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Alkylresorcinols (b...
Alkylresorcinols (biomarkers of whole grain intake), cereal fibre intake and metabolic profile - results from a European study
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- Kyro, Cecilie (författare)
- Danish Cancer Research Society Center, Denmark
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- Biskup, Izabela, 1984 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Brunius, Carl, 1974 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Thomsen, Birthe Lykke Riegels (författare)
- Danish Cancer Research Society Center, Denmark
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- Romieu, Isabelle (författare)
- International Agency for Research on Cancer (IARC)
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer (IARC)
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- Eriksen, Anne Kirstine (författare)
- Danish Cancer Research Society Center, Denmark
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- Bueno-de-Mesquita, Bas (författare)
- Imperial College of Science, Technology and Medicine
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- Riboli, Elio (författare)
- Imperial College of Science, Technology and Medicine
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- Lu, Yunxia (författare)
- Imperial College of Science, Technology and Medicine,University of California at Irvine (UCI)
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer (IARC)
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- Aleksandrova, Krasimira (författare)
- Netherlands National Institute for Public Health & the Environment,Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE),German Institute of Human Nutrition Potsdam-Rehbrucke (DIfE)
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- Tjonnelandl, Anne (författare)
- Danish Cancer Research Society Center, Denmark
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- Olsen, Anja (författare)
- Danish Cancer Research Society Center, Denmark
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- Landberg, Rikard (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- Cambridge University Press, 2020
- 2020
- Engelska.
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Ingår i: Proceedings of the Nutrition Society. - : Cambridge University Press. - 0029-6651 .- 1475-2719. ; 79:OCE2, s. E648-E648
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: High intakes of whole-grains and cereal fiber have been consistently associated with lower risk of cardiometabolic diseases in observational studies. Yet, improved understanding about the underlying mechanisms is needed. We hypothesized that cereal fiber and whole-grain are associated with beneficial metabolic marker profiles.Aim: To investigate if cereal fiber intake, estimated by food frequency questionnaires and plasma total alkylresorcinols concentrations as well as the C17:0/C21:0-ratio in plasma as biomarkers of whole-grain wheat and rye intake or the relative whole-grain rye to wheat intake, respectively, were associated with metabolic biomarkers.Design: A cross-sectional study conducted to investigate the associations between alkylresorcinols as biomarker of whole-grain wheat and rye intake, cereal fiber and selected metabolic biomarkers among 954 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cereal fiber intake was assessed by FFQ and whole grain wheat and rye were reflected by biomarkers analyzed in plasma samples, i.e. total alkylresorcinol (AR). Moreover, the ratio of two of the five measured alkylresorcinols (AR C17:0/C21:0 ratio) was used as an indicator of whole-grain source (wheat or rye). Metabolic biomarkers (HbA1c, C-peptide, IGFBP-1, IGFBP-2, total cholesterol, LDL, HDL, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B (ApoB) and CRP) were measured in blood samples. All biomarkers were already measured for nested case-control studies of colorectal cancer matched based on sex, study center, age at blood collection, date and time of blood collection, fasting status. Women were further matched by menopausal status, phase of menstrual cycle, and use of oral contraceptives or hormone replacement therapy at time of blood collection. Multivariable linear regression analysis was used to investigate the relationship between exposure variables metabolic biomarkers adjusted for case-control status and common confounders.Results: No associations were found between cereal fiber intake and the metabolic markers. However, whole-grain wheat and rye intake, reflected by total AR, was associated with a lower concentration of the inflammation marker CRP. The alkylresorcinol C17:0/C21:0 ratio was not associated with any of the measured metabolic markers in this cohort.Conclusion: Overall, we found no support for an association between cereal fibre intake, whole grain wheat and rye intake reflected by biomarkers and metabolic markers in the present cohort. One exception was the finding of an inverse association between whole grain biomarkers and CRP. Prospective studies or RCTs are warranted to confirm our findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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Kyro, Cecilie
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Biskup, Izabela, ...
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Brunius, Carl, 1 ...
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Thomsen, Birthe ...
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Romieu, Isabelle
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Jenab, Mazda
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Eriksen, Anne Ki ...
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Bueno-de-Mesquit ...
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Riboli, Elio
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Lu, Yunxia
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Weiderpass, Elis ...
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Aleksandrova, Kr ...
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Tjonnelandl, Ann ...
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Olsen, Anja
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Landberg, Rikard
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Umeå universitet
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Chalmers tekniska högskola