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Träfflista för sökning "WFRF:(Huss Mikael) "

Sökning: WFRF:(Huss Mikael)

  • Resultat 1-10 av 83
  • [1]234567...9Nästa
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1.
  • Matsson, Hans, et al. (författare)
  • Polymorphisms in DCDC2 and S100B associate with developmental dyslexia
  • 2015
  • Ingår i: Journal of Human Genetics. - Springer. - 1434-5161. ; 60:7, s. 399-401
  • Tidskriftsartikel (refereegranskat)abstract
    • Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify single-nucleotide polymorphisms in the exons of these 11 genes in pools of 100 DNA samples of Finnish individuals with developmental dyslexia. Subsequent individual genotyping of those 100 individuals, and additional cases and controls from the Finnish and German populations, validated 92 out of 111 different single-nucleotide variants. A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (corrected P = 0.016) showed a significant association with spelling performance in families of German origin. No significant association was found for the variants neither in the Finnish case-control sample set nor in the Finnish family sample set. Our findings further strengthen the role of DCDC2 and implicate S100B, in the biology of reading and spelling.
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2.
  • Ovegård, Erik, et al. (författare)
  • Operational Guidance with Respect to Pure Loss of Stability and Parametric Rolling
  • 2012
  • Ingår i: Proceedings of the 11<sup>th</sup> International Conference on the Stability of Ships and Ocean Vehicles (STAB2012).
  • Konferensbidrag (refereegranskat)abstract
    • <p>This paper reviews two previously presented simplified methods for assessment of pure loss of stability and parametric rolling based on linear signal theory. The methods are evaluated in relation to full-scale incidents and time-domain simulations. Underlying assumptions and tuning of the critical levels in the simplified methods with reference to time-domain simulations is discussed. Given proper tuning the methods are concluded to provide a feasible basis for ship specific on-board operational guidance.</p>
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4.
  • Rosén, Anders, et al. (författare)
  • Experience from Parametric Rolling of Ships
  • 2012
  • Ingår i: Parametric Resonance in Dynamical Systems. - Springer. - 978-1-4614-1042-3 ; s. 147-165
  • Bokkapitel (refereegranskat)abstract
    • <p>This chapter reviews three recent full-scale events with parametric rolling for Ro–Ro Large Car and Truck Carriers (LCTC). The events represent three principally different modes of parametric rolling: principal parametric resonance where the period of encounter is half of the roll natural period in following seas (I) and in head seas (II), and fundamental parametric resonance where the period of encounter coincides with the roll natural period in following seas (III). Roll motion, course, and speed recorded during the events are presented and analyzed together with the present weather situation based on recordings, forecasts, and re-analysis. Different aspects of on-board operational guidance for assisting crews in avoiding parametric rolling are discussed in relation to the presented events. Involved complexities and considerations that are normally not included in well defined model tests or numerical simulations are exposed.</p>
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5.
  • Avican, Kemal, et al. (författare)
  • Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis
  • 2015
  • Ingår i: PLoS Pathogens. - 1553-7366 .- 1553-7374. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. We performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine strategies associated with persistence. Comprehensive analysis of mixed RNA populations from infected tissues revealed that Y. pseudotuberculosis undergoes transcriptional reprogramming with drastic down-regulation of T3SS virulence genes during persistence when the pathogen resides within the cecum. At the persistent stage, the expression pattern in many respects resembles the pattern seen in vitro at 26oC, with for example, up-regulation of flagellar genes and invA. These findings are expected to have impact on future rationales to identify suitable bacterial targets for new antibiotics. Other genes that are up-regulated during persistence are genes involved in anaerobiosis, chemotaxis, and protection against oxidative and acidic stress, which indicates the influence of different environmental cues. We found that the Crp/CsrA/RovA regulatory cascades influence the pattern of bacterial gene expression during persistence. Furthermore, arcA, fnr, frdA, and wrbA play critical roles in persistence. Our findings suggest a model for the life cycle of this enteropathogen with reprogramming from a virulent to an adapted phenotype capable of persisting and spreading by fecal shedding.</p>
6.
  • Avican, Kemal, et al. (författare)
  • Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis
  • 2015
  • Ingår i: PLoS Pathogens. - 1553-7366 .- 1553-7374. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. We performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine strategies associated with persistence. Comprehensive analysis of mixed RNA populations from infected tissues revealed that Y. pseudotuberculosis undergoes transcriptional reprogramming with drastic down-regulation of T3SS virulence genes during persistence when the pathogen resides within the cecum. At the persistent stage, the expression pattern in many respects resembles the pattern seen in vitro at 26oC, with for example, up-regulation of flagellar genes and invA. These findings are expected to have impact on future rationales to identify suitable bacterial targets for new antibiotics. Other genes that are up-regulated during persistence are genes involved in anaerobiosis, chemotaxis, and protection against oxidative and acidic stress, which indicates the influence of different environmental cues. We found that the Crp/CsrA/RovA regulatory cascades influence the pattern of bacterial gene expression during persistence. Furthermore, arcA, fnr, frdA, and wrbA play critical roles in persistence. Our findings suggest a model for the life cycle of this enteropathogen with reprogramming from a virulent to an adapted phenotype capable of persisting and spreading by fecal shedding.</p>
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7.
  • Bengtsson-Palme, Johan, 1985-, et al. (författare)
  • The human gut microbiome as a transporter of antibiotic resistance genes between continents
  • 2015
  • Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804. ; 59:10, s. 6551-6560
  • Tidskriftsartikel (refereegranskat)abstract
    • Previous studies of antibiotic resistance dissemination by travel have, by targeting only a select number of cultivable bacterial species, omitted most of the human microbiome. Here, we used explorative shotgun metagenomic sequencing to address the abundance of >300 antibiotic resistance genes in fecal specimens from 35 Swedish students taken before and after exchange programs on the Indian peninsula or in Central Africa. All specimens were additionally cultured for extended-spectrum beta-lactamase (ESBL)-producing enterobacteria, and the isolates obtained were genome sequenced. The overall taxonomic diversity and composition of the gut microbiome remained stable before and after travel, but there was an increasing abundance of Proteobacteria in 25/35 students. The relative abundance of antibiotic resistance genes increased, most prominently for genes encoding resistance to sulfonamide (2.6-fold increase), trimethoprim (7.7-fold), and beta-lactams (2.6-fold). Importantly, the increase observed occurred without any antibiotic intake. Of 18 students visiting the Indian peninsula, 12 acquired ESBL-producing Escherichia coli, while none returning from Africa were positive. Despite deep sequencing efforts, the sensitivity of metagenomics was not sufficient to detect acquisition of the low-abundant genes responsible for the observed ESBL phenotype. In conclusion, metagenomic sequencing of the intestinal microbiome of Swedish students returning from exchange programs in Central Africa or the Indian peninsula showed increased abundance of genes encoding resistance to widely used antibiotics.
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8.
  • Bengtsson-Palme, Johan, et al. (författare)
  • The Human Gut Microbiome as a Transporter of Antibiotic Resistance Genes between Continents
  • 2015
  • Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 59:10, s. 6551-6560
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Previous studies of antibiotic resistance dissemination by travel have, by targeting only a select number of cultivable bacterial species, omitted most of the human microbiome. Here, we used explorative shotgun metagenomic sequencing to address the abundance of &gt;300 antibiotic resistance genes in fecal specimens from 35 Swedish students taken before and after exchange programs on the Indian peninsula or in Central Africa. All specimens were additionally cultured for extended-spectrum beta-lactamase (ESBL)-producing enterobacteria, and the isolates obtained were genome sequenced. The overall taxonomic diversity and composition of the gut microbiome remained stable before and after travel, but there was an increasing abundance of Proteobacteria in 25/35 students. The relative abundance of antibiotic resistance genes increased, most prominently for genes encoding resistance to sulfonamide (2.6-fold increase), trimethoprim (7.7-fold), and beta-lactams (2.6-fold). Importantly, the increase observed occurred without any antibiotic intake. Of 18 students visiting the Indian peninsula, 12 acquired ESBL-producing Escherichia coli, while none returning from Africa were positive. Despite deep sequencing efforts, the sensitivity of metagenomics was not sufficient to detect acquisition of the low-abundant genes responsible for the observed ESBL phenotype. In conclusion, metagenomic sequencing of the intestinal microbiome of Swedish students returning from exchange programs in Central Africa or the Indian peninsula showed increased abundance of genes encoding resistance to widely used antibiotics.</p>
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9.
  • Bengtsson-Palme, Johan, et al. (författare)
  • The Human Gut Microbiome as a Transporter of Antibiotic Resistance Genes between Continents
  • 2015
  • Ingår i: Antimicrobial Agents and Chemotherapy. - 0066-4804 .- 1098-6596. ; 59:10, s. 6551-6560
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Previous studies of antibiotic resistance dissemination by travel have, by targeting only a select number of cultivable bacterial species, omitted most of the human microbiome. Here, we used explorative shotgun metagenomic sequencing to address the abundance of &gt;300 antibiotic resistance genes in fecal specimens from 35 Swedish students taken before and after exchange programs on the Indian peninsula or in Central Africa. All specimens were additionally cultured for extended-spectrum beta-lactamase (ESBL)-producing enterobacteria, and the isolates obtained were genome sequenced. The overall taxonomic diversity and composition of the gut microbiome remained stable before and after travel, but there was an increasing abundance of Proteobacteria in 25/35 students. The relative abundance of antibiotic resistance genes increased, most prominently for genes encoding resistance to sulfonamide (2.6-fold increase), trimethoprim (7.7-fold), and beta-lactams (2.6-fold). Importantly, the increase observed occurred without any antibiotic intake. Of 18 students visiting the Indian peninsula, 12 acquired ESBL-producing Escherichia coli, while none returning from Africa were positive. Despite deep sequencing efforts, the sensitivity of metagenomics was not sufficient to detect acquisition of the low-abundant genes responsible for the observed ESBL phenotype. In conclusion, metagenomic sequencing of the intestinal microbiome of Swedish students returning from exchange programs in Central Africa or the Indian peninsula showed increased abundance of genes encoding resistance to widely used antibiotics.</p>
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10.
  • Bersani, Cinzia, et al. (författare)
  • Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis
  • 2016
  • Ingår i: OncoTarget. - Impact Journals LLC. - 1949-2553 .- 1949-2553. ; 7:2, s. 1895-1911
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>RNA-binding proteins (RBPs) play important roles in the regulation of gene expression through a variety of post-transcriptional mechanisms. The p53-induced RBP Wig-1 (Zmat3) binds RNA through its zinc finger domains and enhances stability of p53 and N-Myc mRNAs and decreases stability of FAS mRNA. To identify novel Wig-1-bound RNAs, we performed RNA-immunoprecipitation followed by high-throughput sequencing (RIP-Seq) in HCT116 and Saos-2 cells. We identified 286 Wig-1-bound mRNAs common between the two cell lines. Sequence analysis revealed that AU-rich elements (AREs) are highly enriched in the 3'UTR of these Wig-1-bound mRNAs. Network enrichment analysis showed that Wig-1 preferentially binds mRNAs involved in cell cycle regulation. Moreover, we identified a 2D Wig-1 binding motif in HIF1A mRNA. Our findings confirm that Wig-1 is an ARE-BP that regulates cell cycle-related processes and provide a novel view of how Wig-1 may bind mRNA through a putative structural motif. We also significantly extend the repertoire of Wig-1 target mRNAs. Since Wig-1 is a transcriptional target of the tumor suppressor p53, these results have implications for our understanding of p53-dependent stress responses and tumor suppression.</p>
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  • [1]234567...9Nästa
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