| 1. |
- Comasco, Erika, 1982-, et al.
(författare)
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Genetic and Functional Study of L-Type Amino Acid Transporter 1 in Schizophrenia
- 2017
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Ingår i: Neuropsychobiology. - Basel : S. Karger. - 0302-282X .- 1423-0224. ; 74:2, s. 96-103
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia involves neural catecholaminergic dysregulation. Tyrosine is the precursor of catecholamines, and its major transporter, according to studies on fibroblasts, in the brain is the L-type amino acid transporter 1 (LAT1). The present study assessed haplotype tag single-nucleotide polymorphisms (SNPs) of the SLC7A5/LAT1 gene in 315 patients with psychosis within the schizophrenia spectrum and 233 healthy controls to investigate genetic vulnerability to the disorder as well as genetic relationships to homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the major catecholamine metabolites in the cerebrospinal fluid (CSF). Moreover, the involvement of the different isoforms of the system L in tyrosine uptake and LAT1 tyrosine kinetics were studied in fibroblast cell lines of 10 patients with schizophrenia and 10 healthy controls. The results provide suggestive evidence of individual vulnerability to schizophrenia related to the LAT1 SNP rs9936204 genotype. A number of SNPs were nominally associated with CSF HVA and MHPG concentrations but did not survive correction for multiple testing. The LAT1 isoform was confirmed as the major tyrosine transporter in patients with schizophrenia. However, the kinetic parameters (maximal transport capacity, affinity of the binding sites, and diffusion constant of tyrosine transport through the LAT1 isoform) did not differ between patients with schizophrenia and controls. The present genetic findings call for independent replication in larger samples, while the functional study seems to exclude a role of LAT1 in the aberrant transport of tyrosine in fibroblasts of patients with schizophrenia.
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| 2. |
- Furukawa, Toshi A., et al.
(författare)
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Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression : a systematic review and component network meta-analysis using individual data
- 2021
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Ingår i: Lancet psychiatry. - London, United Kingdom : Elsevier. - 2215-0374 .- 2215-0366. ; 8:6, s. 500-511
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Forskningsöversikt (refereegranskat)abstract
- Findings We identified 76 RCTs, including 48 trials contributing individual participant data (11 704 participants) and 28 trials with aggregate data (6474 participants). The participants' weighted mean age was 42.0 years and 12 406 (71%) of 17 521 reported were women. There was suggestive evidence that behavioural activation might be beneficial (iMD -1.83 [95% credible interval (CrI) -2.90 to -0.80]) and that relaxation might be harmful (1.20 [95% CrI 0.17 to 2.27]). Baseline severity emerged as the strongest prognostic factor for endpoint depression. Combining human and automated encouragement reduced dropouts from treatment (incremental odds ratio, 0.32 [95% CrI 0.13 to 0.93]). The risk of bias was low for the randomisation process, missing outcome data, or selection of reported results in most of the included studies, uncertain for deviation from intended interventions, and high for measurement of outcomes. There was moderate to high heterogeneity among the studies and their components. 511
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| 3. |
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| 4. |
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| 5. |
- Englund, Nina, et al.
(författare)
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Kunskapsglädje : En handbok om kompetensutveckling i sociala företag
- 2017
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Bok (populärvet., debatt m.m.)abstract
- Det här är en handbok för dig som vill arbeta med kompetensutveckling för personal i sociala företag. Den har tagits fram i samband med ett projekt som finansierats av Europeiska Socialfonden. Tillväxtverket har bidragit till bokens tryckning. Målet med projektet var att skapa en metod för kompetensutveckling av medarbetare inom sociala företag, men metoden fungerar också som inspiration för dig som vill utveckla din organisations sätt att arbeta med kompetensutveckling i vardagen. Tillsammans har forskare, pedagoger och sociala företag tagit fram metoden som fått namnet Kunskapsglädje.
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| 6. |
- Gaddefors, Johan, et al.
(författare)
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Rural entrepreneurship research : promoting reflexivity or functional stupidity?
- 2013
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Ingår i: Conference abstracts. - : University of West Scotland.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper departs from an ongoing interactive research project on entrepreneurial enclaves in southern Sweden aimed at promoting regional development through interaction between local stakeholders, academic researchers and undergraduate university students in three different municipalities. The logic of the project is that university students and academic researchers launch projects in the three municipalities. The projects are planned and performed with support from the local community. By initiating projects in the three municipalities, the research idea is that processes will start that can lead to new initiatives. Through initiating action and interaction the aim of the project is, in an experimental way, to see how entrepreneurship is mobilized. The question is how activities develop in the municipalities as a result of the research project, and how conflicts and resistance partake in this process.After having worked with the research project for half a year two issues surprised us; the conformity of the ideas in our three enclaves and the close relatedness, when it comes to practical solutions, between practice and academia. The research project seemed to have resulted in standardized, expected and widespread, common solutions to the kinds of problems and opportunities that are ascribed to the rural areas. As the solutions produced within the project are collaboratively discussed and decided upon by academic staff and local stakeholders, the fault of this lack of imagination seem to be a problem for all of us. Preconceptions about what is important in rural entrepreneurship guide us as researchers when we try to understand the field. Preconceptions were also a point of departure in the enclaves we studied, resulting in a few common solutions for how to cope with downturn and produce regional development. In this paper we are using the concept of functional stupidity (Alvesson & Spicer, 2012) to reflect upon the benefits as well as the drawbacks of the tendency, in the academy as well as in society at large, to produce a stereotypical menu of problems and suggested solutions when it comes to rural development. We also discuss the possibility to break this norm by promoting a kind of reflexivity that has the potential to produce surprising and norm-breaking ideas in the area of rural development.
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| 7. |
- Gaddefors, Johan, et al.
(författare)
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Staging rural entrepreneurship
- 2014
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Ingår i: Presented at the 12th Rural Entrepreneurship Conference, Harper Adams University, Shropshire, UK, June 18-19, 2014. ; , s. 1-16
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Gaddefors, Johan, et al.
(författare)
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Stepping up from the audience : the researcher as director and part of the ensemble
- 2013
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Ingår i: 22nd Nordic Academy of Management conference held at University of Iceland Reykjavík, 21-23 August, 2013. - : Nordic Academy of Management. ; , s. 73-73
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Adopting a theatrical metaphor, we argue that the engaged researcher can interact with the situation studied in three different research positions: as one of the directors staging an event (1), as a member of the ensemble performing an event (2), as a member of the audience observing an event (3). The three research positions identified are developed theoretically based on action research and interactive research. Those two affiliated methodological traditions have been developed out of the conviction that the neutral and distant research ideal is unrealistic and even problematic, as it holds out the prospect of a possible “view from nowhere” where the presence of the researcher does not influence the situation studied. We give examples from two research projects. In the first project a PhD student interacted within three different events using a specific research position in all three events, thus using all three positions within the same project. In the second project undergraduate students staged his/her project with local stake-holders, and researchers interchangeably staged events as well as took part of the ensemble performing the event and took part in certain events as part of the audience. Taking different roles as well as changing roles made the travel between closeness and distance to the research process possible as well as making sense of the studied processes in both projects. In the first project with a sole researcher extended time is necessary, while in the second project the different roles can be divided by members of the research ensemble.
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| 10. |
- Hu, Min, 1979-, et al.
(författare)
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Assessment of a Three-Dimensional Fiber Orientation Model for Timber
- 2016
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Ingår i: Wood and Fiber Science. - 0735-6161. ; 48:4, s. 271-290
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Tidskriftsartikel (refereegranskat)abstract
- Wood is an orthotropic material with very different properties along and across fibers, and every board has its own pattern of knots and fiber deviations. Therefore, detailed knowledge of the three-dimensional (3D) fiber orientation of individual boards would enable more accurate assessment of properties such as stiffness, strength, and shape stability. This paper presents a method for modeling 3D fiber orientation of side boards of Norway spruce. The method is based on dot laser scanning and utilization of the tracheid effect, and it is verified by a comparison between strain fields calculated on the basis of the fiber orientation model and corresponding strains determined using digital image correlation (DIC) technique. By means of the method, it is possible to identify knots and to reproduce the fiber orientation in clear wood in the vicinity of knots. Fiber orientation models of side boards including traversing edge knots were established and integrated in finite element models of boards used for simulation of four-point bending tests. The same boards were also tested in laboratory and displacement fields of the wide faces were recorded at different load levels using DIC technique. Comparisons of strain fields from measurements and simulations showed close agreement, regarding both strain patterns and strain levels. Local strain concentrations caused by very small defects were detected using the models and also found from the laboratory test results. The modeling approach may be used both to achieve improved accuracy of existing machine strength grading methods and, after further development, also for more advanced analysis of eg crack propagation and strength of timber.
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