| 1. |
- Sundström, Björn, 1968-, et al.
(författare)
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Cardiovascular risk factors among patients with ankylosing spondylitis in comparison to the general population
- 2013
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Ingår i: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 71:Suppl. 3
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Tidskriftsartikel (refereegranskat)abstract
- Background:An increased risk of cardiovascular diseases (CVD) has been reported among patients with Ankylosing Spondylitis (AS). As of today, little is known what causes this increase.Objectives: The aim of this study was to evaluate whether traditional CVD risk factors, such as smoking, diet, physical activity and atherogenic blood lipids, differ among AS patients in comparison to the general population.Methods: Eighty-nine patients diagnosed with AS by fulfilling the modified New York criteria were identified in the databases of a community intervention programme, the Västerbotten Intervention Programme (VIP). The patients were compared with 356 controls matched for age, sex and study period. As part of the VIP, participants have completed questionnaires regarding diet, physical activity and smoking. Additionally, the VIP included measurement of blood pressure, height and weight, and blood samples analysed for cholesterol, serum triglycerides and blood glucose.Results: Levels of serum triglycerides (p<0.01) and cholesterol (p<0.01) were significantly lower in the patient group. Among the patients, the level of triglycerides was inversely correlated to the intake of total fat (rs = -0.25, p<0.05), monounsaturated fats (rs = -0.29, p<0.05) and positively correlated to the intake of carbohydrates (rs =0.26, p<0.05). These correlations were not seen among the controls. No significant differences were found between patients and controls regarding diet, physical activity, exercise frequency or smoking habits nor in measurements of body mass index (BMI), weight or blood pressure.Conclusions: The patients exhibited significantly lower levels of cholesterol and triglycerides compared with controls. There were correlations between diet and atherogenic blood lipids among the patients which were not found in the control group. The results suggest that there may be differences in fat metabolism among patients with AS in comparison with the general population.
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| 2. |
- Sundström, Björn, et al.
(författare)
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Kost och andra kardiovaskulära riskfaktorer hos patienter med ankyloserande spondylit
- 2011
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Konferensbidrag (refereegranskat)abstract
- BakgrundHos patienter med ankyloserande spondylit (AS) har man sett en ökad förekomst av kardiovaskulära sjukdomar och det är inte klarlagt vad som orsakar denna ökning. Syftet med studien var därför att utvärdera om kost och andra kardiovaskulära riskfaktorer hos patienter med AS skiljer sig åt i jämförelse med normalbefolkningen. Metod Åttionio patienter med AS, diagnosticerade enligt de modifierade New York kriterierna, identifierades i databaserna till ett hälsoundersökningsprojekt, det så kallade Västerbotten Intervention Project (VIP). Patienterna jämfördes med 356 kontroller matchade för ålder, kön och undersökningsperiod. Inom VIP har deltagarna fyllt i enkäter om kost, fysisk aktivitet och rökning. Blodtryck, längd och vikt, har mätts och blodprover har analyserats för kolesterol, triglycerider och blodsockernivåer. Resultat Vi fann inga signifikanta skillnader mellan patienter och kontroller avseende kost, fysisk aktivitet, träningsvanor, rökvanor, BMI, vikt eller blodtryck. Däremot hade patienterna signifikant lägre nivåer av serumtriglycerider (p <0,001) och -kolesterol (p <0,01). Hos patienterna var triglyceridvärdet omvänt korrelerat till totala intaget av fett (rs = -0,25, p <0,05) liksom intaget av enkelomättade fetter (rs = -0,29, p <0,05) och positivt korrelerat till intaget av kolhydrater (rs = 0,26, p <0,05). Kolesterolvärdet visade också en positiv korrelation till intag av kolhydrater (rs = 0,26, p <0,05) och negativ korrelation till intaget av enkelomättade fetter (rs = -0,28, p <0,05). Dessa samband sågs inte hos kontrollerna. Sammanfattning Patienterna uppvisade signifikant lägre nivåer av kolesterol och triglycerider jämfört med kontrollgruppen. Det fanns samband mellan kost och aterogena blodfetter hos patienter som inte fanns i kontrollgruppen. Resultaten antyder att det kan finnas skillnader i fettmetabolismen hos patienter med AS i jämförelse med normalbefolkningen.
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| 3. |
- Sundström, Björn, 1968-, et al.
(författare)
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Modifiable cardiovascular risk factors in patients with ankylosing spondylitis
- 2014
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Ingår i: Clinical Rheumatology. - London : Springer London. - 0770-3198 .- 1434-9949. ; 33:1, s. 111-117
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the general population. Eighty-eight patients diagnosed with AS were identified by analysis of the databases of a previous community intervention programme, the Västerbotten intervention programme. The patients were compared with 351 controls matched for age, sex and study period. These databases include the results of blood samples analysed for cholesterol, triglycerides and plasma glucose, as well as data on hypertension, height, weight, smoking and dietary habits and physical activity. No significant differences were found between patients and controls regarding hypertension, body mass index, physical activity, diet or smoking. Levels of serum triglycerides (p < 0.01) and cholesterol (p < 0.01) were significantly lower in the patient group. Among the patients, the level of triglycerides correlated inversely with the intake of total fat (r s = −0.25, p < 0.05), monounsaturated fats (r s = −0.29, p < 0.05) and positively correlated to the intake of carbohydrates (r s = 0.26, p < 0.05). These associations were not apparent among the controls. In the cohort of AS patients studied, no differences were found regarding the modifiable risk factors for CVD compared with the general population. Hence, the increased presence of CVD in patients with AS may be caused by other factors such as differences in metabolism and medication such as NSAID or the chronic low-grade inflammation present in the disease.
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| 4. |
- Alm, Ilkoo, et al.
(författare)
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Cognitive aspects in visualisation of complex data
- 2001
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Ingår i: CISST'2001. - Avalon, Athens, USA : CSREA Press. - 1892512742 ; , s. 633-638
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Konferensbidrag (refereegranskat)abstract
- Information Visualization applications are dealing with fundamental difficulties related to overlap in cognitive models between designers and users, goal ambiguity, and accuracy in search strategies These difficulties are more obvious in applications aimed at reducing information overload by general users, than in applications aimed at visualising scientific data. General users have very likely quite different cognitive reference for approaching an abstract complex task, than designers. This can result in designs which can unintentionally increase information overload by users. In visualisation of scientific data the overlap of cognitive reference between specialists and designs is very likely much higher, but we need methods which can facilitate data exploration in real-time interaction. One possibility to facilitate exploration in a more or less systematic way is by means of metaphors which can support human perception in searching for patterns.
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| 5. |
- Pomares-Millan, Hugo, et al.
(författare)
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Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality
- 2022
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Ingår i: Nutrients. - Basel : MDPI. - 2072-6643. ; 14:15
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Tidskriftsartikel (refereegranskat)abstract
- People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person’s degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic disease later in life; we pooled data from two population-based Swedish prospective cohort studies (n = 53,507), and we contrasted an individual’s cardiometabolic biomarker profile with the profile predicted for them given their lifestyle exposure characteristics using a quantile random forest approach. People who were classed as ‘sensitive’ to hypertension- and dyslipidemia-related lifestyle exposures were at higher risk of developing cardiovascular disease (CVD, hazards ratio 1.6 (95% CI: 1.3, 1.91)), compared with the general population. No differences were observed for type 2 diabetes (T2D) risk. Here, we report a novel approach to identify individuals who are especially sensitive to adverse lifestyle exposures and who are at higher risk of subsequent cardiovascular events. Early preventive interventions may be needed in this subgroup.
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