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Sökning: WFRF:(Huyghe Jeroen R) > (2010-2014) > Kunst Sylvia J. > Familial aggregatio...

Familial aggregation of pure tone hearing thresholds in an aging European population

Hendrickx, Jan-Jaap (författare)
University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium; Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Huyghe, Jeroen R. (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Topsakal, Vedat (författare)
University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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Demeester, Kelly (författare)
University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
Wienker, Thomas F. (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Laer, Lut Van (författare)
University of Antwerp, Belgium
Eyken, Els Van (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Fransen, Erik (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; StatUa Statistics Center, University of Antwerp, Antwerp, Belgium
Mäki-Torkko, Elina, 1961- (författare)
Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu; and Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland
Hannula, Samuli (författare)
Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland
Parving, Agnete (författare)
Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark
Jensen, Mona (författare)
Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark
Tropitzsch, Anke (författare)
Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany
Bonaconsa, Amanda (författare)
Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy
Mazzoli, Manuela (författare)
Department of Otorhinolaryngology, University of Tubingen, Tubingen, Germany,University Hospital Padova, Italy
Espeso, Angeles (författare)
Department of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK
Verbruggen, Katja (författare)
Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium
Huyghe, Joke (författare)
Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium
Huygen, Patrick L. M. (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre and Donders Institute for Brain, Cognition and Behaviour, the Netherlands
Kremer, Hannie (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands
Kunst, Sylvia J. (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands
Diaz-Lacava, Amalia N. (författare)
Pharmacoepidemiology in Neurodegenerative Disorders, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Steffens, Michael (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Pyykkö, Ilmari (författare)
Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Dhooge, Ingeborg (författare)
Welsh Hearing Institute, University Hospital of Wales, Cardiff, United Kingdom,University Hospital of Gent, Belgium
Stephens, Dafydd (författare)
Department of Otosurgery, University Hospital Padova, Padova, Italy,University Hospital of Wales, Cardiff, UK
Orzan, Eva (författare)
Audiology and Otolaryngology Unit, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
Pfister, Markus H. F. (författare)
Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark,University of Tuebingen, Germany
Bille, Michael (författare)
Department of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, Northern Ostrobothnia Hospital District, Finland,Bispebjerg Hospital, Copenhagen, Denmark
Sorri, Martti (författare)
Institute of Clinical Medicine, Department of Otorhinolaryngology, University of Oulu, Finland,University of Oulu and Oulu University Hospital, Finland
Cremers, Cor W. R. J. (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, Radboud Universiteit Nijmegen Medical Center, Netherlands,Radboud University Nijmegen Medical Centre, the Netherlands
Camp, Guy Van (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
de Heyning, Paul Van (författare)
University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2013
2013
Engelska.
Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 34:5, s. 838-844
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN: Multicenter survey in 8 European centers.SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)

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