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Träfflista för sökning "WFRF:(Hovland Anders) "

Sökning: WFRF:(Hovland Anders)

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  • Titov, Nickolai, et al. (författare)
  • ICBT in routine care : A descriptive analysis of successful clinics in five countries
  • 2018
  • Ingår i: Internet Interventions. - : Elsevier. - 2214-7829. ; 13, s. 108-115
  • Forskningsöversikt (refereegranskat)abstract
    • Clinical trials have demonstrated the efficacy of internet delivered cognitive behaviour therapy (ICBT) for anxiety and depression. However, relatively little is known about the context, operations, and outcomes of ICBT when administered as part of routine care. This paper describes the setting, relationship to existing health services, procedures for referral, assessment, treatment, patients and outcomes of ICBT clinics in Sweden, Denmark, Norway, Canada and Australia. All five clinics provide services free or at low cost to patients. All have systems of governance to monitor quality of care, patient safety, therapist performance and data security. All five clinics include initial assessments by clinicians and between 10 and 20 min of therapist support during each week. Published reports of outcomes all demonstrate large clinical improvement, low rates of deterioration, and high levels of patient satisfaction. Services that require a face to face assessment treat smaller numbers of patients and have fewer patients from remote locations. The paper shows that therapist-guided ICBT can be a valuable part of mental health services for anxiety and depression. Important components of successful ICBT services are rigorous governance to maintain a high standard of clinical care, and the measurement and reporting of outcomes.
  • Andersson, Eva, 1958-, et al. (författare)
  • Fysisk aktivitet lika bra som KBT eller läkemedel vid depression
  • 2015
  • Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; :47, s. 2102-2104
  • Tidskriftsartikel (refereegranskat)abstract
    • Fyisk aktivitet har dokumenterad effekt vid depression. Effekten är lika god som effekten av antidepressiva läkemedel eller kognitiv beteendeterapi (KBT) vid lindrig till måttlig depression. Dessutom är fysisk aktivitet i stort sett biverkningsfritt.
  • Hovland, Anders, et al. (författare)
  • Fysisk aktivitet vid ångestsyndrom
  • 2016
  • Ingår i: FYSS 2017. - : Läkartidningen förlag. - 9789198171129 ; , s. 632-643
  • Bokkapitel (övrigt vetenskapligt)abstract
    • Sammanfattande rekommendationPersoner med panikångest bör rekommenderas aerob fysisk aktivitet för att minska ångest. Måttligt starkt vetenskapligt underlag (evidensstyrka +++).Ett enstaka aerobt träningspass på hög intensitet minskar risken att utlösa panikångest. Måttligt starkt vetenskapligt underlag (evidensstyrka +++).Fysisk aktivitet kan användas som kompletterande behandling vid all form av ångest, då det finns grund för att förvänta en viss symtomreduktion både akut och på längre sikt.Den fysiska aktiviteten bör utformas och individanpassas av medicinskt utbildad personal i samråd med individen.Personer med ångest, oavsett typ, bör även rekommenderas muskelstärkande fysisk aktivitet enligt de allmänna rekommendationerna om fysisk aktivitet.
  • Hovland, Anders, et al. (författare)
  • The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
  • 2015
  • Ingår i: Atherosclerosis. - : ELSEVIER IRELAND LTD. - 0021-9150 .- 1879-1484. ; 241:2, s. 480-494
  • Forskningsöversikt (refereegranskat)abstract
    • Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier research focus on adaptive immunity has gradually switched towards the role of innate immunity. The complement system and toll-like receptors (TLRs), and the crosstalk between them, may be of particular interest both with respect to pathogenesis and as therapeutic targets in atherosclerosis. Animal studies indicate that inhibition of C3a and C5a reduces atherosclerosis. In humans modified LDL-cholesterol activate complement and TLRs leading to downstream inflammation, and histopathological studies indicate that the innate immune system is present in atherosclerotic lesions. Moreover, clinical studies have demonstrated that both complement and TLRs are upregulated in atherosclerotic diseases, although interventional trials have this far been disappointing. However, based on recent research showing an intimate interplay between complement and TLRs we propose a model in which combined inhibition of both complement and TLRs may represent a potent anti-inflammatory therapeutic approach to reduce atherosclerosis. (C) 2015 The Authors. Published by Elsevier Ireland Ltd.
  • Kjellmo, Christian Abendstein, et al. (författare)
  • Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol, but has no effect on cholesterol efflux capacity
  • 2018
  • Ingår i: Journal of Clinical Lipidology. - : ELSEVIER SCIENCE INC. - 1933-2874 .- 1876-4789. ; 12:1, s. 193-202
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Bariatric surgery has been shown to reduce cardiovascular events and cause specific mortality for coronary artery disease in obese patients. Lipoprotein biomarkers relating to low-density lipoprotein (LDL), high-density lipoprotein (HDL), their subfractions, and macrophage cholesterol efflux have all been hypothesized to be of value in cardiovascular risk assessment. OBJECTIVES: The objective of this study was to examine the effect of a lifestyle intervention followed by bariatric surgery on the lipid profile of morbidly obese patients. METHODS: Thirty-four morbidly obese patients were evaluated before and after lifestyle changes and then 1 year after bariatric surgery. They were compared with 17 lean subjects. Several lipoprotein metrics, serum amyloid A (SAA), serum paraoxonase-1 (PON1), and macrophage cholesterol efflux capacity (CEC) were assessed. RESULTS: Average weight loss after the lifestyle intervention was 10.5% and 1 year after bariatric surgery was 33.9%. The lifestyle intervention significantly decreased triglycerides (TGs; 28.7 mg/dL, P amp;lt; .05), LDL cholesterol (LDL-C; 32.3 mg/dL, P amp;lt; .0001), and apolipoprotein B (apoB; 62.9 mu g/mL, P amp;lt; .001). Bariatric surgery further reduced TGs (-36.7 mg/dL, P amp;lt; .05), increased HDL cholesterol (+12 mg/dL, P amp;lt; .0001), and reductions in LDL-C and apoB were sustained. Bariatric surgery reduced large, buoyant LDL (P amp;lt; .0001), but had no effect on the small, dense LDL.The large HDL subfractions increased (P amp;lt; .0001), but there was no effect on the smaller HDL sub fractions. The ratio for SAA/PON1 was reduced after the lifestyle intervention (P amp;lt; .01) and further reduced after bariatric surgery (P amp;lt; .0001). Neither the lifestyle intervention nor bariatric surgery had any effect on CEC. CONCLUSIONS: Lifestyle intervention followed by bariatric surgery in 34 morbidly obese patients showed favorable effects on TGs, LDL-C, and apoB. HDL cholesterol and apoA1 was increased, apoB/apoA1 ratio as well as SAA/PON1 ratio reduced, but bariatric surgery did not influence CEC. (C) 2017 National Lipid Association. All rights reserved.
  • Lappegard, Knut T., et al. (författare)
  • A vital role for complement in heart disease
  • 2014
  • Ingår i: Molecular Immunology. - : Elsevier. - 0161-5890 .- 1872-9142. ; 61:2, s. 126-134
  • Forskningsöversikt (refereegranskat)abstract
    • Heart diseases are common and significant contributors to worldwide mortality and morbidity. During recent years complement mediated inflammation has been shown to be an important player in a variety of heart diseases. Despite some negative results from clinical trials using complement inhibitors, emerging evidence points to an association between the complement system and heart diseases. Thus, complement seems to be important in coronary heart disease as well as in heart failure, where several studies underscore the prognostic importance of complement activation. Furthermore, patients with atrial fibrillation often share risk factors both with coronary heart disease and heart failure, and there is some evidence implicating complement activation in atrial fibrillation. Moreover, Chagas heart disease, a protozoal infection, is an important cause of heart failure in Latin America, and the complement system is crucial for the protozoa-host interaction. Thus, complement activation appears to be involved in the pathophysiology of a diverse range of cardiac conditions. Determination of the exact role of complement in the various heart diseases will hopefully help to identify patients that might benefit from therapeutic complement intervention.
  • Lappegård, Knut Tore, et al. (författare)
  • Lipoprotein apheresis affects lipoprotein particle subclasses more efficiently compared to the PCSK9 inhibitor evolocumab, a pilot study.
  • 2018
  • Ingår i: Transfusion and apheresis science. - 1473-0502 .- 1878-1683. ; 57:1, s. 91-96
  • Tidskriftsartikel (refereegranskat)abstract
    • Lipoprotein apheresis and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are last therapeutic resorts in patients with familial hypercholesterolemia (FH). We explored changes in lipoprotein subclasses and high-density lipoprotein (HDL) function when changing treatment from lipoprotein apheresis to PCSK9 inhibition. We measured the levels of low-density lipoprotein (LDL) and HDL particle subclasses, serum amyloid A1 (SAA1), paraoxonase-1 (PON1) activity and cholesterol efflux capacity (CEC) in three heterozygous FH patients. Concentrations of all LDL particle subclasses were reduced during apheresis (large 68.0 ± 17.5 to 16.3 ± 2.1 mg/dL, (p = 0.03), intermediate 38.3 ± 0.6 to 5.0 ± 3.5 mg/dL (p = 0.004) and small 5.0 ± 2.6 to 0.2 ± 0.1 mg/dL (p = 0.08)). There were non-significant reductions in the LDL subclasses during evolocumab treatment. There were non-significant reductions in subclasses of HDL particles during apheresis, and no changes during evolocumab treatment. CEC was unchanged throughout the study, while the SAA1/PON1 ratio was unchanged during apheresis but decreased during evolocumab treatment. In conclusion, there were significant reductions in large and intermediate size LDL particles during apheresis, and a non-significant reduction in small LDL particles. There were only non-significant reductions in the LDL subclasses during evolocumab treatment.
  • Martinsen, Egil, et al. (författare)
  • Fysisk aktivitet vid depression
  • 2015
  • Ingår i: ; , s. 1-12
  • Bokkapitel (populärvet., debatt m.m.)abstract
    • Fysisk aktivitet kan förebygga insjuknande och återsjuknande i depression.Enbart fysisk träning har klart vetenskapligt stöd när det gäller behandling vid lindrig och måttlig depression.Fysisk träning som tillägg till sedvanlig behandling i form av samtal och mediciner ger en förstärkt effekt.Fysisk aktivitet har utöver effekt på depression också en gynnsam effekt på vanliga komorbida tillstånd, som typ 2-diabetes och hjärt-kärlsjukdom.Personer med depression bör rekommenderas fysisk aktivitet som tillägg till samtalsterapi och läkemedel.
  • Martinsen, Egil W, et al. (författare)
  • Fysisk aktivitet vid depression
  • 2016
  • Ingår i: FYSS 2017. - : Läkartidningen förlag. - 9789198171129 ; , s. 362-370
  • Bokkapitel (övrigt vetenskapligt)abstract
    • Sammanfattande rekommendationPersoner med depression bör rekommenderas aerob eller muskelstärkande fysisk aktivitet för att minska depressiva symtom, måttligt starkt vetenskapligt underlag (evidensstyrka +++), och förbättra livskvalitet, begränsat vetenskapligt underlag (evidensstyrka ++).Vid lindrig eller måttlig depression reducerar fysisk aktivitet depressiva symtom i liknande grad som antidepressiva läkemedel eller kognitiv beteendeterapi (KBT). Måttligt starkt vetenskapligt underlag (evidensstyrka +++).Om enbart muskelstärkande fysisk aktivitet väljs i syfte att behandla depression, bör den kompletteras med aerob fysisk aktivitet för att minska risken för hjärt-kärlsjukdom, eftersom denna risk är förhöjd vid depression.
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