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Genetic control of ...
Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice
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- Forster, M. (författare)
- Karolinska Institutet, Stockholm, Sweden
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- Raposo, B. (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Ekman, D. (författare)
- Karolinska Institutet, Stockholm, Sweden
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- Klaczkowska, D. (författare)
- Karolinska Institutet, Stockholm, Sweden
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- Popovic, M. (författare)
- Karolinska Institutet, Stockholm, Sweden
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- Nandakumar, Kutty Selva, 1965- (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Lindvall, Therese (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Hultqvist, Malin (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Teneva, Ivanka (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Johannesson, M. (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden
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- Holmdahl, Rikard (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2012-10-27
- 2012
- Engelska.
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Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 71
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://ard.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To identify genetic factors driving pathogenic autoantibody formation in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), in order to better understand the etiology of RA and identify possible new avenues for therapeutic intervention. METHODS: We performed a genome-wide analysis of quantitative trait loci controlling autoantibody to type II collagen (anti-CII), anti-citrullinated protein antibody (ACPA), and rheumatoid factor (RF). To identify loci controlling autoantibody production, we induced CIA in a heterogeneous stock-derived mouse cohort, with contribution of 8 inbred mouse strains backcrossed to C57BL/10.Q. Serum samples were collected from 1,640 mice before arthritis onset and at the peak of the disease. Antibody concentrations were measured by standard enzyme-linked immunosorbent assay, and linkage analysis was performed using a linear regression-based method. RESULTS: We identified loci controlling formation of anti-CII of different IgG isotypes (IgG1, IgG3), antibodies to major CII epitopes (C1, J1, U1), antibodies to a citrullinated CII peptide (citC1), and RF. The anti-CII, ACPA, and RF responses were all found to be controlled by distinct genes, one of the most important loci being the immunoglobulin heavy chain locus. CONCLUSION: This comprehensive genetic analysis of autoantibody formation in CIA demonstrates an association not only of anti-CII, but interestingly also of ACPA and RF, with arthritis development in mice. These results underscore the importance of non-major histocompatibility complex genes in controlling the formation of clinically relevant autoantibodies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Animals
- Arthritis
- Experimental/*genetics/*immunology
- Arthritis
- Rheumatoid/genetics/immunology
- Autoantibodies/blood/*genetics/*immunology
- Collagen Type II/immunology
- Disease Models
- Animal
- Female
- Genome-Wide Association Study
- Immunoglobulin G/blood/genetics/immunology
- Male
- Mice
- Mice
- Inbred A
- Mice
- Inbred AKR
- Mice
- Inbred BALB C
- Mice
- Inbred C3H
- Mice
- Inbred C57BL
- Mice
- Inbred CBA
- Mice
- Inbred DBA
- Peptides
- Cyclic/immunology
- Quantitative Trait Loci/immunology
- Rheumatoid Factor/immunology
- Species Specificity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Forster, M.
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Raposo, B.
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Ekman, D.
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Klaczkowska, D.
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Popovic, M.
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Nandakumar, Kutt ...
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visa fler...
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Lindvall, Theres ...
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Hultqvist, Malin
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Teneva, Ivanka
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Johannesson, M.
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Ahlqvist, Emma
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Holmdahl, Rikard
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Arthritis and Rh ...
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JOURNAL OF IMMUN ...
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ANNALS OF THE RH ...
- Av lärosätet
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Högskolan i Halmstad
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Lunds universitet
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Karolinska Institutet