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- Amundadottir, Laufey T., et al.
(författare)
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A common variant associated with prostate cancer in European and African populations
- 2006
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Ingår i: Nature Genetics. - DeCODE Genet, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Pathol, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Urol, IS-101 Reykjavik, Iceland. Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA. Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 38:6, s. 652-658
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Tidskriftsartikel (refereegranskat)abstract
- With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
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| 2. |
- Johansson, Bjarne, et al.
(författare)
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Kubernetes Orchestration of High Availability Distributed Control Systems
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Distributed control systems transform with the Industry 4.0 paradigm shift. A mesh-like, network-centric topologyreplaces the traditional controller-centered architecture, enforcing the interest of cloud-, fog-, and edge-computing, where lightweight container-based virtualization is a cornerstone. Kubernetes is a well-known container management system for container orchestration in cloud computing. It is gaining traction inedge- and fog-computing due to its elasticity and failure recovery properties. Orchestrator failure recovery can complement the manual replacement of a failed controller and, combined with controller redundancy, provide a pseudo-one-out-of-many redundancy. This paper investigates the failure recovery performance obtained from an out-of-the-box Kubernetes installation in a distributed control system scenario. We describe a Kubernetes based virtualized controller architecture and the software needed to setup a bare-metal cluster for control systems. Further, we deploy single and redundant configured containerized controllers based on an OPC UA compatible industry middleware software on the bare-metal cluster. The controllers expose variables with OPCUA PubSub. A script-based daemon introduces node failures, and a verification controller measures the downtime when using Kubernetes with an industry redundancy solution
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| 3. |
- Kristensen, Dorte V, et al.
(författare)
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Characteristics of communication with older people in home care : A qualitative analysis of audio recordings of home care visits.
- 2017
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Ingår i: Journal of Clinical Nursing. - : Wiley. - 0962-1067 .- 1365-2702. ; 26:23-24, s. 4613-4621
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Tidskriftsartikel (refereegranskat)abstract
- AIMS AND OBJECTIVES: To describe the characteristics of communication practice in home care visits between older people (over 65 years old) and nurse assistants and to discuss the findings from a person-centered perspective.BACKGROUND: The older population is increasing worldwide, along with the need for healthcare services in the person's home. To achieve a high-quality care, person-centered communication is crucial.DESIGN: A descriptive design with a qualitative inductive approach was used.METHOD: Fifteen audio recordings of naturally occurring conversations between 12 nurse assistants and 13 older people in Norway were analysed by qualitative content analysis.RESULTS: Four categories were revealed through analysis: (i) supporting older people's connection to everyday life; (ii) supporting older people's involvement in their own care; (iii) attention to older people's bodily and existential needs; and (iv) the impact of continuity and predictability on older people's well-being.CONCLUSIONS: The communication between the older people and the nurse assistants during home care visits was mainly task-oriented, but also related to the person. The older people were involved in the tasks to be carried out and humour was part of the communication. Greater attention was paid to bodily than existential needs. The communication was connected with the older people's everyday life in several ways. Time frames and interruptions concern the older people; hearing and speech impairments were a challenge to communication. To enhance person-centred communication, further studies are needed, especially intervention studies for healthcare professionals and students.RELEVANCE TO CLINICAL PRACTICE: Being responsive to older people's subjective experiences is important in meeting their needs in home care. Communication that addresses the need for trust and predictability is important for older people. Responding to existential needs require more attention. The home care setting has an impact on communication.
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