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Sökning: WFRF:(James Stefan) > RISE

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1.
  • Nord, Stefan, et al. (författare)
  • NPAD - Final Report D1.3 : Network-RTK Positioning for Automated Driving
  • 2021
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • Future automated vehicles and advanced driver assistance systems are highly dependent on sensors to detect their environment as well as robust, accurate, and cost-effective sensor systems for positioning. Global Navigation Satellite systems (GNSS) provide a key technology that enables an absolute position estimate and Network-RTK (Real Time Kinematic) has the potential to meet the requirements of cost, accuracy, and availability. This technology is based on correction data being received from a fixed reference station via e.g. mobile communication. Current implementations have been driven by requirements from applications which operate within a limited region for lengthy periods of time, such as surveying and precision agriculture. These applications can tolerate relatively long initialization times and can afford expensive equipment.The mass market wants to benefit from infrastructure in place for these applications, but the requirements are somewhat different. Problems occur when the device moves from the coverage area of one reference station to another and reinitialization must be made. Consumer devices must also deliver similar performance with inexpensive components. In addition to this, the existing public-sector system for distribution of correction data, in Sweden governed by Lantmäteriet/ SWEPOS, is not designed for handling a large number of clients and efficiently distributing correction data to these clients based on their location.The telecom industry in 3GPP (Third generation partnership project) is currently addressing the need for a scalable provisioning of network RTK corrections. Based on the 3GPP specification, the project aimed to develop, implement, test and demonstrate an efficient distribution system for Network-RTK correction data in order to enable cm-level accuracy GNSS positioning for a large number of mobile platforms e.g. automated vehicles.The NPAD project has:Leveraged the existing Lantmäteriet/SWEPOS GNSS reference infrastructure to implement a virtual network of reference stations that provided coverage over selected test areas suitable for supporting a large number of simultaneous users.Implemented a scalable GNSS correction data provisioning based on the ongoing work in 3GPP that provides correction data from the reference network to mobile devices;Developed test cases for automated vehicle platforms related to positioning and implemented demonstrators;Investigated tools and methods for validating the accuracy of integrated GNSS positioning and navigation systems.The project was coordinated by RISE Research Institutes of Sweden and involved besides Lantmäteriet and AstaZero the following industrial partners: AB Volvo, Caliterra, Einride, Ericsson, Scania, and Waysure.
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2.
  • Scott, James S., et al. (författare)
  • Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists
  • 2014
  • Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society. - 0022-2623 .- 1520-4804. ; 57:21, s. 8984-8998
  • Tidskriftsartikel (refereegranskat)abstract
    • Agonism of GPR119 is viewed as a potential therapeutic approach for the treatment of type II diabetes and other elements of metabolic syndrome. During progression of a previously disclosed candidate 1 through mice toxicity studies, we observed tonic-clonic convulsions in several mice at high doses. An in vitro hippocampal brain slice assay was used to assess the seizure liability of subsequent compounds, leading to the identification of an aryl sulfone as a replacement for the 3-cyano pyridyl group. Subsequent optimization to improve the overall profile, specifically with regard to hERG activity, led to alkyl sulfone 16. This compound did not cause tonic-clonic convulsions in mice, had a good pharmacokinetic profile, and displayed in vivo efficacy in murine models. Importantly, it was shown to be effective in wild-type (WT) but not GPR119 knockout (KO) animals, consistent with the pharmacology observed being due to agonism of GPR119.
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