SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Jaworska K) ;lar1:(gu)"

Sökning: WFRF:(Jaworska K) > Göteborgs universitet

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Jones, Benedict C, et al. (författare)
  • To which world regions does the valence-dominance model of social perception apply?
  • 2021
  • Ingår i: Nature Human Behaviour. - : Springer Science and Business Media LLC. - 2397-3374. ; 5:1, s. 159-169
  • Tidskriftsartikel (refereegranskat)abstract
    • Over the past 10 years, Oosterhof and Todorov's valence-dominance model has emerged as the most prominent account of how people evaluate faces on social dimensions. In this model, two dimensions (valence and dominance) underpin social judgements of faces. Because this model has primarily been developed and tested in Western regions, it is unclear whether these findings apply to other regions. We addressed this question by replicating Oosterhof and Todorov's methodology across 11 world regions, 41 countries and 11,570 participants. When we used Oosterhof and Todorov's original analysis strategy, the valence-dominance model generalized across regions. When we used an alternative methodology to allow for correlated dimensions, we observed much less generalization. Collectively, these results suggest that, while the valence-dominance model generalizes very well across regions when dimensions are forced to be orthogonal, regional differences are revealed when we use different extraction methods and correlate and rotate the dimension reduction solution. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 5 November 2018. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.7611443.v1 .
  •  
2.
  • Maxwell, Christopher A., et al. (författare)
  • Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer
  • 2011
  • Ingår i: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885 .- 1544-9173. ; 9:11
  • Tidskriftsartikel (refereegranskat)abstract
    • Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Nevanlinna, Heli (1)
Hatami, Javad (1)
Aczel, Balazs (1)
Cybulski, Cezary (1)
John, Esther M (1)
Guigo, Roderic (1)
visa fler...
Karlsson, Per, 1963 (1)
Vidal, Marc (1)
Gruber, Stephen B. (1)
Moreno, Victor (1)
Rennert, Gad (1)
Capella, Gabriel (1)
Aguilar, Helena (1)
Urruticoechea, Ander (1)
Serra-Musach, Jordi (1)
Bonifaci, Núria (1)
Brunet, Joan (1)
Martrat, Griselda (1)
Gómez-Baldó, Laia (1)
Villanueva, Alberto (1)
Benitez, Javier (1)
Bonanni, Bernardo (1)
Chenevix-Trench, Geo ... (1)
Collee, J. Margriet (1)
Daly, Mary B. (1)
Devilee, Peter (1)
Evans, D. Gareth (1)
Hamann, Ute (1)
Jakubowska, Anna (1)
Meindl, Alfons (1)
Offit, Kenneth (1)
Radice, Paolo (1)
Schmutzler, Rita K. (1)
Couch, Fergus J. (1)
Easton, Douglas F. (1)
Ask, Karl, 1978 (1)
Chartier, Christophe ... (1)
Christopherson, Cody ... (1)
Levitan, Carmel A. (1)
Miller, Jeremy K. (1)
Schmidt, Kathleen (1)
Stieger, Stefan (1)
Vanpaemel, Wolf (1)
Vianello, Michelange ... (1)
Voracek, Martin (1)
Ehrencrona, Hans (1)
Schmitt, Michael (1)
Olofsson, Jonas K. (1)
Liuzza, Marco Tullio (1)
Loman, Niklas (1)
visa färre...
Lärosäte
Göteborgs universitet  (2)Ta bort avgränsningen
Uppsala universitet (1)
Stockholms universitet (1)
Högskolan Väst (1)
Lunds universitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (1)
Medicin och hälsovetenskap (1)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy