SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Johansson Bengt 1964 ) "

Sökning: WFRF:(Johansson Bengt 1964 )

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Elgqvist, Jörgen, 1963-, et al. (författare)
  • Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab')2.
  • 2006
  • Ingår i: International journal of radiation oncology, biology, physics. - 1879-355X. ; 66:4, s. 1228-37
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To elucidate the therapeutic efficacy of alpha-radioimmunotherapy of ovarian cancer in mice. This study: (i) estimated the minimum required activity (MRA), giving a reasonable high therapeutic efficacy; and (ii) calculated the specific energy to tumor cell nuclei and the metastatic cure probability (MCP) using various assumptions regarding monoclonal-antibody (mAb) distribution in measured tumors. The study was performed using the alpha-particle emitter Astatine-211 (211At) labeled to the mAb MX35 F(ab')2. METHODS AND MATERIALS: Animals were inoculated intraperitoneally with approximately 1 x 10(7) cells of the cell line NIH:OVCAR-3. Four weeks later animals were treated with 25, 50, 100, or 200 kBq 211At-MX35 F(ab')2 (n = 74). Another group of animals was treated with a nonspecific mAb: 100 kBq 211At-Rituximab F(ab')2 (n = 18). Eight weeks after treatment the animals were sacrificed and presence of macro- and microscopic tumors and ascites was determined. An MCP model was developed and compared with the experimentally determined tumor-free fraction (TFF). RESULTS: When treatment was given 4 weeks after cell inoculation, the TFFs were 25%, 22%, 50%, and 61% after treatment with 25, 50, 100, or 200 kBq (211)At-MX35 F(ab')2, respectively, the specific energy to irradiated cell nuclei varying between approximately 2 and approximately 400 Gy. CONCLUSION: As a significant increase in the therapeutic efficacy was observed between the activity levels of 50 and 100 kBq (TFF increase from 22% to 50%), the conclusion was that the MRA is approximately 100 kBq (211)At-MX35 F(ab')2. MCP was most consistent with the TFF when assuming a diffusion depth of 30 mum of the mAbs in the tumors.
  •  
3.
  • Elgqvist, Jörgen, 1963-, et al. (författare)
  • Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed dose.
  • 2006
  • Ingår i: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - 0161-5505. ; 47:8, s. 1342-50
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this work was to (a) investigate the efficacy of radioimmunotherapy using 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2 (nonspecific antibody) against differently advanced ovarian cancer in mice; (b) image the tumor growth on the peritoneum; and (c) calculate the specific energy and mean absorbed dose to tumors and critical organs. METHODS: Two experiments with 5-wk-old nude mice (n = 100 + 93), intraperitoneally inoculated with approximately 1 x 10(7) NIH:OVCAR-3 cells, were done. At either 1, 3, 4, 5, or 7 wk after inoculation animals were intraperitoneally treated with approximately 400 kBq 211At-MX35 F(ab')2 (n = 50 + 45), approximately 400 kBq 211At-Rituximab F(ab')2 (n = 25 + 24), or unlabeled Rituximab F(ab')2 (n = 25 + 24). At the time of treatment 29 animals were sacrificed and biopsies were taken for determination of tumor sizes using scanning electron microscopy (SEM). Eight weeks after each treatment the animals were sacrificed and the presence of macro- and microscopic tumors and ascites was determined. The specific energy and mean absorbed dose to tumors were calculated. The activity concentration was measured in critical organs and abdominal fluid. RESULTS: When given treatment 1, 3, 4, 5, or 7 wk after cell inoculation the tumor-free fraction (TFF) was 95%, 68%, 58%, 47%, 26%, and 100%, 80%, 20%, 20%, and 0% when treated with 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2, respectively. The SEM images revealed maximum tumor radius of approximately 30 mum 1 wk after cell inoculation, increasing to approximately 340 mum at 7 wk. Specific energy to cell nuclei varied between 0 and approximately 540 Gy, depending on assumptions regarding activity distribution and tumor size. The mean absorbed dose to thyroid, kidneys, and bone marrow was approximately 35, approximately 4, and approximately 0.3 Gy, respectively. CONCLUSION: Treatment with 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2 resulted in a TFF of 95%-100% when the tumor radius was
  •  
4.
  • Fragment
  • 2015
  • Samlingsverk (redaktörskap) (övrigt vetenskapligt)
  •  
5.
  •  
6.
  •  
7.
  • Johansson, Folke, 1943-, et al. (författare)
  • Kommunstorlek och demokrati
  • 2007
  • Bok (övrigt vetenskapligt)abstract
    • Föreliggande rapport har utarbetats vid CEFOS, Centrum för forskning om offentlig sektor, Göteborgs universitet. Huvudsyftet har varit att ta fram aktuell och systematisk kunskap om den betydelse kommunstorleken har för hur den kommunala demokratin i Sverige fungerar. Rapporten bygger till största delen på reanalyser av ett befintligt omfattande empiriskt material som innefattar kommunstudier av såväl medborgare som politiker, studier av massmediers innehåll och de mer generella enkätundersökningar som sedan lång tid utförs vid SOM-institutet, Göteborgs universitet. Beträffande politiker har också nytt material samlats in. Huvudansvariga för rapporten är professor Folke Johansson och fil dr David Karlsson. Docent Bengt Johansson har medverkat med analys av massmedias roll och fil dr Ylva Norén Bretzer har medverkat med analys av förtroende för politiker.
  •  
8.
  •  
9.
  • Albertsson, Per, 1964-, et al. (författare)
  • Differential locomotion of long- and short-term IL-2-activated murine natural killer cells in a model matrix environment.
  • 2007
  • Ingår i: Scandinavian journal of immunology. - 0300-9475. ; 66:4, s. 402-9
  • Tidskriftsartikel (refereegranskat)abstract
    • Tumour infiltration by activated natural killer (A-NK) cells is a pre-requisite for tumour eradication by adoptive NK cell transfer. Extravasated A-NK cells do not always succeed in reaching the crucial target cell conjugation. Therefore, we wished to study A-NK cell locomotion and interactions with melanoma cells in a matrix environment (Matrigel) by electron, confocal and fluorescence microscopy. Two distinct patterns of A-NK cell-mediated matrix disintegration were revealed during incubation of tumour cells and A-NK cells in Matrigel: (1) A-NK cells pre-cultured for 5 days altered the homogeneous texture of the Matrigel, an initial microporous appearance became a loose filamentous meshwork by 24 h. Matrix degrading protease inhibitors could not fully prevent this, but could delay the process; and (2) A-NK cells pre-cultured for 6 days or more, instead formed large excavations in the Matrigel leaving the remaining matrix less affected compared to the effects by the younger A-NK cells. By histochemical staining with Cupromeronic Blue, the excavations were shown to contain proteoglycan material. Protease inhibitors had no discernable effect on the development of the excavations. The conspicuous capacity of A-NK cells to disintegrate extracellular matrix and the formation of large excavations seems only partially to depend on matrix-degrading proteases. Formation of extracellular proteoglycan material is suggested to facilitate A-NK cell locomotion within a matrix environment.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
Åtkomst
fritt online (6)
Typ av publikation
tidskriftsartikel (101)
bokkapitel (71)
konferensbidrag (31)
rapport (13)
bok (9)
samlingsverk (redaktörskap) (7)
visa fler...
doktorsavhandling (1)
visa färre...
Typ av innehåll
övrigt vetenskapligt (124)
populärvet., debatt m.m. (60)
refereegranskat (49)
Författare/redaktör
Johansson, Bengt, 19 ... (210)
Johansson, Bengt R, ... (13)
Ekström, Mats, 1961- ... (10)
Andersson Odén, Toma ... (10)
Håkansson, Nicklas, (9)
Vigsø, Orla, 1962-, (9)
visa fler...
Djerf-Pierre, Monika ... (7)
Albertsson, Per, 196 ... (7)
Nannmark, Ulf, 1958- ... (6)
Truedson, Lars (6)
Asp, Kent, 1949-, (6)
Ghersetti, Marina, 1 ... (5)
Bengtsson, Stina, 19 ... (5)
Sandstig, Gabriella, ... (5)
Strömbäck, Jesper, 1 ... (4)
Larsson, Larsåke, (4)
Novelli, Edoardo (3)
Strömbäck, Jesper, (3)
Goldfarb, R H (3)
Nordén, Bengt, 1945- ... (3)
Ekström, Mats, (3)
Kann, Nina, 1964-, (3)
Warnhammar Finnborg, ... (2)
Hultborn, Ragnar, 19 ... (2)
Hagberg, Henrik, 195 ... (2)
Fridlund, Bengt, (2)
Wang, Xiaoyang, 1965 ... (2)
Zhu, Changlian, 1964 ... (2)
Lennernäs, Bo, 1963- ... (2)
Basse, P H (2)
Edsparr, Karin, 1979 ... (2)
Kim, M H (2)
Kitson, R P (2)
Jonges, L. E. (2)
Kuppen, P. J. (2)
Palm, Stig, 1964-, (2)
Svensson, Johan, 196 ... (2)
Jensen, Holger (2)
Johansson, Dan, 1964 ... (2)
Andersson, Håkan, 19 ... (2)
Elgqvist, Jörgen, 19 ... (2)
Jacobsson, Lars, 194 ... (2)
Lindegren, Sture, 19 ... (2)
Bäck, Tom, 1964-, (2)
Mölleryd, Bengt, (2)
Fredriksson, Magnus, ... (2)
Karlsson, Michael (2)
Karlson, Nils, (2)
Olsson, Marita, 1965 ... (2)
Ringsberg, Karin C., ... (2)
visa färre...
Lärosäte
Göteborgs universitet (225)
Chalmers tekniska högskola (5)
Uppsala universitet (2)
Örebro universitet (2)
Linköpings universitet (2)
Högskolan i Jönköping (2)
visa fler...
Södertörns högskola (2)
Lunds universitet (1)
Högskolan i Halmstad (1)
Linnéuniversitetet (1)
visa färre...
Språk
Svenska (150)
Engelska (83)
Forskningsämne (UKÄ/SCB)
Samhällsvetenskap (213)
Medicin och hälsovetenskap (19)
Naturvetenskap (5)
Humaniora (2)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy