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The extreme male br...
The extreme male brain revisited: gender coherence in adults with autism spectrum disorder
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- Bejerot, Susanne, 1955- (författare)
- Karolinska Institutet
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- Eriksson, J. M. (författare)
- Karolinska Institutet
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- Bonde, S. (författare)
- Northern Stockholm Psychiatry, St Göran Hospital, Stockholm, Sweden
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- Canstrom, K. (författare)
- Department of Woman and Child Health, Division of Obstetrics and Gynaecology, Karolinska Institutet, Stockholm, Sweden
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- Humble, Mats B., 1952- (författare)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Neuroscience, Uppsala University Hospital, Uppsala, Sweden
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- Eriksson, Elias, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Pharmacology, Institute of Neuroscience and Physiology, Göteborg, Sweden
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(creator_code:org_t)
- 2018-01-02
- 2012
- Engelska.
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Ingår i: British Journal of Psychiatry. - London, United Kingdom : Royal College of Psychiatrists. - 0007-1250 .- 1472-1465. ; 201:2, s. 116-123
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background The 'extreme male brain' theory suggests that autism spectrum disorder (ASD) is an extreme variant of male intelligence. However, somewhat paradoxically, many individuals with ASD display androgynous physical features regardless of gender. Aims To assess physical measures, supposedly related to androgen influence, in adults with and without ASD. Method Serum hormone levels, anthropometry, the ratio of 2nd to 4th digit length (2D:4D) and psychiatric symptomatology were measured in 50 adults with high-functioning ASD and age- and gender-matched neurotypical controls. Photographs of face and body, as well as voice recordings, were obtained and assessed with respect to gender coherence, blindly and independently, by eight assessors. Results Women with ASD had higher total and bioactive testosterone levels, less feminine facial features and a larger head circumference than female controls. Men in the ASD group were assessed as having less masculine body characteristics and voice quality, and displayed higher (i.e. less masculine) 2D:4D ratios, but similar testosterone levels to controls. Androgynous facial features correlated strongly and positively with autistic traits measured with the Autism-Spectrum Quotient in the total sample. In males and females with ASD dehydroepiandrosterone sulfate did not decrease with age, in contrast to the control group. Conclusions Women with ASD had elevated testosterone levels and several masculinised characteristics compared with controls, whereas men with ASD displayed several feminised characteristics. Our findings suggest that ASD, rather than being characterised by masculinisation in both genders, may constitute a gender defiant disorder.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- fetal testosterone
- functioning autism
- sex-differences
- length ratios
- voice pitch
- oxytocin
- vasopressin
- challenge
- children
- behavior
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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