosis, astrogliosis, neurodegeneration, and inflammation. We performed correlation analyses in cognitively unimpaired and impaired participants and used structural equation models to estimate the impact of microglia activation on synaptic injury in different disease stages.Results14-3-3 zeta/delta was increased in participants with amyloid pathology at the early stages of tau aggregation before hippocampal volume loss was detectable. 14-3-3 zeta/delta correlated with amyloidosis and tau load in all participants but only with biomarkers of neurodegeneration and memory deficits in cognitively unimpaired participants. This early synaptic damage was independently mediated by sTREM2. At later disease stages, tau and astrogliosis additionally mediated synaptic loss.ConclusionsOur results advertise that sTREM2 is mediating synaptic injury at the early stages of tau accumulation, underlining the importance of microglia activation for AD disease propagation.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 107
Typ av publikation
tidskriftsartikel (93)
konferensbidrag (13)
rapport (1)
Typ av innehåll
refereegranskat (92)
övrigt vetenskapligt/konstnärligt (15)
Författare/redaktör
Hosseini, A. (92)
Wiklund, P (29)
Adding, C (25)
Wiklund, NP (21)
Mottrie, A (17)
Collins, JW (13)
visa fler...
Nyberg, T (12)
Dasgupta, P. (12)
Guru, KA (12)
Wijburg, C (12)
Hussein, AA (12)
Khan, MS (11)
Ströck, Viveka (10)
Laurin, O (10)
Canda, AE (10)
Collins, J (9)
Ullen, A (9)
Wiklund, PN (9)
Schumacher, MC (9)
D'Hondt, F (9)
Liedberg, Fredrik (8)
Jahnson, Staffan (8)
Gardmark, T. (8)
Stockle, M (8)
Rha, KH (8)
Sherif, Amir (7)
Häggström, Christel (7)
Malmström, Per-Uno (7)
Hagberg, Oskar (7)
Carlsson, S (7)
Richstone, L (7)
Kaouk, J (7)
Jing, Z (7)
Edeling, S (7)
Nilsson, A (6)
Jerlström, Tomas, 19 ... (6)
Holmberg, Lars (6)
Kelly, J (6)
Steineck, G (6)
Menon, M (6)
Peabody, JO (6)
Akre, O (6)
Hemal, A (6)
Elsayed, AS (6)
Gaboardi, F (6)
Maatman, TJ (6)
Mehrazin, R (6)
Dey, L (6)
Decaestecker, K (6)
Sanchez-Salas, R (6)
visa färre...
Lärosäte
Karolinska Institutet (87)
Göteborgs universitet (14)
Uppsala universitet (12)
Linköpings universitet (9)
Lunds universitet (9)
Umeå universitet (8)
visa fler...
Örebro universitet (7)
Högskolan Väst (3)
Kungliga Tekniska Högskolan (2)
Mittuniversitetet (2)
RISE (2)
Luleå tekniska universitet (1)
Södertörns högskola (1)
Chalmers tekniska högskola (1)
visa färre...
Språk
Engelska (107)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (20)
Teknik (8)
Naturvetenskap (5)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy