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Sprint exercise enh...
Sprint exercise enhances skeletal muscle p70S6k phosphorylation and more so in women than in men.
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- Esbjörnsson, M (författare)
- Karolinska Institutet,Inst. för laboratoriemedicin
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- Rundqvist, H C (författare)
- Karolinska Institutet,Inst. för laboratoriemedicin
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- Mascher, H (författare)
- Karolinska Institutet,CLINTEC
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- Österlund, T (författare)
- Karolinska Institutet,Inst. för laboratoriemedicin
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- Rooyackers, O (författare)
- Karolinska Institutet,CLINTEC
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- Blomstrand, Eva (författare)
- Gymnastik- och idrottshögskolan,Eva Blomstrands forskningsgrupp
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- Jansson, E (författare)
- Karolinska Institutet,Inst. för laboratoriemedicin
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Karolinska Institutet Inst för laboratoriemedicin (creator_code:org_t)
- 2012-01-23
- 2012
- Engelska.
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Ingår i: Acta Physiologica. - : Wiley. - 1748-1708 .- 1748-1716. ; 205:3, s. 411-22
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- AIM: Sprint exercise is characterized by repeated sessions of brief intermittent exercise at a high relative workload. However, little is known about the effect on mTOR pathway, an important link in the regulation of muscle protein synthesis. An earlier training study showed a greater increase in muscle fibre cross-sectional area in women than men. Therefore, we tested the hypothesis that the activation of mTOR signalling is more pronounced in women than in men. Healthy men (n=9) and women (n=8) performed three bouts of 30-s sprint exercise with 20-min rest in between.METHODS: Multiple blood samples were collected over time, and muscle biopsy specimens were obtained at rest and 140 min after the last sprint.RESULTS: Serum insulin increased by sprint exercise and more so in women than in men [gender (g) × time (t)]: P=0.04. In skeletal muscle, phosphorylation of Akt increased by 50% (t, P=0.001) and mTOR by 120% (t, P=0.002) independent of gender. The elevation in p70S6k phosphorylation was larger in women (g × t, P=0.03) and averaged 230% (P=0.006) as compared to 60% in men (P=0.04). Phosphorylation rpS6 increased by 660% over time independent of gender (t, P=0.003). Increase in the phosphorylation of p70S6k was directly related to increase in serum insulin (r=0.68, P=0.004).CONCLUSION: It is concluded that repeated 30-s all-out bouts of sprint exercise separated by 20 min of rest increases Akt/mTOR signalling in skeletal muscle. Secondly, signalling downstream of mTOR was stronger in women than in men after sprint exercise indicated by the increased phosphorylation of p70S6k.
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- Medicin/Teknik
- Medicine/Technology
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