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Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.
- Domchek, Susan M (author)
- Aghajanian, Carol (author)
- Shapira-Frommer, Ronnie (author)
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- Schmutzler, Rita K (author)
- Audeh, M William (author)
- Friedlander, Michael (author)
- Balmaña, Judith (author)
- Mitchell, Gillian (author)
- Fried, Georgeta (author)
- Stemmer, Salomon M (author)
- Hubert, Ayala (author)
- Rosengarten, Ora (author)
- Robertson, Jane D (author)
- Mann, Helen (author)
- Kaufman, Bella (author)
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- (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
- In: Gynecologic Oncology. - : Elsevier BV. - 1095-6859 .- 0090-8258. ; 140:2, s. 199-203
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The efficacy and safety of olaparib, an oral poly(ADP-ribose) polymerase (PARP) inhibitor, was investigated in a subgroup of patients with germline BRCA1/2 mutated (gBRCA1/2m) advanced ovarian cancer who had received ≥3 prior lines of chemotherapy. Primary data from this Phase II study (Study 42, ClinicalTrials.govNCT01078662) have been reported previously.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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