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Genome-wide associa...
Genome-wide association study identifies five susceptibility loci for glioma.
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- Shete, Sanjay (author)
- Karolinska Institutet
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Hosking, Fay J (author)
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Robertson, Lindsay B (author)
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show more...
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Dobbins, Sara E (author)
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Sanson, Marc (author)
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- Malmer, Beatrice (author)
- Umeå universitet,Onkologi
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Simon, Matthias (author)
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Marie, Yannick (author)
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Boisselier, Blandine (author)
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Delattre, Jean-Yves (author)
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Hoang-Xuan, Khe (author)
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El Hallani, Soufiane (author)
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Idbaih, Ahmed (author)
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Zelenika, Diana (author)
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- Andersson, Ulrika (author)
- Umeå universitet,Onkologi
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- Henriksson, Roger (author)
- Umeå universitet,Onkologi
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- Bergenheim, A Tommy (author)
- Karolinska Institutet,Umeå universitet,Neurokirurgi
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- Feychting, Maria (author)
- Karolinska Institutet
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Lönn, Stefan (author)
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Ahlbom, Anders (author)
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Schramm, Johannes (author)
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Linnebank, Michael (author)
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Hemminki, Kari (author)
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Kumar, Rajiv (author)
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Hepworth, Sarah J (author)
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Price, Amy (author)
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Armstrong, Georgina (author)
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Liu, Yanhong (author)
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Gu, Xiangjun (author)
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Yu, Robert (author)
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Lau, Ching (author)
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Schoemaker, Minouk (author)
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Muir, Kenneth (author)
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Swerdlow, Anthony (author)
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Lathrop, Mark (author)
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Bondy, Melissa (author)
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Houlston, Richard S (author)
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(creator_code:org_t)
- 2009-07-05
- 2009
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41:8, s. 899-904
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Shete, Sanjay
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Hosking, Fay J
-
Robertson, Linds ...
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Dobbins, Sara E
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Sanson, Marc
-
Malmer, Beatrice
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show more...
-
Simon, Matthias
-
Marie, Yannick
-
Boisselier, Blan ...
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Delattre, Jean-Y ...
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Hoang-Xuan, Khe
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El Hallani, Souf ...
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Idbaih, Ahmed
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Zelenika, Diana
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Andersson, Ulrik ...
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Henriksson, Roge ...
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Bergenheim, A To ...
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Feychting, Maria
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Lönn, Stefan
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Ahlbom, Anders
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Schramm, Johanne ...
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Linnebank, Micha ...
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Hemminki, Kari
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Kumar, Rajiv
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Hepworth, Sarah ...
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Price, Amy
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Armstrong, Georg ...
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Liu, Yanhong
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Gu, Xiangjun
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Yu, Robert
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Lau, Ching
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Schoemaker, Mino ...
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Muir, Kenneth
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Swerdlow, Anthon ...
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Lathrop, Mark
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Bondy, Melissa
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Houlston, Richar ...
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show less...
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University
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Karolinska Institutet