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Träfflista för sökning "WFRF:(Johansson V.) srt2:(2010-2014);srt2:(2010);lar1:(umu)"

Search: WFRF:(Johansson V.) > (2010-2014) > (2010) > Umeå University

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1.
  • Carey, V, et al. (author)
  • Blockwise adaptivity for time dependent problems based on coarse scale adjoint solutions
  • 2010
  • In: SIAM Journal on Scientific Computing. - : Society for Industrial and Applied Mathematics. - 1064-8275 .- 1095-7197. ; 32:4, s. 2121-2145
  • Journal article (peer-reviewed)abstract
    • We describe and test an adaptive algorithm for evolution problems that employs a sequence of "blocks" consisting of fixed, though non-uniform, space meshes. This approach offers the advantages of adaptive mesh refinement but with reduced overhead costs associated with load balancing, re-meshing, matrix reassembly, and the solution of adjoint problems used to estimate discretization error and the effects of mesh changes. A major issue whith a blockadaptive approach is determining block discretizations from coarse scale solution information that achieve the desired accuracy. We describe several strategies to achieve this goal using adjoint-based a posteriori error estimates and we demonstrate the behavior of the proposed algorithms as well as several technical issues in a set of examples.
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4.
  • Stacey, Simon N, et al. (author)
  • Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.
  • 2010
  • In: PLoS genetics. - : Public Library of Science. - 1553-7404. ; 6:7, s. e1001029-
  • Journal article (peer-reviewed)abstract
    • We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls. We found that rs2046210[T] does not confer substantial risk of breast cancer in Europeans and Africans (OR = 1.04, P = 0.099, and OR = 0.98, P = 0.77, respectively). Rather, in those ancestries, an association signal arises from a group of less common SNPs typified by rs9397435. The rs9397435[G] allele was found to confer risk of breast cancer in European (OR = 1.15, P = 1.2 x 10(-3)), African (OR = 1.35, P = 0.014), and Asian (OR = 1.23, P = 2.9 x 10(-4)) population samples. Combined over all ancestries, the OR was 1.19 (P = 3.9 x 10(-7)), was without significant heterogeneity between ancestries (P(het) = 0.36) and the SNP fully accounted for the association signal in each ancestry. Haplotypes bearing rs9397435[G] are well tagged by rs2046210[T] only in Asians. The rs9397435[G] allele showed associations with both estrogen receptor positive and estrogen receptor negative breast cancer. Using early-draft data from the 1,000 Genomes project, we found that the risk allele of a novel SNP (rs77275268), which is closely correlated with rs9397435, disrupts a partially methylated CpG sequence within a known CTCF binding site. These studies demonstrate that shifting the analysis among ancestral populations can provide valuable resolution in association mapping.
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  • Result 1-4 of 4

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