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Sökning: WFRF:(Janson Eva T)

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  • Fjällskog, Marie-Louise, et al. (författare)
  • Expression of somatostatin receptor subtypes 1 to 5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors
  • 2003
  • Ingår i: Medical Oncology. - 1357-0560 .- 1559-131X. ; 20:1, s. 59-67
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Somatostatin analogs are well established in the treatment of malignant endocrine pancreatic tumors (EPTs). Our goal is to individualize their treatment using receptor-subtype-specific analogs and, therefore, exploring the receptor expression is highly important. We have examined the expression of somatostatin receptor (sst) subtypes 1–5 on tumor cells and in intratumoral vessels in 28 tumor tissues from malignant EPTs with immunohistochemistry using sst-subtype-specific polyclonal antibodies. We found that sst<sub>2</sub> and sst<sub>4</sub> stained positive in 90% and sst<sub>1</sub> in 70% of the tumor tissues, whereas sst<sub>3</sub> and sst<sub>5</sub> stained positive in only 50% of the tumor tissues. Sst expression in intratumoral vessels was high for sst<sub>2</sub> and sst<sub>4</sub> (80%), moderate for sst<sub>1</sub> (40%), and low for sst<sub>3</sub> and sst<sub>5</sub> (10%). The ssts were evenly distributed among the different tumor subtypes. However, tumors belonging to the same subgroup of EPTs showed a variable expression of receptor subtypes. No differences in receptor-subtype expression could be seen between poorly and well-differentiated tumors, nor between primary tumors and metastases. Prior medical treatment did not influence sst expression pattern. In conclusion, sst<sub>2</sub> and sst<sub>4</sub> were expressed in most tumor tissues and intratumoral vessels from EPTs. However, sst<sub>3</sub> and sst<sub>5</sub> were lacking in half of the tumor tissues and in most of the intratumoral vessels. These differences indicate the importance of determining each tumor’s subset of receptors before treatment with receptor-subtype-specific analogs is initiated. The importance of sst expression in intratumoral vessels is not yet known.</p>
  • Kuhry, E., et al. (författare)
  • Impact of hospital case volume on short-term outcome after laparoscopic operation for colonic cancer
  • 2005
  • Ingår i: Surgical endoscopy. - 1432-2218. ; 19:5, s. 687-692
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: High hospital case volume has been associated with improved outcome after open operation for colorectal malignancies. METHODS: To assess the impact of hospital case volume on short-term outcome after laparoscopic operation for colon cancer, we conducted an analysis of patients who underwent laparoscopic colon resection within the COlon Cancer Laparoscopic or Open Resection (COLOR) trial. RESULTS: A total of 536 patients with adenocarcinoma of the colon were included in the analysis. Median operating time was 240, 210 and 188 min in centers with low, medium, and high case volumes, respectively (p < 0.001). A significant difference in conversion rate was observed among low, medium, and high case volume hospitals (24% vs 24% vs 9%; p < 0.001). A higher number of lymph nodes were harvested at high case volume hospitals (p < 0.001). After operation, fewer complications (p = 0.006) and a shorter hospital stay (p < 0.001) were observed in patients treated at hospitals with high caseloads. CONCLUSIONS: Laparoscopic operation for colon cancer at hospitals with high caseloads appears to be associated with improved short-term results.
  • Ludvigsen, Eva, et al. (författare)
  • Altered Expression of Somatostatin Receptors in Pancreatic Islets from NOD Mice Cultured at Different Glucose Concentrations In Vitro and in Islets Transplanted to Diabetic NOD Mice In Vivo
  • 2011
  • Ingår i: Experimental Diabetes Research. - 1687-5214 .- 1687-5303. ; 2011, s. 623472
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Somatostatin acts via five receptors (sst<sub>1-5</sub>). We investigated if the changes in pancreatic islet sst expression in diabetic NOD mice compared to normoglycemic mice are a consequence of hyperglycemia or the ongoing immune reaction in the pancreas. Pancreatic islets were isolated from NOD mice precultured for 5 days and further cultured for 3 days at high or low glucose before examined. Islets were also isolated from NOD mice and transplanted to normal or diabetic mice in a number not sufficient to cure hyperglycemia. After three days, the transplants were removed and stained for sst<sub>1-5</sub> and islet hormones. Overall, changes in sst islet cell expression were more common in islets cultured in high glucose concentration <em>in vitro</em> as compared to the islet transplantation <em>in vivo</em> to diabetic mice. The beta and PP cells exhibited more frequent changes in sst expression, while the alpha and delta cells were relatively unaffected by the high glucose condition. Our findings suggest that the glucose level may alter sst expressed in islets cells; however, immune mechanisms may counteract such changes in islet sst expression.</p>
  • Walsh, Kyle M., et al. (författare)
  • A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum
  • 2011
  • Ingår i: Endocrine-Related Cancer. - 1351-0088 .- 1479-6821. ; 18:1, s. 171-180
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Genetic studies of midgut carcinoid cancer have exclusively focused on genomic changes of the tumor cells. We investigated the role of constitutional genetic polymorphisms in predisposing individuals to ileal carcinoids. In all, 239 cases and 110 controls were collected from three institutions: the Uppsala University Hospital; the Dana-Farber Cancer Institute; and the MD Anderson Cancer Center, and were genotyped using microarrays assaying &gt;300 000 single nucleotide polymorphisms. Association with rs2208059 in <em>KIF16B</em> approached statistical significance (Mantel-Haenszel odds ratio=2.42, <em>P</em>=4.16×10<sup>−7</sup>) at a Bonferroni-corrected level (&lt;1.62×10<sup>−7</sup>). Using two computational algorithms, four copy-number variants (CNVs) were identified in multiple cases that were absent in study controls and markedly less frequent in ∼1500 population-based controls. Of these four constitutional CNVs identified in blood-derived DNA, a 40 kb heterozygous deletion in Chr18q22.1 corresponded with a region frequently showing loss of heterozygosity (LOH) in ileal carcinoid tumor cells based on our meta-analysis of previously published cytogenetic studies (69.7% LOH, 95% confidence interval=60.0–77.9%). We analyzed the constitutional 40 kb deletion on chr18 in our study samples with a real-time quantitative PCR assay; 14/226 cases (6.19%) and 2/97 controls (2.06%) carried the CNV, although the exact boundaries of each deletion have not been determined. Given the small sample size, our findings warrant an independent cohort for a replication study. Owing to the rarity of this disease, we believe these results will provide a valuable resource for future work on this serious condition by allowing others to make efficient use of their samples in targeted studies.</p>
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