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- Malmstrom, Vivianne, et al.
(författare)
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T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
- 2000
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Ingår i: Arthritis Research. - : Springer Science and Business Media LLC. - 1465-9905. ; 2:4, s. 315-326
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Tidskriftsartikel (refereegranskat)abstract
- The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as IFN-gamma secretion and ability to provide B cell help. These mice were still susceptible to CIA. The response was mainly directed to the glycosylated form of the CII 256-270 peptide, rather than to the nonglycosylated peptide. Tolerance induction was rapid; transferred T cells encountered CII within a few days. CII immunization several weeks after thymectomy of the mice did not change their susceptibility to arthritis or the induction of partial T-cell tolerance, excluding a role for recent thymic emigrants. Thus, partially tolerant CII autoreactive T cells are maintained and are crucial for the development of CIA.
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