| 1. |
- Alsterholm, Mikael, 1977, et al.
(författare)
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Establishment and utility of SwedAD : a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
- 2023
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 103
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Tidskriftsartikel (refereegranskat)abstract
- SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
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| 2. |
- Jimbo, Ryo, 1979, et al.
(författare)
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Protein adsorption to surface chemistry and crystal structure modification of titanium surfaces
- 2010
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Ingår i: Journal of Oral & Maxillofacial Research. - : Stilus Optimus. - 2029-283X. ; 1:3, s. e3-
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To observe the early adsorption of extracellular matrix and blood plasma proteins to magnesium-incorporated titanium oxide surfaces, which has shown superior bone response in animal models.Material and Methods: Commercially pure titanium discs were blasted with titanium dioxide (TiO2) particles (control), and for the test group, TiO2 blasted discs were further processed with a micro-arc oxidation method (test). Surface morphology was investigated by scanning electron microscopy, surface topography by optic interferometry, characterization by X-ray photoelectron spectroscopy (XPS), and by X-ray diffraction (XRD) analysis. The adsorption of 3 different proteins (fibronectin, albumin, and collagen type I) was investigated by an immunoblotting technique.Results: The test surface showed a porous structure, whereas the control surface showed a typical TiO2 blasted structure. XPS data revealed magnesium-incorporation to the anodic oxide film of the surface. There was no difference in surface roughness between the control and test surfaces. For the protein adsorption test, the amount of albumin was significantly higher on the control surface whereas the amount of fibronectin was significantly higher on the test surface. Although there was no significant difference, the test surface had a tendency to adsorb more collagen type I.Conclusions: The magnesium-incorporated anodized surface showed significantly higher fibronectin adsorption and lower albumin adsorption than the blasted surface. These results may be one of the reasons for the excellent bone response previously observed in animal studies.
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| 3. |
- Reikeras, O., et al.
(författare)
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Bone ingrowths to press-fit and loose-fit implants: comparisons between titanium and hydroxyapatite
- 2006
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Ingår i: J Long Term Eff Med Implants. - Boca Raton, Fl. : CRC Press. - 1050-6934 .- 1940-4379. ; 16:2, s. 157-64
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate whether the coating of titanium (Ti) implants with hydroxyapatite (HA) might create a better fixation when titanium implants are implanted into a gap. In each of 16 rats, the medullary cavity of both femurs was entered by an awl from the trochanteric area. With steel burrs it was successively reamed to a diameter of 1.5 mm. In a random manner the proximal part of the cavity in half of the bones was reamed once again to a diameter of 2.0 mm. Nails with a diameter of 1.5 mm and a length of 34 mm were then inserted into the medullary cavity of these bones with press fit at the distal half and a gap to the bone in the proximal half. In the remaining bones the whole medullary canal was reamed to a diameter of 2.0 mm, and nails with a diameter of 2.0 mm and a length of 34 mm were introduced. In all cases, either a pure Ti nail or a Ti nail entirely plasma sprayed with HA was used in a random manner. The surface roughness of the pure Ti was characterized by Ra 2.6 microm and Rt 22 microm. Ra of HA was 7.5 microm and Rt 52 microm. At sacrifice after 16 weeks, both femurs were dissected free from soft tissues and then immersed in fixative. A specimen slice of about 5 mm in thickness was prepared from the subtrochanteric region with a water-cooled band saw. Sample preparation for undecalcified tissue followed the internal guidelines at the laboratories of the Department of Biomaterials/Handicap Research. Generally, bone contact to the nails with HA coating was more predictable than was bone contact to the Ti nails. But due to rather large variations in bone contact between the samples, statistical analyses revealed non-significant differences between the 4 groups (p = 0.083). There were no significant differences between Ti and HA coated nails of 2.0 mm (p = 0.633), nor between Ti and HA coated nails of 1.5 mm (p = 0.924). The pooled values for the 2.0 mm nails showed significantly higher bone bonding contact than the pooled values of the 1.5 mm nails (p = 0.011). Our results, then, indicate that bone bonding contact to implants with a loose fit insertion is less predictable than in press fit insertion, and HA coating seemed to be more predictable than pure Ti. However, due to large variations between the samples, the differences did not reach significant levels.
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| 4. |
- Reikeras, O., et al.
(författare)
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Hydroxyapatite and carbon coatings for fixation of unloaded titanium implants
- 2004
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Ingår i: Journal of Long-Term Effects of Medical Implants. - 1050-6934 .- 1940-4379. ; 14:6, s. 443-454
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate the interaction between bone and pure titanium, titanium coated with hydroxyapatite (HA), and titanium coated with carbon in a rat femur model. In 25 rats, the medullary cavity of both femurs was entered by an awl from the trochanteric area. With steel burrs it was successively reamed to a diameter of 2.0 mm. Nails with a diameter of 2.0 mm and with a length of 34 mm were inserted in a random manner; either a pure titanium nail, a titanium nail entirely plasma-sprayed with a 75-100-microm layer of HA or a titanium nail coated with 2-10-microm carbon. The surface roughness of the pure titanium was characterized by Ra 2.6 microm and Rt 22 microm. Ra of HA was 7.5 microm and Rt 52 microm, and of carbon Ra was 0.4 microm and Rt 4.0 microm. Twelve rats were randomized to a follow up of 8 weeks, and the remaining 13 rats were followed for 16 weeks. At sacrifice both femora were dissected free from soft tissues and then immersed in fixative. A specimen slice of about 5 mm thickness was prepared from the subtrochanteric region with a water-cooled band-saw. Sample preparation for un-decalcified tissue followed the internal guidelines at the laboratories of Biomaterials/Handicap Research. At 8 weeks the median bone bonding contact of the implants was 43% (range 0-74) in the titanium group, 39% (0-75) in the HA group, and 3% (0-59) in the carbon group. At 16 weeks the corresponding figures were 58% (0-78) in the titanium group, 51% (15-75) in the HA group, and 8% (0-79) in the carbon group. In conclusion, we found great variability in bone bonding contact. In general, carbon-coated nails had reduced bone bonding contact both at 8 and at 16 weeks as compared to pure titanium or titanium coated with hydroxyapatite.
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| 5. |
- Reikeras, O., et al.
(författare)
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Hydroxyapatite enhances long-term fixation of titanium implants
- 2006
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Ingår i: J Long Term Eff Med Implants. - Boca Raton, FL : CRC Press. - 1050-6934 .- 1940-4379. ; 16:2, s. 165-73
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to evaluate osseous integration of hydroxyapatite coated titanium implants over time as compared to pure titanium. In 20 rats the medullary cavity of both femoral bones was entered by an awl from the trochanteric area. With steel burrs it was successively reamed to a diameter of 2.0 mm. Nails with a diameter of 2.0 mm and with a length of 34 mm were inserted into the medullary cavity; a pure titanium nail on the left side and a titanium nail entirely plasma-sprayed with hydroxyapatite (HA) on the right side. The surface roughness of the pure titanium was characterized by Ra 2.6 microm and Rt 22 microm, and HA had a roughness of Ra 7.5 (arithmetical mean roughness) microm and Rt (maximum profile height) 52 microm. The rats were randomized to a follow-up of 6 and 12 months, respectively. At sacrifice the femoral bones were dissected free from soft tissues. The bones were radiographed and then immersed in fixative. A specimen-slice of about 5 mm thickness was prepared from the region under the trochanter minor with a water cooled band-saw. Sample preparation for undecalcified tissue followed the internal guidelines at the laboratories of Biomaterials/Handicap Research. At 6 months the median bone bonding contact of the implants was 40% (range 0-92) in the titanium group and 34% (0-86) in the HA group. At 12 months the median bone bonding contact was 51% (0-97) in the titanium group and 86% (72-98) in the HA group. In conclusion, we found a significant (p = 0.001) increase in bone bonding contact from 6 to 12 months of the HA coated nails and significantly (p = 0.043) enhanced bone bonding contact in HA coated nails at 12 months as compared to pure titanium nails.
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| 6. |
- Sigurdardottir, Gunnthorunn, et al.
(författare)
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Cross-Cultural Validation of the RECAP of Atopic Eczema Question-naire in a Swedish Population
- 2024
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden. - 0001-5555 .- 1651-2057. ; 104
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Tidskriftsartikel (refereegranskat)abstract
- A Swedish translation of the patient-reported outcome measure for assessing long-term control of atopic dermatitis, Recap of atopic eczema (RECAP), has not been validated. Cross-cultural translation and multi-centre validation of the translated RECAP questionnaire were therefore performed. Disease severity was assessed using the validated Investigator Global Assessment Scale for atopic dermatitis (vIGA-ADTM). The Swedish RECAP was completed by 208 individuals aged 16 years or older with a median age of 36 years (interquartile range [IQR] 27-48). The participants considered the questionnaire suitable for assessing eczema control. The median RECAP score (range 0-28) was 12 (IQR 5-19). The mean and median vIGA-ADTM scores (range 0-4) were 2 (standard deviation [SD] 2) and 3 (IQR 2-4), respectively. A correlation between RECAP and the vIGA-ADTM was observed (p < 0.001). There was no significant change in scores for participants who answered the questionnaire twice within 14 days. Over time, improved or worsened eczema, as evaluat-ed by vIGA-ADTM, affected RECAP scores significantly (p < 0.001). The study suggests that RECAP can assess AD control in a Swedish clinical setting and shows -acceptable reliability.
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| 7. |
- Sundfeldt, Mikael, 1962, et al.
(författare)
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Aseptic loosening, not only a question of wear: a review of different theories
- 2006
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Ingår i: Acta Orthopaedica. - : Medical Journals Sweden AB. - 1745-3674 .- 1745-3682. ; 77:2, s. 177-97
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Tidskriftsartikel (refereegranskat)abstract
- Today, aseptic loosening is the most common cause of revision of major arthroplasties. Aseptic loosening accounts for more than two-thirds of hip revisions and almost one-half of knee revisions in Sweden. Several theories on the cause of aseptic loosening have been proposed. Most of these theories, however, are based on empiric observations, experimental animal models or anecdotal cases. In this review, we discuss the most common theories concerning aseptic loosening. It emerges from this review that aseptic loosening has a multifactorial etiology and cannot be explained by a single theory.
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| 8. |
- Sundfeldt, Mikael, et al.
(författare)
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Long-term results of a cementless knee prosthesis with a metal-backed patellar component : clinical and radiological follow-up with histology from retrieved components
- 2003
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Ingår i: Journal of long-term effects of medical implants. - 1050-6934 .- 1940-4379. ; 13:4, s. 341-354
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Tidskriftsartikel (refereegranskat)abstract
- Aseptic loosening of cemented knee arthroplasties has encouraged development of uncemented fixation. The Miller-Galante I (MG I) prosthesis was designed to achieve permanent stability through ingrowth into a titanium fiber mesh. Thirty-five knees in 30 patients with MG I knee replacements have been followed clinically and radiologically with a mean follow-up of 12 years. Twenty knees were revised with a mean follow-up of 5 years. Patellofemoral problems, especially avulsion of the polyethylene from the metal-backed patella and in some cases severe metallosis, have been the main reason for revision. Metal-backed patellar component should be avoided. In addition, instability has been a problem. However, the fixation of the components has been excellent, with a high degree of osseous ingrowth displayed at histological analysis of retrieved components. The clinical and radiological results after revision are in most cases good, despite the femoral component having been left in situ.
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