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Träfflista för sökning "WFRF:(Johansen Jeanne D) "

Sökning: WFRF:(Johansen Jeanne D)

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  • [1]23Nästa
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1.
  • Christensson, Johanna Brared, et al. (författare)
  • Positive patch test reactions to oxidized limonene: exposure and relevance
  • 2014
  • Ingår i: Contact Dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873 .- 1600-0536. ; 71:5, s. 264-272
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reaction to oxidized R-limonene. Objective. To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized R-limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis. Methods. Oxidized R-limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in Australia, Denmark, the United Kingdom, Singapore, Spain, and Sweden. A questionnaire assessing exposure to limonene-containing products was completed. Results. Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene-allergic patients. In Barcelona and Copenhagen, >70% of the patients were judged to have had an exposure to limonene assessed as relevant. Conclusions. Oxidized R-limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with R-limonene were identified.
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2.
  • Matura, Mihaly, 1964, et al. (författare)
  • Not only oxidized R-(+)- but also S-(-)-limonene is a common cause of contact allergy in dermatitis patients in Europe.
  • 2006
  • Ingår i: Contact dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873. ; 55:5, s. 274-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Limonene, one of the most often used fragrance terpenes in any kind of scented products, is prone to air-oxidation. The oxidation products formed have a considerable sensitizing potential. In previous patch test studies on consecutively tested dermatitis patients, oxidized R-limonene has been proven to be a good and frequent indicator of fragrance-related contact allergy. The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. Altogether, 63 out of 2411 patients tested (2.6%) reacted to 1 or both the oxidized limonene preparations. Only 2.3% reacted to the oxidized R-limonene and 2.0% to the oxidized S-limonene. In 57% of the cases, simultaneous reactions were observed to both oxidation mixtures. Concomitant reactions to the fragrance mix, colophonium, Myroxylon pereirae, and fragrance-related contact allergy were common in patients reacting to 1 or both the oxidized limonene enantiomers. Our study provides clinical evidence for the importance of oxidation products of limonene in contact allergy. It seems advisable to screen consecutive dermatitis patients with oxidized limonene 3% petrolatum, although this patch test material is not yet commercially available.
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3.
  • Bråred Christensson, Johanna, 1965, et al. (författare)
  • An international multicentre study on the allergenic activity of air-oxidized R-limonene
  • 2013
  • Ingår i: Contact Dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873. ; 68:4, s. 214-223
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2–3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3–12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0–24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.
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4.
  • Hamann, Dathan, et al. (författare)
  • Jewellery : alloy composition and release of nickel, cobalt and lead assessed with the EU synthetic sweat method
  • 2015
  • Ingår i: Contact Dermatitis. - 0105-1873 .- 1600-0536. ; 73:4, s. 231-238
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Several studies have shown nickel and cobalt release from jewellery by using spot tests, but the metal composition of jewellery is largely unknown. Objectives. To evaluate the metal composition of a large worldwide sample of mainly inexpensive jewellery items, and investigate the release of nickel, cobalt and lead from a subsample by using EN 1811: 1998-required methods. Methods. A total of 956 metallic jewellery components were examined with X-ray fluorescence spectroscopy. A subsample of 96 jewellery items purchased in the United States were investigated for nickel, cobalt and lead release by the use of artificial sweat immersion and plasma optical emission spectroscopy. Results. Eighteen elements were detected. The 10 most frequently occurring were, in order of frequency, copper, iron, zinc, nickel, silver, chromium, tin, manganese, lead, and cobalt. Release of nickelwas noted from 79 of the 96 US samples (0.01-98 mu g/cm(2)/week), release of cobalt from 35 samples (0.02-0.5 mu g/cm(2)/week), and release of lead from 37 samples (0.03-2718 mu g/cm(2)/week). Conclusions. We present here a comprehensive list of the most frequently encountered metals in jewellery and fashion accessories. Different allergenic and non-allergenic metals are utilized. We also report the frequent release of nickel, cobalt and lead from these objects, despite legislative restrictions.
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5.
  • Jakobsen, Stig S., et al. (författare)
  • Failure of total hip implants : metals and metal release in 52 cases
  • 2014
  • Ingår i: Contact Dermatitis. - 0105-1873 .- 1600-0536. ; 71:6, s. 319-325
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundThe pathogenesis of total joint replacement failure is multifactorial. One hypothesis suggests that corrosion and wear of alloys result in metal ion release, which may then cause sensitization and even implant failure, owing to the acquired immune reactivity. ObjectivesTo assess cobalt, nickel and chromium(VI) release from, and the metal composition of, failed metal-on-ethylene total hip replacements. Materials/methodsImplant components from 52 revision cases were evaluated with spot tests for free nickel, cobalt, and chromium (VI) ions. Implant composition was determined with X-ray fluorescence spectroscopy, and information on the reason for revision and complications in relation to surgery was collected from the medical charts when possible (72%). For 10 implants, corrosion was further characterized with scanning electron microscopy. ResultsWe detected cobalt release from three of 38 removed femoral heads and from one of 24 femoral stems. Nickel release was detected from one of 24 femoral stems. No chromium(VI) release was detected. ConclusionsWe found that cobalt and nickel were released from some failed total hip arthroplasties, and corrosion was frequently observed. Metal ions and particles corroded from metal-on-polyethylene may play a role in the complex aetiopathology of implant failure.
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6.
  • Johansen, Jeanne D, et al. (författare)
  • European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice.
  • 2015
  • Ingår i: Contact Dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873 .- 1600-0536. ; 73:4, s. 195-221
  • Forskningsöversikt (refereegranskat)abstract
    • The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance.
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7.
  • Schalock, Peter C, et al. (författare)
  • Hypersensitivity reactions to metallic implants-diagnostic algorithm and suggested patch test series for clinical use.
  • 2012
  • Ingår i: Contact Dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873 .- 1600-0536. ; 66:1, s. 4-19
  • Tidskriftsartikel (refereegranskat)abstract
    • Cutaneous and systemic hypersensitivity reactions to implanted metals are challenging to evaluate and treat. Although they are uncommon, they do exist, and require appropriate and complete evaluation. This review summarizes the evidence regarding evaluation tools, especially patch and lymphocyte transformation tests, for hypersensitivity reactions to implanted metal devices. Patch test evaluation is the gold standard for metal hypersensitivity, although the results may be subjective. Regarding pre-implant testing, those patients with a reported history of metal dermatitis should be evaluated by patch testing. Those without a history of dermatitis should not be tested unless considerable concern exists. Regarding post-implant testing, a subset of patients with metal hypersensitivity may develop cutaneous or systemic reactions to implanted metals following implant. For symptomatic patients, a diagnostic algorithm to guide the selection of screening allergen series for patch testing is provided. At a minimum, an extended baseline screening series and metal screening is necessary. Static and dynamic orthopaedic implants, intravascular stent devices, implanted defibrillators and dental and gynaecological devices are considered. Basic management suggestions are provided. Our goal is to provide a comprehensive reference for use by those evaluating suspected cutaneous and systemic metal hypersensitivity reactions.
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8.
  • Bennike, Niels H., et al. (författare)
  • Allergic contact dermatitis caused by hydroperoxides of limonene and dose-response relationship-A repeated open application test (ROAT) study
  • 2019
  • Ingår i: Contact Dermatitis. - 0105-1873 .- 1600-0536. ; 80:4, s. 208-216
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim-OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported. Objectives: To determine the clinical relevance, elicitation threshold and dose-response relationship of Lim-OOHs in individuals with a positive or doubtful patch test reaction to standard Lim-OOHs 0.3% pet. Methods: A multicentre 3-week double-blind vehicle-controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim-OOHs at 1260, 420 and 140 ppm, equal to a dose/area per application of Lim-OOHs of 3.0, 0.99 and 0.33 mu g/cm(2), was performed. Results: Among 11 subjects allergic to Lim-OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (P < 0.0001). Among 13 subjects with doubtful patch test reactions to Lim-OOHs, two (15%) had positive ROAT reactions to the highest Lim-OOH dose applied (P = 0.36 as compared with controls). Conclusions: Contact allergy to Lim-OOHs is of clinical relevance in patients with positive patch test reactions. A doubtful patch test reaction to Lim-OOHs 0.3% pet. can be of clinical relevance.
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9.
  • Bennike, Niels H, et al. (författare)
  • Allergic contact dermatitis to hydroperoxides of limonene and dose-response relationship - a repeated open application test (ROAT) study.
  • 2019
  • Ingår i: Contact dermatitis. - 1600-0536. ; 80:4, s. 208-216
  • Tidskriftsartikel (refereegranskat)abstract
    • Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim-OOHs) as main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported.To determine clinical relevance, elicitation threshold, and dose-response relationship of Lim-OOHs in individuals with a positive or doubtful patch test to standard Lim-OOHs 0.3% pet.A multicentre 3-week double-blinded vehicle-controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim-OOHs at 1260 ppm, 420 ppm, and 140 ppm, equal to a dose/area per application of Lim-OOHs of 3.0 μg/cm2 , 0.99 μg/cm2 , and 0.33 μg/cm2 .Among 11 subjects allergic to Lim-OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (P<0.0001). Among 13 subjects with a doubtful patch test to Lim-OOHs, two (15%) had a positive ROAT to the highest Lim-OOHs dose applied (P=0.36 compared to controls).Contact allergy to Lim-OOHs is of clinical relevance in patients with a positive patch test. A doubtful patch test to Lim-OOHs 0.3% pet. can be of clinical relevance. This article is protected by copyright. All rights reserved.
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10.
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