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- Andersen, Kim, et al.
(författare)
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Maintenance and Reformation of News Repertoires: A Latent Transition Analysis
- 2022
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Ingår i: Journalism & Mass Communication Quarterly. - : SAGE Publications. - 1077-6990 .- 2161-430X. ; 99:1
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Tidskriftsartikel (refereegranskat)abstract
- Today’s media environment provides people ample opportunities for constructing news habits fitting their preferences, but our knowledge about the dynamics of such news habits is limited. Using a four-wave panel survey from Sweden and taking a news repertoires approach, the study identifies four groups of news users labeled Public service-oriented traditionalists, Minimalists, Engaged pluralists, and Quality-oriented explorers, which are each related to news interest, trust in mainstream news media, and socio-demographic factors in distinct ways. The news repertoires are highly stable, even during profound contextual change, showing that people most often maintain their news habits and only seldom reform them.
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- Elgqvist, Jörgen, 1963, et al.
(författare)
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Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab')2.
- 2006
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Ingår i: International journal of radiation oncology, biology, physics. - : Elsevier BV. - 1879-355X .- 0360-3016. ; 66:4, s. 1228-37
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To elucidate the therapeutic efficacy of alpha-radioimmunotherapy of ovarian cancer in mice. This study: (i) estimated the minimum required activity (MRA), giving a reasonable high therapeutic efficacy; and (ii) calculated the specific energy to tumor cell nuclei and the metastatic cure probability (MCP) using various assumptions regarding monoclonal-antibody (mAb) distribution in measured tumors. The study was performed using the alpha-particle emitter Astatine-211 (211At) labeled to the mAb MX35 F(ab')2. METHODS AND MATERIALS: Animals were inoculated intraperitoneally with approximately 1 x 10(7) cells of the cell line NIH:OVCAR-3. Four weeks later animals were treated with 25, 50, 100, or 200 kBq 211At-MX35 F(ab')2 (n = 74). Another group of animals was treated with a nonspecific mAb: 100 kBq 211At-Rituximab F(ab')2 (n = 18). Eight weeks after treatment the animals were sacrificed and presence of macro- and microscopic tumors and ascites was determined. An MCP model was developed and compared with the experimentally determined tumor-free fraction (TFF). RESULTS: When treatment was given 4 weeks after cell inoculation, the TFFs were 25%, 22%, 50%, and 61% after treatment with 25, 50, 100, or 200 kBq (211)At-MX35 F(ab')2, respectively, the specific energy to irradiated cell nuclei varying between approximately 2 and approximately 400 Gy. CONCLUSION: As a significant increase in the therapeutic efficacy was observed between the activity levels of 50 and 100 kBq (TFF increase from 22% to 50%), the conclusion was that the MRA is approximately 100 kBq (211)At-MX35 F(ab')2. MCP was most consistent with the TFF when assuming a diffusion depth of 30 mum of the mAbs in the tumors.
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- Elgqvist, Jörgen, 1963, et al.
(författare)
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Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed dose.
- 2006
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Ingår i: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - 0161-5505 .- 2159-662X. ; 47:8, s. 1342-50
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this work was to (a) investigate the efficacy of radioimmunotherapy using 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2 (nonspecific antibody) against differently advanced ovarian cancer in mice; (b) image the tumor growth on the peritoneum; and (c) calculate the specific energy and mean absorbed dose to tumors and critical organs. METHODS: Two experiments with 5-wk-old nude mice (n = 100 + 93), intraperitoneally inoculated with approximately 1 x 10(7) NIH:OVCAR-3 cells, were done. At either 1, 3, 4, 5, or 7 wk after inoculation animals were intraperitoneally treated with approximately 400 kBq 211At-MX35 F(ab')2 (n = 50 + 45), approximately 400 kBq 211At-Rituximab F(ab')2 (n = 25 + 24), or unlabeled Rituximab F(ab')2 (n = 25 + 24). At the time of treatment 29 animals were sacrificed and biopsies were taken for determination of tumor sizes using scanning electron microscopy (SEM). Eight weeks after each treatment the animals were sacrificed and the presence of macro- and microscopic tumors and ascites was determined. The specific energy and mean absorbed dose to tumors were calculated. The activity concentration was measured in critical organs and abdominal fluid. RESULTS: When given treatment 1, 3, 4, 5, or 7 wk after cell inoculation the tumor-free fraction (TFF) was 95%, 68%, 58%, 47%, 26%, and 100%, 80%, 20%, 20%, and 0% when treated with 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2, respectively. The SEM images revealed maximum tumor radius of approximately 30 mum 1 wk after cell inoculation, increasing to approximately 340 mum at 7 wk. Specific energy to cell nuclei varied between 0 and approximately 540 Gy, depending on assumptions regarding activity distribution and tumor size. The mean absorbed dose to thyroid, kidneys, and bone marrow was approximately 35, approximately 4, and approximately 0.3 Gy, respectively. CONCLUSION: Treatment with 211At-MX35 F(ab')2 or 211At-Rituximab F(ab')2 resulted in a TFF of 95%-100% when the tumor radius was < or =30 microm. The TFF was decreased (TFF < or = 20%) for 211At-Rituximab F(ab')2 when the tumor radius exceeded the range of the alpha-particles. The specific antibody gave for these tumor sizes a significantly better TFF, explained by a high mean absorbed dose (>22 Gy) from the activity bound to the tumor surface and probably some contribution from penetrating activity.
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- Shehata, Adam, 1981, et al.
(författare)
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Climate Change Frame Acceptance and Resistance: Extreme Weather, Consonant News, and Personal Media Orientations
- 2022
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Ingår i: Mass Communication & Society. - : Informa UK Limited. - 1520-5436 .- 1532-7825. ; 25:1, s. 51-76
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Tidskriftsartikel (refereegranskat)abstract
- Across the globe, extreme weather events have brought climate change into people’s daily lives. Extended heatwaves, droughts, and wildfires are now recurring in many regions across the globe. This study asks how the exceptional 2018 summer influenced climate change beliefs among Swedish citizens. More specifically, the study looks deeper into belief formation dynamics under intense, consonant, and extended news reporting–addressing one of the most fundamental media effects in the literature: the over-time maintenance of societal beliefs through cumulative and repetitive exposure to a dominant issue frame. Using a unique three-wave panel survey, the analysis focuses on citizens’ acceptance (and resistance) of the dominant climate change frame provided by traditional media–whether citizens believe in the existence, causes, and consequences of climate change. The findings reveal strong support for belief maintenance effects over time, but also that belief changes are possible. Even in situations of intense and consonant news reporting, acceptance (and resistance) of the dominant climate change frame depends on citizens’ personal media orientations. Both trust in traditional news media and usage of alternative online news emerge as key factors conditioning classic media effects in a fragmented and polarized media environment.
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- Theorin, Nora, 1989, et al.
(författare)
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Valfusk i Sverige? Allmänhetens syn på oegentligheter vid svenska val
- 2023
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Ingår i: Statsvetenskaplig Tidsskrift. - 0039-0747. ; 125:4
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Tidskriftsartikel (refereegranskat)abstract
- A fundamental precondition for the legitimacy of democracy is a high level of trust in the electoral process. It is therefore concerning that the number of appeals regarding electoral fraud has increased, that allegations of frauds circulate on social media, and that research indicates that a significant portion of the Swedish population does not fully trust that elections are conducted in a correct manner. At the same time, there is a lack of studies examining the nature of electoral distrust and the prevalence of conspiratorial beliefs regarding Swedish elections. Hence, the purpose of this study is to investigate (a) the extent of belief in irregulari-ties related to vote counting and ballot placement, (b) whether the proportion of those believing in such irregularities changes during an election campaign, and (c) the factors driving belief in conspiratorial claims of electoral fraud. The results of a panel study conducted during the 2022 election campaign indicate that the major-ity does not believe in conspiratorial claims of electoral fraud. However, there is a minority—characterized by a high degree of conspiracy thinking—who believes irregularities are common during Swedish elections. Furthermore, the results sug-gest that other explanatory factors for belief in electoral fraud include the use of right-wing alternative media and sympathy towards the Sweden Democrats.
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- Albertsson, Per, 1964, et al.
(författare)
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Differential locomotion of long- and short-term IL-2-activated murine natural killer cells in a model matrix environment.
- 2007
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Ingår i: Scandinavian journal of immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 66:4, s. 402-9
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Tidskriftsartikel (refereegranskat)abstract
- Tumour infiltration by activated natural killer (A-NK) cells is a pre-requisite for tumour eradication by adoptive NK cell transfer. Extravasated A-NK cells do not always succeed in reaching the crucial target cell conjugation. Therefore, we wished to study A-NK cell locomotion and interactions with melanoma cells in a matrix environment (Matrigel) by electron, confocal and fluorescence microscopy. Two distinct patterns of A-NK cell-mediated matrix disintegration were revealed during incubation of tumour cells and A-NK cells in Matrigel: (1) A-NK cells pre-cultured for 5 days altered the homogeneous texture of the Matrigel, an initial microporous appearance became a loose filamentous meshwork by 24 h. Matrix degrading protease inhibitors could not fully prevent this, but could delay the process; and (2) A-NK cells pre-cultured for 6 days or more, instead formed large excavations in the Matrigel leaving the remaining matrix less affected compared to the effects by the younger A-NK cells. By histochemical staining with Cupromeronic Blue, the excavations were shown to contain proteoglycan material. Protease inhibitors had no discernable effect on the development of the excavations. The conspicuous capacity of A-NK cells to disintegrate extracellular matrix and the formation of large excavations seems only partially to depend on matrix-degrading proteases. Formation of extracellular proteoglycan material is suggested to facilitate A-NK cell locomotion within a matrix environment.
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