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1.
  • Davies, G., et al. (författare)
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
  • 2018
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
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2.
  • Schlüter, Maja, et al. (författare)
  • A framework for mapping and comparing behavioural theories in models of social-ecological systems
  • 2017
  • Ingår i: Ecological Economics. - : Elsevier BV. - 0921-8009 .- 1873-6106. ; 131, s. 21-35
  • Tidskriftsartikel (refereegranskat)abstract
    • Formal models are commonly used in natural resource management (NRM) to study human-environment interactions and inform policy making. In the majority of applications, human behaviour is represented by the rational actor model despite growing empirical evidence of its shortcomings in NRM contexts. While the importance of accounting for the complexity of human behaviour is increasingly recognized, its integration into formal models remains a major challenge. The challenges are multiple: i) there exist many theories scattered across the social sciences, ii) most theories cover only a certain aspect of decision-making, iii) they vary in their degree of formalization, iv) causal mechanisms are often not specified. We provide a framework- MoHuB (Modelling Human Behavior) - to facilitate a broader inclusion of theories on human decision-making in formal NRM models. It serves as a tool and common language to describe, compare and communicate alternative theories. In doing so, we not only enhance understanding of commonalities and differences between theories, but take a first step towards tackling the challenges mentioned above. This approach may enable modellers to find and formalize relevant theories, and be more explicit and inclusive about theories of human decision making in the analysis of social ecological systems.
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