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Sökning: WFRF:(Jimenez Javier)

  • Resultat 1-10 av 53
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  • Blanco, Jose Luis, et al. (författare)
  • A Kalman Filter Based Approach To Probabilistic Gas Distribution Mapping
  • 2013
  • Konferensbidrag (refereegranskat)abstract
    • <p>Building a model of gas concentrations has important indus-trial and environmental applications, and mobile robots ontheir own or in cooperation with stationary sensors play animportant role in this task. Since an exact analytical de-scription of turbulent flow remains an intractable problem,we propose an approximate approach which not only esti-mates the concentrations but also their variances for eachlocation. Our point of view is that of sequential Bayesianestimation given a lattice of 2D cells treated as hidden vari-ables. We first discuss how a simple Kalman filter pro-vides a solution to the estimation problem. To overcomethe quadratic computational complexity with the mappedarea exhibited by a straighforward application of Kalmanfiltering, we introduce a sparse implementation which runsin constant time. Experimental results for a real robot vali-date the proposed method.</p>
  • Boza-Serrano, Antonio, et al. (författare)
  • Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
  • 2019
  • Ingår i: Acta Neuropathologica. - Springer. - 0001-6322. ; 138:2, s. 251-273
  • Tidskriftsartikel (refereegranskat)abstract
    • Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer’s disease) mice and found specifically expressed in microglia associated with Aβ plaques. Single-nucleotide polymorphisms in the LGALS3 gene, which encodes gal3, were associated with an increased risk of AD. Gal3 deletion in 5xFAD mice attenuated microglia-associated immune responses, particularly those associated with TLR and TREM2/DAP12 signaling. In vitro data revealed that gal3 was required to fully activate microglia in response to fibrillar Aβ. Gal3 deletion decreased the Aβ burden in 5xFAD mice and improved cognitive behavior. Interestingly, a single intrahippocampal injection of gal3 along with Aβ monomers in WT mice was sufficient to induce the formation of long-lasting (2 months) insoluble Aβ aggregates, which were absent when gal3 was lacking. High-resolution microscopy (stochastic optical reconstruction microscopy) demonstrated close colocalization of gal3 and TREM2 in microglial processes, and a direct interaction was shown by a fluorescence anisotropy assay involving the gal3 carbohydrate recognition domain. Furthermore, gal3 was shown to stimulate TREM2–DAP12 signaling in a reporter cell line. Overall, our data support the view that gal3 inhibition may be a potential pharmacological approach to counteract AD.
  • Bru, Samuel, et al. (författare)
  • Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae
  • 2016
  • Ingår i: Molecular Microbiology. - 0950-382X .- 1365-2958. ; 101:3, s. 367-380
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Polyphosphate (polyP) is a linear chain of up to hundreds of inorganic phosphate residues that is necessary for many physiological functions in all living organisms. In some bacteria, polyP supplies material to molecules such as DNA, thus playing an important role in biosynthetic processes in prokaryotes. In the present study, we set out to gain further insight into the role of polyP in eukaryotic cells. We observed that polyP amounts are cyclically regulated in Saccharomyces cerevisiae, and those mutants that cannot synthesise (vtc4 Delta) or hydrolyse polyP (ppn1 Delta, ppx1 Delta) present impaired cell cycle progression. Further analysis revealed that polyP mutants show delayed nucleotide production and increased genomic instability. Based on these findings, we concluded that polyP not only maintains intracellular phosphate concentrations in response to fluctuations in extracellular phosphate levels, but also muffles internal cyclic phosphate fluctuations, such as those produced by the sudden demand of phosphate to synthetize deoxynucleotides just before and during DNA duplication. We propose that the presence of polyP in eukaryotic cells is required for the timely and accurate duplication of DNA.</p>
  • Carraminana, Albert, et al. (författare)
  • Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
  • 2019
  • Ingår i: Journal of Cardiothoracic and Vascular Anesthesia. - W B SAUNDERS CO-ELSEVIER INC. - 1053-0770 .- 1532-8422. ; 33:9, s. 2492-2502
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Objective: The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design: International, multicenter, prospective, randomized controlled clinical trial. Setting: A network of university hospitals. Participants: The study comprises 1,380 patients scheduled for thoracic surgery. Interventions: The individualized group will receive intraoperative recruitment maneuvers followed by individualized positive end-expiratory pressure (open lung approach) during the intraoperative period plus postoperative ventilatory support with high-flow nasal cannula, whereas the control group will be managed with conventional lung-protective ventilation. Measurements and Main Results: Individual and total number of postoperative complications, including atelectasis, pneumothorax, pleural effusion, pneumonia, acute lung injury; unplanned readmission and reintubation; length of stay and death in the critical care unit and in the hospital will be analyzed for both groups. The authors hypothesize that the intraoperative application of an open lung approach followed by an individual indication of high-flow nasal cannula in the postoperative period will reduce pulmonary complications and length of hospital stay in high-risk surgical patients. (C) 2019 Published by Elsevier Inc.</p>
  • Ferreira Gonzalez, Javier, 1982- (författare)
  • Textile-enabled Bioimpedance Instrumentation for Personalised Health Monitoring Applications
  • 2013
  • Licentiatavhandling (övrigt vetenskapligt)abstract
    • <p>A growing number of factors, including the costs, technological advancements, an ageing population, and medical errors are leading industrialised countries to invest in research on alternative solutions to improving their health care systems and increasing patients’ life quality. Personal Health System (PHS) solutions envision the use of information and communication technologies that enable a paradigm shift from the traditional hospital-centred healthcare delivery model toward a preventive and person-centred approach. PHS offers the means to follow patient health using wearable, portable or implantable systems that offer ubiquitous, unobtrusive bio-data acquisition, allowing remote access to patient status and treatment monitoring.</p><p>Electrical Bioimpedance (EBI) technology is a non-invasive, quick and relatively affordable technique that can be used for assessing and monitoring different health conditions, e.g., body composition assessments for nutrition. EBI technology combined with state-of-the-art advances in sensor and textile technology are fostering the implementation of wearable bioimpedance monitors that use functional garments for the implementation of personalised healthcare applications.</p><p>This research studies the development of a portable EBI spectrometer that can use dry textile electrodes for the assessment of body composition for the purposes of clinical uses. The portable bioimpedance monitor has been developed using the latest advances in system-on-chip technology for bioimpedance spectroscopy instrumentation. The obtained portable spectrometer has been validated against commercial spectrometer that performs total body composition assessment using functional textrode garments.</p><p>The development of a portable Bioimpedance spectrometer using functional garments and dry textile electrodes for body composition assessment has been shown to be a feasible option. The availability of such measurement systems bring closer the real implementation of personalised healthcare systems.</p>
  • García-Gallego, Sandra, et al. (författare)
  • Polyanionic N-donor ligands as chelating agents in transition metal complexes : synthesis, structural characterization and antiviral properties against HIV
  • 2012
  • Ingår i: Dalton Transactions. - Royal Society of Chemistry. - 1477-9226 .- 1477-9234. ; 41:21, s. 6488-99
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>We describe here the synthesis and characterization of new sulfonated and carboxylated-containing N-donor ligands [Na(4)(edts)]·4H(2)O (2), [Na(2)(dmeddp)]·2H(2)O (3) and [Na(4)(edtp)]·H(2)O (4) (edts = ethylene-diamine- N,N,N',N'-tetraethylenesulfonate ion; dmeddp = dimethyl-ethylene-diamine-N,N,N',N'-tetra-3-propionate ion; edtp = ethylene-diamine-N,N,N',N'-tetra-3-propionate ion) and their corresponding metal (Ni, Co, Cu and Zn) complexes. Mainly, UV-Vis and a computer aided analysis of the EPR spectra provided information on the geometry and structure of the complexes in solution. Some of the metal complexes inhibit HIV replication when treating both pre- and post-infected PBMC cells, and hustle the inhibitory effect compared to the metal salts alone.</p>
  • Gonzàlez Monroy, Javier, et al. (författare)
  • Probabilistic gas quantification with MOX sensors in open sampling systems : a gaussian process approach
  • 2013
  • Ingår i: Sensors and actuators. B, Chemical. - Elsevier. - 0925-4005 .- 1873-3077. ; 188, s. 298-312
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Gas quantification based on the response of an array of metal oxide (MOX) gas sensors in an Open Sampling System is a complex problem due to the highly dynamic characteristic of turbulent airflow and the slow dynamics of the MOX sensors. However, many gas related applications require to determine the gas concentration the sensors are being exposed to. Due to the chaotic nature that dominates gas dispersal, in most cases it is desirable to provide, together with an estimate of the mean concentration, an estimate of the uncertainty of the prediction. This work presents a probabilistic approach for gas quantification with an array of MOX gas sensors based on Gaussian Processes, estimating for every measurement of the sensors a posterior distribution of the concentration, from which confidence intervals can be obtained. The proposed approach has been tested with an experimental setup where an array of MOX sensors and a Photo Ionization Detector (PID), used to obtain ground truth concentration, are placed downwind with respect to the gas source. Our approach has been implemented and compared with standard gas quantification methods, demonstrating the advantages when estimating gas concentrations.</p>
  • Ibanez, Borja, et al. (författare)
  • Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials : JACC Scientific Expert Panel
  • 2019
  • Ingår i: Journal of the American College of Cardiology. - Elsevier USA. - 0735-1097. ; 74:2, s. 238-256
  • Forskningsöversikt (refereegranskat)abstract
    • After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.
  • Monroy, Javier G., et al. (författare)
  • Calibration of mox gas sensors in open sampling systems based on gaussian processes
  • 2012
  • Ingår i: Proceedings of the IEEE Sensors Conference, 2012. - IEEE conference proceedings. - 978-1-4577-1765-9 ; s. 1-4
  • Konferensbidrag (refereegranskat)abstract
    • <p>Calibration of metal oxide (MOX) gas sensor for continuous monitoring is a complex problem due to the highly dynamic characteristics of the gas sensor signal when exposed to natural environment (Open Sampling System - OSS). This work presents a probabilistic approach to the calibration of a MOX gas sensor based on Gaussian Processes (GP). The proposed approach estimates for every sensor measurement a probability distribution of the gas concentration. This enables the calculation of confidence intervals for the predicted concentrations. This is particularly important since exact calibration is hard to obtain due to the chaotic nature that dominates gas dispersal. The proposed approach has been tested with an experimental setup where an array of MOX sensors and a Photo Ionization Detector (PID) are placed downwind w.r.t. the gas source. The PID is used to obtain ground truth concentration. Comparison with standard calibration methods demonstrates the advantage of the proposed approach.</p>
  • Monroy, Javier, et al. (författare)
  • GADEN A 3D Gas Dispersion Simulator for Mobile Robot Olfaction in Realistic Environments
  • 2017
  • Ingår i: Sensors. - MDPI AG. - 1424-8220. ; 17:7
  • Tidskriftsartikel (refereegranskat)abstract
    • This work presents a simulation framework developed under the widely used Robot Operating System (ROS) to enable the validation of robotics systems and gas sensing algorithms under realistic environments. The framework is rooted in the principles of computational fluid dynamics and filament dispersion theory, modeling wind flow and gas dispersion in 3D real-world scenarios (i.e., accounting for walls, furniture, etc.). Moreover, it integrates the simulation of different environmental sensors, such as metal oxide gas sensors, photo ionization detectors, or anemometers. We illustrate the potential and applicability of the proposed tool by presenting a simulation case in a complex and realistic office-like environment where gas leaks of different chemicals occur simultaneously. Furthermore, we accomplish quantitative and qualitative validation by comparing our simulated results against real-world data recorded inside a wind tunnel where methane was released under different wind flow profiles. Based on these results, we conclude that our simulation framework can provide a good approximation to real world measurements when advective airflows are present in the environment.
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