| 1. |
- Hariz, Marwan I, et al.
(författare)
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Bilateral subthalamic nucleus stimulation in a parkinsonian patient with preoperative deficits in speech and cognition : persistent improvement in mobility but increased dependency
- 2000
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Ingår i: Movement Disorders. - 0885-3185 .- 1531-8257. ; 15:1, s. 136-139
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Tidskriftsartikel (refereegranskat)abstract
- We report a patient with advanced Parkinson's disease, including severe and frequent off periods with freezing of gait, moderate dysphonia, and some cognitive impairment, who underwent bilateral subthalamic nucleus (STN) stimulation. The patient was followed for 1 year after surgery, showing persistent good mobility without off periods and without freezing, which reverted completely when stopping the stimulation. There was deterioration of cognition as well as increased aphonia and drooling, all of which remained when the stimulation was turned off. The striking improvement in motor symptoms following STN stimulation was not paralleled by improvement in disability, probably as a result of a cognitive decline, suggesting a diagnosis of Parkinson's disease with dementia. We conclude that chronic STN stimulation is efficient in alleviating akinetic motor symptoms including gait freezing; this surgery should be offered before patients start to exhibit speech or cognitive disturbances.
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| 2. |
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| 3. |
- Helgeland, Øyvind, et al.
(författare)
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Characterization of the genetic architecture of infant and early childhood body mass index.
- 2022
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Ingår i: Nature metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 4:3
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Tidskriftsartikel (refereegranskat)abstract
- Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index at specific ages, matching different child growth phases, and representing four major trajectory patterns. We perform genome-wide association studies across 12 time points from birth to 8 years in 28,681 children and their parents (27,088 mothers and 26,239 fathers) in the Norwegian Mother, Father and Child Cohort Study. Monogenic obesity genes are overrepresented near identified loci, and several complex association signals near LEPR, GLP1R, PCSK1 and KLF14 point towards a major influence for common variation affecting the leptin-melanocortin system in early life, providing a link to putative treatment strategies. We also demonstrate how different polygenic risk scores transition from birth to adult profiles through early child growth. In conclusion, our results offer a fine-grained characterization of a changing genetic landscape sustaining early childhood growth.
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| 4. |
- Johansson, Kristina, et al.
(författare)
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Conditioned openings and restraints : The meaning‐making of women professionals breaking into the male‐dominated sector of forestry
- 2020
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Ingår i: Gender, Work and Organization. - : John Wiley & Sons. - 0968-6673 .- 1468-0432. ; 27:6, s. 927-943
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Tidskriftsartikel (refereegranskat)abstract
- This article addresses how women forestry professionals articulate and interpret their experiences of being a woman and a professional in the male‐dominated context of forestry. The findings suggest that the entrance of women into forestry has created openings as well as restraints within the dominant discourses of forestry organizations. Gendered constructions of skills and a workplace culture described as built on homosocial values cause women to feel questioned and disadvantaged. At the same time, women are valued for their perceived capacity to perform relational‐based aspects of forestry work and as a means to reduce gender segregation. We conclude that while these openings are conditioned by discourses of gender differences and masculine privileges, they provide women, to some extent, with subjectivity and organizational space that, with time, may challenge the dominant and gendered discourses of forestry organizations.
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| 5. |
- Johansson, Kristina, et al.
(författare)
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The Discursive Resistance of Men to Gender-equality Interventions : Negotiating “Unjustness”and “Unnecessity”in Swedish Forestry
- 2019
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Ingår i: Men and Masculinities. - : Sage Publications. - 1097-184X .- 1552-6828. ; 22:2, s. 177-196
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Tidskriftsartikel (refereegranskat)abstract
- This article adds to the understanding of men’s discursive resistance in relation to gender-equality interventions at work. Using Swedish men forestry professionals as the empirical base, the result shows how discursive resistance were performative acts, part of the construction of the same gender-equality interventions and organizational contexts that they were perceived to describe. In this case, direct opposition to gender equality provided a limited discursive position and sets of logics available in practice. Instead, the possibilities to renegotiate gender-equality interventions as unjust and unnecessary required, we conclude that the industry’s ambition to hire and promote more women was perceived to have led to the use of affirmative action and the disruption of meritocratic principles and that the problems of gender equality were placed in the traditional forestry and among “prejudiced old men,” as oppose to the more “modern” and “women friendly” forestry of today.
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| 6. |
- Johansson, Maria, et al.
(författare)
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Women forestry professionals meaning making of gender and gender equality
- 2015
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Konferensbidrag (refereegranskat)abstract
- In this paper we explore meaning makings of gender equality in forestry by drawing on a national survey of all women with an academic forestry education in Sweden. We analyse two open-ended questions concerning their experiences of being a woman in forestry and how gender equality in forestry could be improved. The aim is to investigate how these narratives construct norms and notions of "gender equality" in relation to forestry. We identify three dominant logics where gender equality is constructed: 1, in relation to women and concerning numerical representation. 2, as gendered power relations and organisational norms and culture. 3, as something distant from themself by emphasising that their position in the industry is motivated by competence rather than gender. While issues of gender equality has climbed the agenda of the men dominated Swedish forestry, little is known about how these initiatives are being received and understood among men and women working in forestry. On-going research on men forestry professional indicates that "being on of the lads" still constitutes a ticket into the masculine community of forestry, and by here focusing on women forestry professionals meaning making of gender and gender equality interventions at work, this study adds to critical studies of gender equality.
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| 7. |
- Witrant, Emmanuel, et al.
(författare)
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Predictive control over wireless multi-hop networks
- 2007
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Ingår i: Proceedings Of The 2007 Ieee Conference On Control Applications. - : IEEE. - 9781424404438 ; , s. 1037-1042
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Konferensbidrag (refereegranskat)abstract
- Remote control over wireless multi-hop networks is considered. Time-varying delays for the transmission of sensor and control data over the wireless network are caused by a randomized multi-hop routing protocol. The characterstics of the routing protocol together with lower-layer network mechanisms give rise to a delay process with high variance and stepwise changing mean. A new predictive control scheme with a delay estimator is proposed in the paper. The estimator is based on a Kalman filter with a change detection algorithm. It is able to track the delay mean changes but efficiently attenuate the high frequency jitter The control scheme is analyzed and its implementation detailed. Network data from an experimental setup are used to illustrate the efficiency of the approach.
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| 8. |
- Zackrisson, Björn, et al.
(författare)
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Mature results from a Swedish comparison study of conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma - The ARTSCAN trial
- 2015
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Ingår i: Radiotherapy and Oncology. - : Elsevier BV. - 0167-8140 .- 1879-0887. ; 117:1, s. 99-105
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: This report contains the mature five-year data from the Swedish ARTSCAN trial including information on the influence of p16 positivity (p16+) for oropharyngeal cancers. Material and methods: Patients with previously untreated squamous cell carcinoma without distant metastases of the oral cavity, oropharynx, larynx (except T1-2, NO glottic cancers) and hypopharynx were included. Patients were randomised between accelerated fractionation (AF) (1.1 Gy + 2 Gy per day, 5 days/week for 4.5 weeks, total dose 68 Gy) and conventional fractionation (CF) (2 Gy per day, 5 days/week for 7 weeks, total dose 68 Gy). Human papillomavirus (HPV)-associated p16-expression was assessed retrospectively in tumour tissues from patients with oropharyngeal carcinoma. Results: There was no significant difference in loco-regional control (LRC) between AF and CF (log-rank test p = 0.75). LRC at 5 years was 65.5% for AF and 64.9% for CF. Overall survival (OS) was similar in both arms (p = 0.99). The estimated cancer specific survival (CSS) at 5 years was 62.2% (AF) and 63.3% (CF) (p = 0.99). 206 specimens were analysed for p16 with 153 specimens (74%) identified as p16+. P16 status did not discriminate for response to AF vs. CF with regard to LRC, OS or CSS. Patients with p16+ tumours had a statistically significant better overall prognosis compared with p16 tumours. Conclusion: This update confirms the results of the 2-year report. We failed to identify a positive effect resulting from AF with regards to LRC, OS and CSS. The addition of information on the HPV-associated p16 overexpression did not explain this lack of effect.
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| 9. |
- Zackrisson, Björn, et al.
(författare)
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Two-year results from a Swedish study on conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma - The ARTSCAN study
- 2011
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Ingår i: Radiotherapy and Oncology. - : Elsevier. - 0167-8140 .- 1879-0887. ; 100:1, s. 41-48
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Tidskriftsartikel (refereegranskat)abstract
- Background and purpose: Studies on accelerated fractionation (AF) in head and neck cancer have shown increased local control and survival compared with conventional fractionation (CF), while others have been non-conclusive. In 1998 a national Swedish group decided to perform a randomised controlled clinical study of AF. Materials and methods: Patients with verified squamous cell carcinoma of the oral cavity, oropharynx, larynx (except glottic T1-T2, N0) and hypopharynx were included. Patients with prior chemotherapy or surgery were excluded. Patients were randomised to either CF (2Gy/day, 5days/week for 7 weeks, total dose 68Gy) or to AF (1.1Gy+2.0Gy/day, 5days/week for 4.5weeks, total dose 68Gy). An extensive quality assurance protocol was followed throughout the study. The primary end point was loco-regional tumour control (LRC) at two years after treatment. RESULTS: The study was closed in 2006 when 750 patients had been randomised. Eighty-three percent of the patients had stages III-IV disease. Forty eight percent had oropharyngeal, 21% laryngeal, 17% hypopharyngeal and 14% oral cancers. There were no significant differences regarding overall survival (OS) or LRC between the two regimens. The OS at two years was 68% for AF and 67% for CF. The corresponding figures for LRC were 71% and 67%, respectively. There was a trend towards improved LRC for oral cancers treated (p=0.07) and for large tumours (T3-T4) (p=0.07) treated with AF. The AF group had significantly worse acute reactions, while there was no significant increase in late effects. Conclusion: Overall the AF regimen did not prove to be more efficacious than CF. However, the trend towards improved results in AF for oral cancers needs to be further investigated.
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| 10. |
- Agnew, Louise, et al.
(författare)
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Factors associated with work ability in patients with chronic whiplash-associated disorder grade II-III : a cross-sectional analysis
- 2015
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Ingår i: Journal of Rehabilitation Medicine. - : FOUNDATION REHABILITATION INFORMATION. - 1650-1977 .- 1651-2081. ; 47:6, s. 546-551
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To investigate the factors related to self-perceived work ability in patients with chronic whiplash-associated disorder grades II-III.Design: Cross-sectional analysis.Patients: A total of 166 working age patients with chronic whiplash-associated disorder.Methods: A comprehensive survey collected data on work ability (using the Work Ability Index); demographic, psychosocial, personal, work- and condition-related factors. Forward, stepwise regression modelling was used to assess the factors related to work ability.Results: The proportion of patients in each work ability category were as follows: poor (12.7%); moderate (39.8%); good (38.5%); excellent (9%). Seven factors explained 65% (adjusted R-2 = 0.65, p < 0.01) of the variance in work ability. In descending order of strength of association, these factors are: greater neck disability due to pain; reduced self-rated health status and health-related quality of life; increased frequency of concentration problems; poor workplace satisfaction; lower self-efficacy for performing daily tasks; and greater work-related stress.Conclusion: Condition-specific and psychosocial factors are associated with self-perceived work ability of individuals with chronic whiplash-associated disorder.
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