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Increased levels of...
Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from patients with aspirin-intolerant asthma
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Gaber, Flora (författare)
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Daham, K (författare)
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Higashi, A (författare)
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visa fler...
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Higashi, N (författare)
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Gülich, A (författare)
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- Delin, Ingrid (författare)
- Karolinska Institutet
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- James, A (författare)
- Karolinska Institutet
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- Skedinger, M (författare)
- Karolinska Institutet
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Gyllfors, Per (författare)
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- Nord, M (författare)
- Karolinska Institutet
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- Dahlén, Sven-Erik (författare)
- Karolinska Institutet
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- Kumlin, Maria (författare)
- Sophiahemmet Högskola
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- Dahlén, B (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-05-20
- 2008
- Engelska.
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Ingår i: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 63:12, s. 1076-82
- Relaterad länk:
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https://thorax.bmj.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- BACKGROUND: A diagnosis of aspirin-intolerant asthma requires aspirin provocation in specialist clinics. Urinary leukotriene E(4) (LTE(4)) is increased in aspirin-intolerant asthma. A study was undertaken to investigate new biomarkers of aspirin intolerance by comparing basal levels of cysteinyl-leukotrienes (CysLTs) and leukotriene B(4) (LTB(4)) in saliva, sputum and ex vivo stimulated blood in subjects with aspirin-intolerant and aspirin-tolerant asthma. The effects of aspirin- and allergen-induced bronchoconstriction on leukotriene levels in saliva and ex vivo stimulated blood were also compared with the effects of the provocations on urinary mediators. METHODS: Induced sputum, saliva, urine and blood were obtained at baseline from 21 subjects with asthma. At a separate visit, 11 subjects showed a positive response to lysine-aspirin inhalation and 10 were aspirin tolerant. Saliva, blood and urine were also collected on the provocation day. Analyses of CysLTs and LTB(4) and the prostaglandin D(2) metabolite 9alpha,11beta-prostaglandin F(2) were performed and the fraction of exhaled nitric oxide was measured. RESULTS: Subjects with aspirin-intolerant asthma had higher exhaled nitric oxide levels and higher baseline levels of CysLTs in saliva, sputum, blood ex vivo and urine than subjects with aspirin-tolerant asthma. There were no differences in LTB(4) levels between the groups. Levels of urinary LTE(4) and 9alpha,11beta-prostaglandin F(2) increased after aspirin provocation whereas leukotriene levels in saliva and ex vivo stimulated blood did not increase. CONCLUSION: These findings support a global and specific increase in CysLT production in aspirin-intolerant asthma. Measurement of CysLTs in saliva has the potential to be a new and convenient non-invasive biomarker of aspirin-intolerant asthma.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Thorax
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Till lärosätets databas
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Gaber, Flora
-
Daham, K
-
Higashi, A
-
Higashi, N
-
Gülich, A
-
Delin, Ingrid
-
visa fler...
-
James, A
-
Skedinger, M
-
Gyllfors, Per
-
Nord, M
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Dahlén, Sven-Eri ...
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Kumlin, Maria
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Dahlén, B
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visa färre...
- Artiklar i publikationen
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Thorax
- Av lärosätet
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Sophiahemmet Högskola
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Karolinska Institutet