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- Backius, Stefan
(författare)
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Arbetare på scen : amatörteater som politiskt verktyg
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis focuses on the political dimensions of aesthetic expression during the Long Sixties. The thesis deals with amateur theatre ventures both within and linked to the social democratic labour movement. ’Spelet om Norbergsstrejken’ (The Play about the Norberg Strike) had its première in 1977 in a small industrial village in the industrial region of Bergslagen. Similar plays appeared in many regions of the country and a wave of workers’ plays emerged and made an impact on the internal investments of the educational association ABF in amateur theatre. The empiricism of the thesis concludes in 1982 when a social democratic amateur theatre association was founded and after a breakaway from the social democratic movement was establishing a residential study centre in another small village in Bergslagen. Sixties radicalisation provides the social context of the study and the perspective of sociological social movement research is used and developed. Based on the perspective of cognitive practice and the concepts of cosmology and movement ideology attention is directed towards the theatre assets of performance hosts, expectation horizons and patterns of behaviour. The thesis argues for a deeper understanding of sixties radicalisation partly meaning that the periodisation needs to be extended backwards as well as forwards in terms of time and partly that the political dimensions of aesthetic expression should be focused on. Based upon the results of the thesis the concept of culturactivism was formulated which defines the specific approach that appeared in the space between political and cultural activism. This highlights the need for a concept that covers the cognitive free space that arose between aesthetic expression and political activism and which has not previously attracted the attention of historical studies about sixties radicalisation to any great degree.
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| 2. |
- Johansson, Emma M., et al.
(författare)
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Quantitative analysis of exudates from soil-living basidiomycetes in pure culture as a response to lead, cadmium and arsenic stress
- 2008
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Ingår i: Soil Biology and Biochemistry. - Amsterdam : Elsevier. - 0038-0717 .- 1879-3428. ; 40:9, s. 2225-2236
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Tidskriftsartikel (refereegranskat)abstract
- Six different ectomycorrhizal fungi (Hebeloma velutipes, Piloderma byssinum, Paxillus involutus, Rhizopogonroseolus, Suillus bovinus and Suillus variegatus) and two saprotrophic fungi (Hypholoma fasciculare andHypholoma capnoides) were exposed to metal stress induced by Pb, Cd and As. After pre-growth ina nutrient solution in Petri dishes, metal exposure was performed either in a nutrient rich solution or ina nutrient poor solution for seven days. The fungi were exposed to two different metal concentrations,low and high (Pb: 10 þ 100 mM; Cd: 1 þ 10 mM; As: 1 þ 10 mM). Exudation of low molecular weightorganic compounds (low molecular weight organic acids (LMWOA), amino acids and dissolved monosaccharides),as well as dissolved organic carbon was quantified as a potential response to the metalstress. The main LMWOA identified was oxalate. Oxalate exudation increased significantly in response toboth low and high Pb and Cd concentrations, as well as low As exposure, relative to nutrient controls.Exposure to As and mixtures of metals (Pb þ Cd, Pb þ As) did not result in any significant increase inoxalate production compared to controls. The presence of a carbon source (glucose) in this study islikely to have been important for exudation of organic compounds. For the nutrient rich (þ1mMglucose) metal treatments exposure to Pb and Cd mainly increased exudation of oxalate and total aminoacids. Production of dissolved monosaccharides, as well as DOC, did not increase significantly in responseto metal exposure, irrespective of nutrient conditions. This may be explained by re-absorption ofthe organic compounds by the mycelium or by the fact that metals had no effect on exudation of thesecompounds.
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| 3. |
- Johansson, Emma M., et al.
(författare)
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Quantitative analysis of root and ectomycorrhizal exudates as a response to Pb, Cd and As stress
- 2008
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Ingår i: Plant and Soil. - Berlin : Springer. - 0032-079X .- 1573-5036. ; 313:1-2, s. 39-54
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Tidskriftsartikel (refereegranskat)abstract
- We examined exudation of low molecular weight (LMW) organic compounds of ectomycorrhizal (ECM) and non-mycorrhizal (NM) seedlings in relation to metals. Scots pine seedlings, either colonized by one of six different ECM fungi or NM, were grown in Petri dishes containing glass beads and liquid growth medium and exposed to elevated concentrations of Pb, Cd and As. Exudation of LMW organic compounds (LMW organic acids (LMWOAs), amino acids and dissolved monosaccharides) and dissolved organic carbon (DOC) was determined qualitatively and quantitatively and exudation rates were calculated. Metals had a significant impact on exudation, especially of oxalate. For Pb and Cd treatments, exudation of oxalate and total LMWOAs generally increased by 15–45% compared to nutrient controls. Production of amino acids, dissolved monosaccharides and DOC was not significantly stimulated by exposure to metals; however, there were non-significant trends towards increased exudation. Finally, exudation generally increased in the presence of mycorrhizal seedlings compared to NM seedlings. The results suggest that ECM fungi may reduce the toxicity of metals to plants through significant increases in the production of organic chelators. Axenic conditions are required to assess the full potential for production of these molecules but their overall significance in soil ecosystems needs to be determined using additional experiments under more ecologically realistic conditions.
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| 4. |
- Johansson, Emma M., et al.
(författare)
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Quantitative analysis of soluble exudates produced by ectomycorrhizal roots as a response to ambient and elevated CO2
- 2009
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Ingår i: Soil Biology and Biochemistry. - Amsterdam : Elsevier. - 0038-0717 .- 1879-3428. ; 41:6, s. 1111-1116
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Tidskriftsartikel (refereegranskat)abstract
- Despite its potential impact on soil carbon flow, few studies have attempted to quantify the effects of elevated carbon dioxide (CO2) on production of exudates by mycorrhizal plants. In this study we quantified low molecular weight (LMW) organic compounds exuded by non-mycorrhizal (NM) and ectomycorrhizal (ECM) plants in relation to exposure to elevated CO2. Scots pine seedlings, either colonized by one of eight different ECM fungi or non-mycorrhizal (NM), were exposed to either ambient (350 ppm) or elevated (700 ppm) concentrations of CO2. Exudation of LMW organic acids (LMWOAs), amino acids, dissolved monosaccharides and total dissolved organic carbon (DOC) was determined and exudation rates were calculated per g root and fungal dry mass. CO2 had a significant impact on exudation. Under elevated CO2, exudation of total LMWOAs increased by 120–160%, amino acids by 250%, dissolved monosaccharides by 130–270% and DOC by 180–220% compared to ambient CO2 treatment. Net CO2 assimilation rates increased significantly by 41–47% for seedlings exposed to elevated CO2. Exuded C calculated as a percentage of assimilated CO2 increased by 41–88% in the elevated CO2 treatment compared to ambient CO2 treatment.
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| 5. |
- Mulligan, Stephen P, et al.
(författare)
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Cladribine prolongs progression-free survival and time to second treatment compared to fludarabine and high-dose chlorambucil in chronic lymphocytic leukemia
- 2014
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Ingår i: Leukemia and Lymphoma. - : Informa Healthcare. - 1042-8194 .- 1029-2403. ; 55:12, s. 2769-2777
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a randomized phase III trial to compare the efficacy and safety of two purine analogs, cladribine and fludarabine, with high-dose chlorambucil, in patients with previously untreated chronic lymphocytic leukemia (CLL). Between 1997 and 2004, 223 patients with CLL were randomly assigned to cladribine, fludarabine or chlorambucil, for six cycles of therapy with frequent health-related quality of life assessments. There was no statistical difference for the primary endpoint of overall response with cladribine (70%), fludarabine (67%) and chlorambucil (59%), or complete remission (12%, 7% and 8%), respectively. However, the median progression-free survival (25, 10, 9 months) and median time to second treatment (40, 22, 21 months) were superior with cladribine. There was no significant difference in overall survival (96, 82 and 91 months), nor in toxicity or HRQoL assessments. Monotherapy with cladribine gives superior PFS and longer response duration than fludarabine and chlorambucil as first-line treatment of CLL.
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| 6. |
- Panican, Alexandru, et al.
(författare)
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Rådgivare, vägledare och mäklare – om grundskolans roll och betydelse för gymnasievalet
- 2014
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Ingår i: Vetenskapliga perspektiv på lärande, undervisning och utbildning i olika institutionella sammanhang – utbildningsvetenskaplig forskning vid Lunds universitet. - Helsingborg : Institutionen för utbildningsvetenskap, Lunds universitet. - 9789174738629 ; , s. 177-194
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Bokkapitel (refereegranskat)abstract
- I en kontext av en generellt ökande välfärdspluralism där medborgaren ställs inför betydligt fler val än tidigare, har det nyliberala tänkesättet också fått ett stort genomslag i det svenska utbildningssystemet. På skolområdet, som traditionellt dominerats av offentliga huvudmän, ser vi idag en blandning mellan offentliga och privata aktörer. Denna utveckling får som konsekvens att såväl de som är verksamma inom utbildningssystemet som elever och deras föräldrar behöver hitta nya förhållningssätt. För de yrkesverksamma innebär ökad konkurrens att de befinner sig i en verksamhet som antar rollen som marknadsaktör där elever och deras föräldrar alltmer blir betraktade som kunder. Utbildningssystemet har skapat lokala skolmarknader. Elever och deras föräldrar åtnjuter ökade valmöjligheter men får samtidigt krav på sig att sätta sig in i och värdera olika alternativ. Ett tydligt exempel på avreglering och marknadsanpassning i utbildningssystemet utgörs av gymnasievalet. I detta kapitel uppmärksammas den period som föregår gymnasiestudier då grundskoleelever med stöd från skolpersonal måste välja den fortsatta studievägen på sekundär nivå. Vi inriktar oss på gymnasieval genom att analysera vad ökade valmöjligheter kan innebära för representanter för grundskolan i förhållande till elevernas gymnasieval. Vi kommer att fokusera på hur rektorer och studie- och yrkesvägledare reflekterar kring sin roll utifrån de förändringar som skett gällande gymnasievalet. Övergripande pekar svaren att inslaget av informationsförmedling har intensifierats samtidigt som många elever behöver ett mer handfast och omfattande stöd i att förhålla sig till valet. Det finns en osäkerhet i hur skolrepresentanter ska förhålla sig till gymnasievalet. Den tidigare rollen som informatör utmanas av nya krav, förväntningar och dilemman vilket leder till att skolrepresentanter kan ta på sig rollen som rådgivare, vägledare eller mäklare för att matcha elevens preferenser och förutsättningar med det komplexa utbud av program, inriktningar och skolor som erbjuds.
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| 7. |
- Tran, Pham Tue Hung, 1991-, et al.
(författare)
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Identification and characterization of host proteins inducing the endoplasmic reticulum invagination during Flavivirus infection
- 2019
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Ingår i: Positive-Strand RNA Viuses. ; , s. 280-280
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Konferensbidrag (refereegranskat)abstract
- When Flaviviruses infect host cells, they can induce invagination of endoplasmic reticulum (ER) membrane to form vesicle-like compartments. These unique structures are hypothetical to facilitate the viral replication by reducing diffusion of virus replication machinery and viral RNA, providing a scaffold to anchor the replication complex, and protecting viral RNA from host cell intrinsic surveillance. The rearrangements of ER membrane to form these replication compartments (RCs) require modifications in its lipid constituents or binding of proteins to the membrane. Flaviviruses, indeed, use their proteins to generate RCs. It has been implicated that both KUNV and DENV viral NS1, NS2A, NS4A, NS4B proteins could induce membrane remodelings. However, it is recondite whether host proteins can also participate in the formation and maintenance of RCs.In this project, we aimed to identify and characterize of host proteins inducing RC generation during Flavivirus infections. We used A549 as a cell model, and mosquito-borne Zika and Kunjin virus, and tick-borne Langat virus as virus models. After virus infections, ER membranes were harvested using ultracentrifuge with a sucrose gradient. Proteins from these ERs were identified using mass spectrometry. We compared the differences between the ER proteomes of infected cells and non-infected cells to identify host candidate proteins that can cause the RC formation. We are attempting to enrich the RC-containing fractions and identifying proteins here, which narrows the list of true candidate proteins. The candidate proteins then will be characterized by using molecular techniques such as gene knock down, overexpression, and microscopy techniques.
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| 8. |
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| 9. |
- Tran, Pham Tue Hung, 1991-, et al.
(författare)
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Screening of host proteins interacting with Kunjin, Langat, Zika replication complex
- 2019
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Ingår i: Positive-Strand Rna Viuses.
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Konferensbidrag (refereegranskat)abstract
- When Flaviviruses infect host cells, they can induce invagination of endoplasmic reticulum (ER) membrane to form vesicle-like compartments. These unique structures are hypothetical to facilitate the viral replication by reducing diffusion of virus replication machinery and viral RNA, providing a scaffold to anchor the replication complex, and protecting viral RNA from host cell intrinsic surveillance. The rearrangements of ER membrane to form these replication compartments (RCs) require modifications in its lipid constituents or binding of proteins to the membrane. Flaviviruses, indeed, use their proteins to generate RCs. It has been implicated that both KUNV and DENV viral NS1, NS2A, NS4A, NS4B proteins could induce membrane remodelings. However, it is recondite whether host proteins can also participate in the formation and maintenance of RCs.In this project, we aimed to identify and characterize of host proteins inducing RC generation during Flavivirus infections. We used A549 as a cell model, and mosquito-borne Zika and Kunjin virus, and tick-borne Langat virus as virus models. After virus infections, ER membranes were harvested using ultracentrifuge with a sucrose gradient. Proteins from these ERs were identified using mass spectrometry. We compared the differences between the ER proteomes of infected cells and non-infected cells to identify host candidate proteins that can cause the RC formation. We are attempting to enrich the RC-containing fractions and identifying proteins here, which narrows the list of true candidate proteins. The candidate proteins then will be characterized by using molecular techniques such as gene knock down, overexpression, and microscopy techniques.
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| 10. |
- Tran, Pham Tue Hung, 1991-, et al.
(författare)
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Screening of host proteins interacting with Kunjin, Langat, Zikareplication complex
- 2019
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Ingår i: 16th Smögen Summer Symposium on Virology.
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Konferensbidrag (refereegranskat)abstract
- During infection and eclipse time, Flaviviruses induce invagination of the endoplasmic reticulum (ER) membrane to form compartments, protecting their viral replication complex. The rearrangements of ER membrane require modifications in ER membrane lipid constituents or binding of proteins to bend the membrane. Indeed, it has been implicated that both KUNV and DENV NS1, NS2A, NS4A, NS4B proteins could induce membrane remodelings. However, it is not well known whether host proteins can also participate in the formation and maintenance of these compartments.In this project, we aimed to identify host proteins interacting with Kunjin, Langat, Zika replication complex. These proteins may function for ER invagination during Flavivirus infection. We used human adenocarcinoma epithelial A549 cells as a cell model, mosquito-borne Zika, Kunjin virus, and tick-borne Langat virus as virus models. After virus infections, the ER membranes from infected and non-infected cells were harvested using ultracentrifuge with a sucrose gradient. Proteins from these ERs were identified using mass spectrometry. We compared the differences between the ER proteomes to identify host candidate proteins that can cause the RC formation. To narrows the list of true candidate proteins, we attempted to enrich the RC-containing fractions by doing co-immuno precipitation. We are doing TMT-MS to identify and quantify the host proteins from Co-IP elutions. The functions of these proteins will be characterized by using molecular techniques.
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