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Sökning: WFRF:(Jirström Magnus)

  • Resultat 1-10 av 89
  • [1]234567...9Nästa
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1.
  • Corvigno, Sara, et al. (författare)
  • Multi-parametric profiling of renal cell, colorectal, and ovarian cancer identifies tumour-type-specific stroma phenotypes and a novel vascular biomarker
  • Ingår i: The Journal of Pathology: Clinical Research. - : Wiley-Blackwell Publishing Ltd. - 2056-4538. ; 3:3, s. 214-224
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract A novel set of integrated procedures for quantification of fibroblast-rich stroma and vascular characteristics has recently been presented allowing discovery of novel perivascular and stromal biomarkers in colorectal, renal cell, and ovarian cancer. In the present study, data obtained through these procedures from clinically well-annotated collections of these three tumour types have been used to address two novel questions. First, data have been used to investigate if the three tumour types demonstrate significant differences regarding features such as vessel diameter, vessel density, and perivascular marker expression. Second, analyses of the cohorts have been used to explore the prognostic significance of a novel vascular metric, ?vessel distance inter-quartile range (IQR)? that describes intra-case heterogeneity regarding vessel distribution. The comparisons between the three tumour types demonstrated a set of significant differences. Vessel density of renal cell cancer was statistically significantly higher than in colorectal and ovarian cancer. Vessel diameter was statistically significantly higher in ovarian cancer. Concerning perivascular status, colorectal cancer displayed significantly higher levels of perivascular PDGFR-? expression than the other two tumour types. Intra-case heterogeneity of perivascular PDGFR-? expression was also higher in colorectal cancer. Notably, these fibroblast-dominated stroma phenotypes matched previously described experimental tumour stroma characteristics, which have been linked to differential sensitivity to anti-VEGF drugs. High ?vessel distance IQR? was significantly associated with poor survival in both renal cell cancer and colorectal cancer. In renal cell cancer, this characteristic also acted as an independent prognostic marker according to multivariate analyses including standard clinico-pathological characteristics. Explorative subset analyses indicated particularly strong prognostic significance of ?vessel distance IQR? in T stage 4 of this cancer type. Together, these analyses identified tumour-type-specific vascular-stroma phenotypes of possible functional significance, and suggest ?vessel distance IQR? as a novel prognostic biomarker.
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  • Jirström, Magnus, et al. (författare)
  • The State and Green Revolutions in East Asia
  • 2005
  • Ingår i: The African Food Crisis: Lessons from the Asian Green Revolution. - : CABI Publishing. - 0851999980 ; , s. 25-42
  • Bokkapitel (refereegranskat)
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4.
  • Eldh, Christer, et al. (författare)
  • Från nybyggaranda till kreativ ordning
  • 2015
  • Ingår i: Samhällsvetenskapliga fakulteten i Lund - en vital 50-åring. En jubileumsskrift. - : Samhällsvetenskapliga fakulteten, Lunds universitet. - 9789176233597 ; , s. 249-269
  • Bokkapitel (populärvet., debatt m.m.)
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5.
  • Ghanipour, L., et al. (författare)
  • Associations of defect mismatch repair genes with prognosis and heredity in sporadic colorectal cancer
  • Ingår i: European Journal of Surgical Oncology. - : Elsevier. - 0748-7983 .- 1532-2157. ; 43:2, s. 311-321
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Microsatellite instability arises due to defect mismatch repair (MMR) and occurs in 10–20% of sporadic colorectal cancer. The purpose was to investigate correlations between defect MMR, prognosis and heredity for colorectal cancer in first-degree relatives. Material and methods Tumour tissues from 318 patients consecutively operated for colorectal cancer were analysed for immunohistochemical expression of MLH1, MSH2 and MSH6 on tissue microarrays. Information on KRAS and BRAF mutation status was available for selected cases. Results Forty-seven (15%) tumours displayed MSI. No correlation was seen between patients exhibiting MSI in the tumour and heredity (p = 0.789). Patients with proximal colon cancer and MSI had an improved cancer-specific survival (p = 0.006) and prolonged time to recurrence (p = 0.037). In a multivariate analysis including MSI status, gender, CEA, vascular and neural invasion, patients with MSS and proximal colon cancer had an impaired cancer-specific survival compared with patients with MSI (HR, 4.32; CI, 1.46–12.78). The same prognostic information was also seen in distal colon cancer; no recurrences seen in the eight patients with stages II and III distal colon cancer and MSI, but the difference was not statistically significant. Conclusion No correlation between MSI and heredity for colorectal cancer in first-degree relatives was seen. Patients with MSI tumours had improved survival.
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6.
  • Nodin, Björn, et al. (författare)
  • Clinicopathological correlates and prognostic significance of KRAS mutation status in a pooled prospective cohort of epithelial ovarian cancer
  • 2013
  • Ingår i: Diagnostic Pathology. - : BioMed Central (BMC). - 1746-1596. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Activating KRAS mutations are common in ovarian carcinomas of low histological grade, less advanced clinical stage and mucinous histological subtype, and form part of the distinct molecular alterations associated with type I tumors in the dualistic model of ovarian carcinogenesis. Here, we investigated the occurrence, clinicopathological correlates and prognostic significance of specific KRAS mutations in tumours from 153 epithelial ovarian cancer (EOC) cases from a pooled, prospective cohort. Methods: KRAS codon 12,13 and 61 mutations were analysed by pyrosequencing in tumours from 163 incident EOC cases in the Malmo Diet and Cancer Study and Malmo Preventive Project. Associations of mutational status with clinicopathological and molecular characteristics were assessed by Pearson Chi Square test. Ovarian cancer-specific survival (OCSS) according to mutational status was explored by Kaplan-Meier analysis and Cox proportional hazards modelling. KRAS-mutation status was also analysed in 28 concomitantly sampled benign-appearing fallopian tubes. Results: Seventeen (11.1%) EOC cases harboured mutations in the KRAS gene, all but one in codon 12, and one in codon 13. No KRAS mutations were found in codon 61 and all examined fallopian tubes were KRAS wild-type. KRAS mutation was significantly associated with lower grade (p = 0.001), mucinous histological subtype (p = < 0.001) and progesterone receptor expression (p = 0.035). Kaplan-Meier analysis revealed a significantly improved OCSS for patients with KRAS-mutated compared to KRAS wild-type tumours (p = 0.015). These associations were confirmed in unadjusted Cox regression analysis (HR = 2.51; 95% CI 1.17-5.42) but did not remain significant after adjustment for age, grade and clinical stage. The beneficial prognostic impact of KRAS mutation was ony evident in tumours of low-intermediate differentiation grade (p = 0.023), and in a less advanced clinical stage (p = 0.014). Moreover, KRAS mutation was associated with a significantly improved OCSS in the subgroup of endometroid carcinomas (p = 0.012). Conclusions: The results from this study confirm previously demonstrated associations of KRAS mutations with well-differentiated and mucinous ovarian carcinomas. Moreover, KRAS-mutated tumours had a significantly improved survival in unadjusted, but not adjusted, analysis. A finding that merits further study is the significant prognostic impact of KRAS mutation in endometroid carcinomas, potentially indicating that response to Ras/Raf/MEK/ERK-targeting therapies may differ by histological subtype.
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  • Akande, T., et al. (författare)
  • Conclusions and a Look Ahead.
  • 2005
  • Ingår i: The African Food Crisis: Lessons from the Asian Green Revolution. - : CABI Publishing. - 0851999980 ; , s. 253-260
  • Bokkapitel (övrigt vetenskapligt)
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10.
  • Alsanius, Beatrix W, et al. (författare)
  • Optimizing horticulture for urban agriculture
  • Ingår i: Achieving sustainable urban agriculture. - : Burleigh Doods Science Publishing Limited. - 9781786763167 ; , s. 1-57
  • Bokkapitel (refereegranskat)
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