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Celiac disease can ...
Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes
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- Bybrant, M. C. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Uden, E. (author)
- Lund University, Lund, Sweden,Lund Univ, Sweden
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- Frederiksen, F. (author)
- Karolinska Institute,Karolinska Inst, Sweden
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- Gustafsson, A. L. (author)
- Children Clinic, Halland's Hospital, Halmstad, Sweden,Halmstad County Hospital,Hallands Hosp, Sweden
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- Arvidsson, C. G. (author)
- Department of Pediatrics, Västmanland's Hospital, Västerås, Sweden,Vastmanlands Hosp, Sweden
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- Fureman, A. L. (author)
- Children's clinic, Östersund Hospital, Sweden,Ostersund Hosp, Sweden
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- Forsander, Gun, 1951 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden
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- Elding Larsson, Helena (author)
- Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden
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- Särnblad, Stefan, 1963- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Lindgren, Marie (author)
- Lund University,Lunds universitet,Pediatrisk autoimmunitet,Forskargrupper vid Lunds universitet,Pediatric Autoimmunity,Lund University Research Groups,Skåne University Hospital,Vrinnevi Hospital,Region Östergötland, Barn- och ungdomskliniken i Norrköping,Lund Univ, Sweden
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- Ludvigsson, Johnny, 1943- (author)
- Linköpings universitet,Linköping University,Linköping University Hospital,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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Marcus, C. (author)
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- Lycka, A. P. (author)
- Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden
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- Persson, M. (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden
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- Samuelsson, Ulf, 1951- (author)
- Linköpings universitet,Linköping University,Linköping University Hospital,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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Sarnblad, S. (author)
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- Åkesson, Karin (author)
- Jönköping University,The Jönköping Academy for Improvement of Health and Welfare,Department of Pediatrics, Ryhov County Hospital, Jönköping, Sweden,Ryhov Cty Hosp, Sweden; Jonkoping Univ, Sweden
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- Oortqvist, E. (author)
- Karolinska Institute,Karolinska Inst, Sweden
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- Ivarsson, Sten A. (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital,Pediatrisk autoimmunitet,Pediatric Autoimmunity,Lund Univ, Sweden
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(creator_code:org_t)
- 2020-12-12
- 2021
- English.
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In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 22:3, s. 417-424
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Abstract
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- Objectives Children with type 1 diabetes (T1D) are not included in guidelines regarding diagnosis criteria for celiac disease (CD) without a diagnostic biopsy, due to lack of data. We explored whether tissue transglutaminase antibodies (anti-tTG) that were >= 10 times the upper limit of normal (10x ULN) predicted CD in T1D. Methods Data from the Swedish prospective Better Diabetes Diagnosis study was used, and 2035 children and adolescents with T1D diagnosed between 2005-2010 were included. Of these, 32 had been diagnosed with CD before T1D. The children without CD were repeatedly screened for CD using anti-tTG antibodies of immunoglobulin type A. In addition, their human leukocyte antigen (HLA) were genotyped. All children with positive anti-tTG were advised to undergo biopsy. Biopsies were performed on 119 children and graded using the Marsh-Oberhuber classification. Results All of the 60 children with anti-tTG >= 10x ULN had CD verified by biopsies. The degree of mucosal damage correlated with anti-tTG levels. Among 2003 screened children, 6.9% had positive anti-tTG and 5.6% were confirmed CD. The overall CD prevalence, when including the 32 children with CD before T1D, was 7.0% (145/2035). All but one of the children diagnosed with CD had HLA-DQ2 and/or DQ8. Conclusions As all screened children and adolescents with T1D with tissue transglutaminase antibodies above 10 times the positive value 10x ULN had CD, we propose that the guidelines for diagnosing CD in screened children, when biopsies can be omitted, should also apply to children and adolescents with T1D as a noninvasive method.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- biopsy
- celiac disease
- screening
- tissue transglutaminase antibodies
- type 1 diabetes
- diagnosis
- prevalence
- risk
- guidelines
- biopsies
- serology
- cohort
- diet
- Endocrinology & Metabolism
- Pediatrics
- Celiac disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bybrant, M. C.
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Uden, E.
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Frederiksen, F.
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Gustafsson, A. L ...
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Arvidsson, C. G.
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Fureman, A. L.
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show more...
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Forsander, Gun, ...
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Elding Larsson, ...
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Särnblad, Stefan ...
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Lindgren, Marie
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Ludvigsson, John ...
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Marcus, C.
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Lycka, A. P.
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Persson, M.
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Samuelsson, Ulf, ...
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Sarnblad, S.
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Åkesson, Karin
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Oortqvist, E.
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Ivarsson, Sten A ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nursing
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Pediatric Diabet ...
- By the university
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University of Gothenburg
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Örebro University
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Jönköping University
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Lund University
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Karolinska Institutet
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Linköping University