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1.
  • Jiang, Xia, et al. (författare)
  • Shared heritability and functional enrichment across six solid cancers
  • 2019
  • Ingår i: Nature Communications. - 2041-1723. ; 10
  • Tidskriftsartikel (refereegranskat)abstract
    • Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. © 2019, The Author(s).
2.
  • Abazov, V. M., et al. (författare)
  • Limits on anomalous trilinear gauge couplings from WW -> e(+)e(-), WW -> e(+/-)mu(-/+), and WW ->mu(+)mu(-) events from pp collisions at root s=1.96 TeV
  • 2006
  • Ingår i: Physical Review D - Particles, Fields, Gravitation and Cosmology. - 1550-7998. ; 74:5, s. 057101
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Limits are set on anomalous WW gamma and WWZ trilinear gauge couplings using W+W--&gt; e(+)nu(e)e(-)(nu) over bar (e), W+W--&gt; e(+/-)nu(e)mu(-/+)nu(mu), and W+W--&gt;mu(+)nu(mu)mu(-)(nu) over bar (mu) events. The data set was collected by the Run II D0 detector at the Fermilab Tevatron Collider and corresponds to approximately 250 pb(-1) of integrated luminosity at root s=1.96 TeV. Under the assumption that the WW gamma couplings are equal to the WWZ couplings and using a form factor scale of Lambda=2.0 TeV, the combined 95% C.L. one-dimensional coupling limits from all three channels are -0.32 &lt;Delta kappa &lt; 0.45 and -0.29 &lt;lambda &lt; 0.30.</p>
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3.
  • Abazov, V. M., et al. (författare)
  • Measurement of beta (t -&gt; Wb)/beta(t -&gt; Wq) at root s=1.96 TeV
  • 2006
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 639:6, s. 616-622
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present the measurement of R = B(t -&gt; Wb)/B(t -&gt; Wq) in pp collisions at root s = 1.96 TeV, using 230 pb(-1) of data collected by the DO experiment at the Fermilab Tevatron Collider. We fit simultaneously R and the number (N-tt) of selected top quark pairs (tt), to the number of identified b-quark jets in events with one electron or one muon, three or more jets, and high transverse energy imbalance. To improve sensitivity, kinematical properties of events with no identified b-quark jets are included in the fit. We measure R = 1.03(-0.17)(0.19) (stat + syst), in good agreement with the standard model. We set lower limits of R &gt; 0.61 and vertical bar V-tb vertical bar &gt; 0.78 at 95% confidence level.</p>
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4.
  • Abazov, V. M., et al. (författare)
  • Measurement of the B-s(0) lifetime using semileptonic decays
  • 2006
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:24, s. 241801
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We report a measurement of the B-s(0) lifetime in the semileptonic decay channel B-s(0)-&gt; D-s(-)mu(+)nu X (and its charge conjugate), using approximately 0.4 fb(-1) of data collected with the D0 detector during 2002-2004. Using 5176 reconstructed D-s(-)mu(+) signal events, we have measured the B-s(0) lifetime to be tau(B-s(0))=1.398 +/- 0.044(stat)(-0.025)(+0.028)(syst) ps. This is the most precise measurement of the B-s(0) lifetime to date.</p>
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5.
  • Abazov, V. M., et al. (författare)
  • Measurement of the ratios of the Z/gamma*+ &gt;= n jet production cross sections to the total inclusive Z/gamma* cross section in p(p)over-bar collisions at root s=1.96 TeV
  • 2008
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 658:4, s. 112-119
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a study of events with Z bosons and associated jets produced at the Fermilab Tevatron collider in p p collisions at a center of mass energy of 1.96 TeV The data sample consists of nearly 14000 Z/gamma* -&gt; e(+)e(-) candidates corresponding to an integrated luminosity of 0.4 fb(-1) collected with the D circle divide detector. Ratios of the Z/gamma*+ &gt;= n jet cross sections to the total inclusive Z/gamma* cross section have been measured for n = 1-4 jets, and found to be in good agreement with a next-to-leading order QCD calculation and with a tree-level QCD prediction with parton shower simulation and hadronization.</p>
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6.
  • Abazov, V. M., et al. (författare)
  • Search for associated Higgs boson production WH -&gt; WWW*-&gt; l(+/-)nu l('+/-)nu(')+X in p(p)over-bar collisions at root S=1.96 TeV
  • 2006
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:15, s. 151804
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a search for associated Higgs boson production in the process p (p) over bar -&gt; WH -&gt; WWW*-&gt; l(+/-)nu l('+/-)nu(')+X in final states containing two like-sign isolated electrons or muons (e(+/-)e(+/-), e(+/-)mu(+/-), or mu(+/-)mu(+/-)). The search is based on D0 run II data samples corresponding to integrated luminosities of 360-380 pb(-1). No excess is observed over the predicted standard model background. We set 95% C.L. upper limits on sigma -&gt;(p (p) over bar WH) x Br(H -&gt; WW*) between 3.2 and 2.8 pb for Higgs boson masses from 115 to 175 GeV.</p>
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7.
  • Abazov, V. M., et al. (författare)
  • Search for neutral, long-lived particles decaying into two muons in p(p)over-bar collisions at root s=1.96 TeV
  • 2006
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:16, s. 161802
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present a search for a neutral particle, pair produced in pp collisions at root s=1.96 TeV, which decays into two muons and lives long enough to travel at least 5 cm before decaying. The analysis uses approximate to 380 pb(-1) of data recorded with the D0 detector. The background is estimated to be about one event. No candidates are observed, and limits are set on the pair-production cross section times branching fraction into dimuons + X for such particles. For a mass of 10 GeV and lifetime of 4x10(-11) s, we exclude values greater than 0.14 pb (95% C.L.). These results are used to limit the interpretation of NuTeV's excess of dimuon events.</p>
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8.
  • Abazov, V. M., et al. (författare)
  • Search for pair production of scalar bottom quarks in p(p)over-bar collisions at root s = 1.96 TeV
  • 2006
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:17, s. 171806
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>A search for direct production of scalar bottom quarks ((b) over bar) is performed with 310 pb(-1) of data collected by the D0 experiment in p (p) over bar collisions at root s = 1.96 TeV at the Fermilab Tevatron Collider. The topology analyzed consists of two b jets and an imbalance in transverse momentum due to undetected neutralinos (chi(0)(1)), with chi(0)(1) assumed to be the lightest supersymmetric particle. We find the data consistent with standard model expectations, and set a 95% C.L. exclusion domain in the (m(b), m(chi 1)(0)) mass plane, improving significantly upon the results from run I of the Tevatron.</p>
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9.
  • Abazov, V. M., et al. (författare)
  • Search for particles decaying into a Z boson and a photon in p(p)over-bar collisions at root s=1.96 TeV
  • 2006
  • Ingår i: Physics Letters B. - 0370-2693 .- 1873-2445. ; 641:6, s. 415-422
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present the results of a search for a new particle X produced in p (p) over bar collisions at root s- = 1.96 TeV and subsequently decaying to Z gamma. The search uses 0.3 fb(-1) of data collected with the DO detector at the Fermilab Tevatron Collider. We set limits on the production cross section times the branching fraction sigma(p (p) over bar -&gt; X) x B(X -&gt; Z gamma) that range from 0.4 to 3.5 pb at the 95% C.L. for X with invariant masses between 100 and 1000 GeV/c(2), over a wide range of X decay widths.</p>
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10.
  • Abazov, V. M., et al. (författare)
  • Experimental discrimination between charge 2e/3 top quark and charge 4e/3 exotic quark production scenarios
  • 2007
  • Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 98:4, s. 041801
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We present the first experimental discrimination between the 2e/3 and 4e/3 top quark electric charge scenarios, using top quark pairs (t (t) over bar) produced in p (p) over bar collisions at root s =1.96 TeV by the Fermilab Tevatron Collider. We use 370 pb(-1) of data collected by the D0 experiment and select events with at least one high transverse momentum electron or muon, high transverse energy imbalance, and four or more jets. We discriminate between b- and (b) over bar -quark jets by using the charge and momenta of tracks within the jet cones. The data are consistent with the expected electric charge, |q|=2e/3. We exclude, at the 92% C.L., that the sample is solely due to the production of exotic quark pairs Q (Q) over bar with |q|=4e/3. We place an upper limit on the fraction of Q (Q) over bar pairs rho &lt; 0.80 at the 90% C.L.</p>
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