| 1. |
- Ahmadi, Shilan Seyed, et al.
(författare)
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Effect of liraglutide on anthropometric measurements, sagittal abdominal diameter and adiponectin levels in people with type 2 diabetes treated with multiple daily insulin injections: evaluations from a randomized trial (MDI-liraglutide study 5)
- 2019
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Ingår i: Obesity Science and Practice. - : Wiley. - 2055-2238. ; 5:2, s. 130-140
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Tidskriftsartikel (refereegranskat)abstract
- Aim Use of the glucagon-like peptide 1 receptor agonist liraglutide has been shown to reduce weight. Different types of anthropometric measurements can be used to measure adiposity. This study evaluated the effect of liraglutide on sagittal abdominal diameter, waist circumference, waist-to-hip ratio and adiponectin levels in people with type 2 diabetes (T2D) treated with multiple daily insulin injections (MDI). Materials and methods In the multicentre, double-blind, placebo-controlled MDI-liraglutide trial, 124 individuals with T2D treated with MDI were randomized to either liraglutide or placebo. Basal values of weight, waist circumference, waist-to-hip ratio, sagittal abdominal diameter and adiponectin were compared with measurements at 12 and 24 weeks after randomization. Results Baseline-adjusted mean weight loss was 3.8 +/- 2.9 kg greater in liraglutide than placebo-treated individuals (p < 0.0001). Waist circumference was reduced by 2.9 +/- 4.3 cm and 0.2 +/- 3.6 cm in the liraglutide and placebo groups, respectively, after 24 weeks (baseline-adjusted mean difference: 2.6 +/- 4.0 cm, p = 0.0005). Corresponding reductions in sagittal abdominal diameter were 1.1 +/- 1.7 cm and 0.0 +/- 1.8 cm (baseline-adjusted mean difference: 1.1 +/- 1.7 cm, p = 0.0008). Hip circumference was reduced in patients randomized to liraglutide (baseline-adjusted mean difference between treatment groups: 2.8 +/- 3.8 cm, p = 0.0001), but there was no significant difference between the groups in either waist-to-hip ratio (baseline-adjusted mean difference: 0.0 +/- 0.04 cm, p = 0.51) or adiponectin levels (baseline-adjusted mean difference: 0.8 +/- 3.3 mg L-1, p = 0.17). Lower HbA1c and mean glucose levels measured by masked continuous glucose monitoring at baseline were associated with greater effects of liraglutide on reductions in waist circumference and sagittal abdominal diameter. Conclusions In patients with T2D, adding liraglutide to MDI may reduce abdominal and hip obesity to a similar extent, suggesting an effect on both visceral and subcutaneous fat. Liraglutide had greater effects on reducing abdominal obesity in patients with less pronounced long-term hyperglycaemia but did not affect adiponectin levels.
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| 2. |
- Gourdon, Mathias, 1980, et al.
(författare)
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Pulp mill biorefineries
- 2013
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Ingår i: International Process Integration Jubilee Conference, Gothenburg, Sweden, March 18-20 2013.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Isaksson, Johan, 1983, et al.
(författare)
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Integration Of Biomass Gasification With A Scandinavian Mechanical Pulp And Paper Mill - Consequences For Mass And Energy Balances And Global CO2 Emissions
- 2012
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Ingår i: Energy. - : Elsevier BV. - 0360-5442. ; 44:1, s. 420-428
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Tidskriftsartikel (refereegranskat)abstract
- The Scandinavian mechanical pulp and paper industry has been facing great challenges during the pastdecades, mainly because of declining demand for newsprint, and higher prices on raw material andenergy. One way of increasing profitability is to produce more value-added products besides theproduction of pulp and paper. In this study, integration potentials of three possible future biomassgasification-based energy mills with an existing thermo-mechanical pulp (TMP) mill, co-located witha sawmill, have been evaluated. The product gas was utilized for electricity production in a gas turbine,for production of methanol or for production of FischereTropsch (FT) liquids. Integration of the energymills showed good potential as the TMP mill constitutes a heat sink for which the excess heat from theenergy mills can be utilized all year round. However, since there is little excess heat from the TMP mill atthe required level to be utilized for biomass drying, for example, heat integration is typically one way. Ithas also been shown that integration of biomass gasification with a TMP mill results in larger CO2emissions reduction than stand-alone operation. Still, compared to co-firing biomass in a coal powerplant, the energy mills all have lower potentials for CO2 emissions reduction.
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