| 1. |
- Muggerud, Aslaug Aamodt, et al.
(författare)
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Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
- 2010
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Ingår i: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 4:4, s. 357-368
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Tidskriftsartikel (refereegranskat)abstract
- Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer where cells restricted to the ducts exhibit an atypical phenotype. Some DCIS lesions are believed to rapidly transit to invasive ductal carcinomas (IDCs), while others remain unchanged. Existing classification systems for DCIS fail to identify those lesions that transit to IDC. We studied gene expression patterns of 31 pure DCIS, 36 pure invasive cancers and 42 cases of mixed diagnosis (invasive cancer with an in situ component) using Agilent Whole Human Genome Oligo Microarrays 44k. Six normal breast tissue samples were also included as controls. qRT-PCR was used for validation. All DCIS and invasive samples could be classified into the "intrinsic" molecular subtypes defined for invasive breast cancer. Hierarchical clustering establishes that samples group by intrinsic subtype, and not by diagnosis. We observed heterogeneity in the transcriptomes among DOS of high histological grade and identified a distinct subgroup containing seven of the 31 DCIS samples with gene expression characteristics more similar to advanced tumours. A set of genes independent of grade, ER-status and HER2-status was identified by logistic regression that univariately classified a sample as belonging to this distinct DCIS subgroup. qRT-PCR of single markers clearly separated this DCIS subgroup from the other DCIS, and contains samples from several histopathological and intrinsic molecular subtypes. The genes that differentiate between these two types of DCIS suggest several processes related to the re-organisation of the microenvironment. This raises interesting possibilities for identification of DCIS lesions both with and without invasive characteristics, which potentially could be used in clinical assessment of a woman's risk of progression, and lead to improved management that would avoid the current over- and under-treatment of patients.
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| 2. |
- Nordgarden, Hilde, et al.
(författare)
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Are Botulinum Toxin Injections Into the Major Salivary Glands a Good Treatment Option?
- 2012
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Ingår i: Journal of Child Neurology. - : Sage Publications. - 0883-0738 .- 1708-8283. ; 27:4, s. 458-464
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Tidskriftsartikel (refereegranskat)abstract
- There are several treatment options available for drooling; botulinum toxin injections into the major salivary glands are one. There is no consensus as to how many and which glands should be injected. A research project on this topic was terminated because of adverse effects. Individual results and the adverse effects are described and discussed in this article. Six individuals with cerebral palsy were randomly allocated to 2 treatment groups, with five individuals receiving ultrasound-guided injections to parotid and submandibular glands and one receiving injections to the submandibular glands only. Reduction of observed drooling was registered in 3, while 4 patients reported subjective improvement (Visual Analog Scale). Two participants reported adverse effects, including dysphagia, dysarthria, and increased salivary viscosity. Injections with botulinum toxin can be a useful treatment option but there is a risk of adverse effects. Multidisciplinary evaluation and informed discussions with patients/caregivers are important factors in the decision-making process.
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| 3. |
- Smith-Johnsen, Christine, et al.
(författare)
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Direct and indirect electron precipitation effect on nitric oxide in the polar middle atmosphere, using a full-range energy spectrum
- 2017
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 122:8, s. 8679-8693
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Tidskriftsartikel (refereegranskat)abstract
- In April 2010, a coronal mass ejection and a corotating interaction region on the Sun resulted in an energetic electron precipitation event in the Earth’s atmosphere. We investigate direct and indirect nitric oxide (NO) response to the electron precipitation. By combining electron fluxes from the Total Energy Detector and the Medium Energy Proton and Electron Detector on the National Oceanic and Atmospheric Administration’s Polar-orbiting Operational Environmental Satellites, we obtain a continuous energy spectrum covering 1–750 keV. This corresponds to electrons depositing their energy at atmospheric altitudes 60–120 km. Based on the electron energy deposition, taking into account loss due to photolysis, the accumulated NO number density is estimated. When compared to NO measured at these altitudes by the Solar Occultation for Ice Experiment instrument on board the Aeronomy of Ice in the Mesosphere satellite, the NO direct effect was detected down to 55 km. The main variability at these altitudes is, however, dominated by the indirect effect, which is downward transported NO. We estimate the source of this descending NO to be in the upper mesosphere at ~75–90 km.
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| 4. |
- Smith-Johnsen, Christine, et al.
(författare)
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Nitric Oxide Response to the April 2010 Electron Precipitation Event : Using WACCM and WACCM-D With and Without Medium-Energy Electrons
- 2018
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Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 123:6, s. 5232-5245
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Tidskriftsartikel (refereegranskat)abstract
- Energetic electrons from the magnetosphere deposit their energy in the atmosphere and lead to production of nitric oxide (NO) in the mesosphere and lower thermosphere. We study the atmospheric NO response to a geomagnetic storm in April 2010 with WACCM (Whole Atmosphere Community Climate Model). Modeled NO is compared to observations by Solar Occultation For Ice Experiment/Aeronomy of Ice in the Mesosphere at 72-82 degrees S latitudes. We investigate the modeled NOs sensitivity to changes in energy and chemistry. The electron energy model input is either a parameterization of auroral electrons or a full range energy spectrum (1-750keV) from National Oceanic and Atmospheric Administration/Polar Orbiting Environmental Satellites and European Organisation for the Exploitation of Meteorological Satellites/Meteorological Operational satellites. To study the importance of ion chemistry for the production of NO, WACCM-D, which has more complex ion chemistry, is used. Both standard WACCM and WACCM-D underestimate the storm time NO increase in the main production region (90-110km), using both electron energy inputs. At and below 80km, including medium-energy electrons (>30keV) is important both for NO directly produced at this altitude region and for NO transported from other regions (indirect effect). By using WACCM-D the direct NO production is improved, while the indirect effects on NO suffer from the downward propagating deficiency above. In conclusion, both a full range energy spectrum and ion chemistry is needed throughout the mesosphere and lower thermosphere region to increase the direct and indirect contribution from electrons on NO.
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