| 1. |
- Meuller, Bengt, et al.
(författare)
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Review of Spark Discharge Generators for Production of Nanoparticle Aerosols
- 2012
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Ingår i: Aerosol Science and Technology. - : Informa UK Limited. - 1521-7388 .- 0278-6826. ; 46:11, s. 1256-1270
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Forskningsöversikt (refereegranskat)abstract
- In the growing field of nanotechnology there is an increasing need to develop production methods for nanoparticles, especially methods that provide control and reproducibility. The spark discharge generator (SDG) is a versatile device for the production of nanoparticle aerosols. It can produce aerosol nanoparticles in the entire nanometer range (1-100 nm), and beyond. Depending on requirements, and the system used, these nanoparticles can be completely contamination free and composed of one or more materials. This provides a unique opportunity to create new materials on the nanoscale. Already in use in semiconductor, materials, health and environmental research, the SDG shows promise for yet more applications. If needed, particle production by the SDG could be scaled up using parallel generators facilitating continuous high-volume production of aerosol nanoparticles. Still, there is a surprisingly low knowledge of fundamental processes in the SDG. In this article we present a thorough review of the most common and relevant SDGs and the theory of their operation. Some possible improvements are also discussed.
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| 2. |
- Bollati, Michela, et al.
(författare)
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Structure and functionality in flavivirus NS-proteins : perspectives for drug design
- 2010
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Ingår i: Antiviral Research. - : Elsevier BV. - 0166-3542 .- 1872-9096. ; 87:2, s. 125-148
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Forskningsöversikt (refereegranskat)abstract
- Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of virology, members of the Flavivirus genus, such as West Nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. Additional environmental and demographic considerations suggest that novel or known flaviviruses will continue to emerge in the future. Nevertheless, up to few years ago flaviviruses were considered low interest candidates for drug design. At the start of the European Union VIZIER Project, in 2004, just two crystal structures of protein domains from the flaviviral replication machinery were known. Such pioneering studies, however, indicated the flaviviral replication complex as a promising target for the development of antiviral compounds. Here we review structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex. Most of the reviewed results were achieved within the European Union VIZIER Project, and cover topics that span from viral genomics to structural biology and inhibition mechanisms. The ultimate aim of the reported approaches is to shed light on the design and development of antiviral drug leads.
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| 3. |
- Dreja, Karl, et al.
(författare)
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Njursjukdomar
- 2016
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Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 457-482
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Bokkapitel (populärvet., debatt m.m.)
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| 4. |
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| 5. |
- Drevenhorn, Eva, et al.
(författare)
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Risk för ohälsa
- 2016
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Ingår i: Omvårdnad och medicin. - : Studentlitteratur AB. - 9789144076645 ; , s. 73-92
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
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| 6. |
- Gagnemo Persson, Rebecca, et al.
(författare)
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Lungsjukdomar
- 2016. - 1
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Ingår i: Omvårdnad och medicin. - 9789144076645 ; , s. 281-311
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Bokkapitel (populärvet., debatt m.m.)
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| 7. |
- Gagnemo Persson, Rebecca, et al.
(författare)
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Läkemedel
- 2016. - 1
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Ingår i: Omvårdnad & medicin. - 9789144076645 ; , s. 125-138
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Bokkapitel (populärvet., debatt m.m.)
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| 8. |
- Göransson, Katarina, 1974-, et al.
(författare)
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Triage på akutmottagning
- 2008. - 1
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Bok (refereegranskat)abstract
- Boken beskriver akutmottagningstriage i detalj; organisationen kring triage och skalor för att gradera patientens medicinska angelägenhetsgrad belyses ur ett internationellt och svenskt perspektiv. Boken tar även upp medicinska aspekter vid akutmottagningstriage; bedömningen av de nyanlända patienterna och hur dessa bör övervakas och utvärderas under vårdtillfället. Organisatoriska aspekter kring akutmottagningstriage som ansvarsfördelning, effekter av triage och utveckling av en triageenhet belyses. Dokumentation kring akutmottagningssjukvård i allmänhet och triage i synnerhet uppmärksammas, liksom omvårdnad vid t.ex. smärta och fallrisk.Boken vänder sig i första hand till sjuksköterskor verksamma på akutmottagningar och inom prehospital verksamhet. Som den första svenska boken i ämnet kan den vara till glädje för övriga yrkesgrupper inom akutsjukvården, för beslutsfattare och för studenter som vill öka sina kunskaper om triage.
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| 9. |
- Jansson, Anna M
(författare)
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Inflammatory markers and prognosis in acute coronary syndromes
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Inflammation both accelerates atherosclerosis and contributes to the activation and rupture of the atherosclerotic plaque. Several markers of inflammation, such as CRP, have shown prognostic merit in patients with acute coronary syndromes (ACS). Aims: To investigate the association between circulating levels of some markers with relation to inflammation – osteoprotegerin (OPG), Chemokine (C-X-C motif) ligand 16 (CXCL16) and chromogranin A (CgA) – and prognosis in a population of patients with ACS. Material and methods: Patients aged 18-79 years who were admitted to the coronary care unit at a university hospital with an ACS had blood drawn within 24 hours and after 3 months; echocardiography with determination of the left ventricular ejection fraction (LVEF) was performed within 5 days of admission. Mortality data were obtained from the Swedish National Population Registry and morbidity data from the Swedish Hospital Discharge Registry. The length of follow-up was a median of 81-92 months. Results: Higher OPG levels were associated with an increased likelihood of ST-elevation myocardial infarction (MI), markers of myocardial damage and indices of cardiac dysfunction such as LVEF and B-type natriuretic peptide (BNP). The patients with the higher levels were also more likely to have a history of heart failure (HF) and to be hypotensive on arrival. The circulating OPG levels were predictive of long-term mortality and the incidence of rehospitalization due to HF, a relationship that remained significant after adjustment for clinical risk factors and, in a subgroup where such data were available, after further adjustment for LVEF, CRP, BNP and troponin. The C-statistics of the prognostic information offered by OPG were significantly better than CRP and troponin and similar to BNP and LVEF. For CXCL16, as for OPG, higher levels were associated with higher age and STEMI. CXCL16 predicted long-term mortality, future hospitalizations for HF and new MI, also after adjustment for clinical risk factors. After further adjustments for LVEF, CRP, proBNP and troponin, only the combination of OPG and CXCL16 serum levels predicted cardiovascular (CV) and all-cause mortality, as well as HF rehospitalizations. This was true for both the long term and short term, even after adjustment for the Global Registry of Acute Coronary Events (GRACE) score. Serum levels of OPG and CXCL16 at day 1 and 3 months after ACS were similarly associated with outcome. CgA was also an independent predictor of mortality and HF after adjustments for conventional risk factors, including troponin, and was still significantly associated with mortality after further adjustment for LVEF and proBNP. Conclusions: Even after adjustment for conventional risk markers, serum levels of OPG, CXCL16 and CgA were predictive of long-term mortality and rehospitalizations due to HF in patients with ACS. We also found that a combination of OPG and CXCL16 serum levels was predictive of mortality and HF hospitalizations - and gave more information than each marker alone - in both the long term and the short term, even after adjustment for the GRACE score. Inflammatory markers appear to add prognostic value above and beyond clinical information.
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| 10. |
- Jansson, Anna M, et al.
(författare)
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Prognostic value of circulating chromogranin A levels in acute coronary syndromes.
- 2009
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Ingår i: European heart journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 30:1, s. 25-32
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Tidskriftsartikel (refereegranskat)abstract
- To determine whether circulating levels of chromogranin A (CgA) provide prognostic information independently of conventional risk markers in acute coronary syndromes (ACSs).
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