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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk

Lindehammer, Sabina (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Dept. of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
Larsson, Karin (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Pediatrics, Kristianstad Hospital, Kristianstad, Sweden
Örtqvist, E. (author)
Karolinska Institutet
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Carlsson, Annelie (author)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Dept. of Pediatrics, Malmö, Sweden,Department of Clinical Sciences, Unit of Pediatrics, University Hospital, Lund University, Malmö, Sweden
Cederwall, E. (author)
Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden,Dept. of Pediatrics, Karlskrona, Sweden
Cilio, Corrado (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Dept. of Pediatrics, Jönköping, Sweden,Department of Clinical Sciences, Cellular Autoimmunity Unit, University Hospital, Lund University, Malmö, Sweden
Sjöblad, Sture (author)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Dept. of Pediatrics, Lund, Sweden,Department of Clinical Sciences, Unit of Pediatrics, University Hospital, Lund University, Malmö, Sweden
Jönsson, B. A. (author)
Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden,Dept. of Pediatrics, Örebro, Sweden
Larsson, Helena (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Clinical Sciences, Unit of Pediatrics, University Hospital, Lund University, Malmö, Sweden
Lynch, Kristian (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
Neiderud, Jan (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Dept. of Pediatrics, Helsingborg, Sweden,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
Nilsson, Anna (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden
Sjöblad, S. (author)
Lernmark, Åke (author)
Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC/Lund University, Malmö, Sweden; Department of Medicine, University of Washington, Seattle, WA, USA
Aili, M. (author)
Dept. of Pediatrics, Halmstad, Sweden
Bååth, L. E. (author)
Dept. of Pediatrics, Östersund, Sweden,Dept. of Pediatrics, Mölndal, Sweden
Carlsson, E. (author)
Dept. of Pediatrics, Kalmar, Sweden
Edenwall, H. (author)
Dept. of Pediatrics, Karlskrona, Sweden,Dept. of Pediatrics, Umeå, Sweden
Forsander, Gun, 1951 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
Granstro, B. W. (author)
Dept. of Pediatrics, Gällivare, Sweden
Gustavsson, I. (author)
Dept. of Pediatrics, Skellefteå, Sweden
Hanås, R. (author)
Dept. of Pediatrics, Uddevalla, Sweden
Hellenberg, L. (author)
Dept. of Pediatrics, Nyköping, Sweden
Hellgren, H. (author)
Dept. of Pediatrics, Lidköping, Sweden,Dept. of Pediatrics, Hudiksvall, Sweden
Holmberg, E. (author)
Dept. of Pediatrics, Umeå, Sweden
Hörnell, H. (author)
Dept. of Pediatrics, Hudiksvall, Sweden
Ivarsson, Sten-A. (author)
Dept. of Pediatrics, Malmö, Sweden
Johansson, C. (author)
Dept. of Pediatrics, Jönköping, Sweden
Jonsell, G. (author)
Dept. of Pediatrics, Karlstad, Sweden
Kockum, K. (author)
Dept. of Pediatrics, Ystad, Sweden,Dept. of Pediatrics, Skilstuna, Sweden,Dept. of Pediatrics, Danderyd, Sweden
Lindblad, Birgitta Ejdervik, 1955- (author)
Dept. of Pediatrics, Mölndal, Sweden,Swedish Childhood Diabetes Study Group
Lindh, A. (author)
Dept. of Pediatrics, Borås, Sweden
Ludvigsson, Jonas F., 1969- (author)
Dept. of Pediatrics, Linköping, Sweden,Swedish Childhood Diabetes Study Group
Myrdal, U. (author)
Dept. of Pediatrics, Västerås, Sweden
Neiderud, J. (author)
Dept. of Pediatrics, Helsingborg, Sweden
Segnestam, K. (author)
Dept. of Pediatrics, Skilstuna, Sweden
Sjöblad, S. (author)
Dept. of Pediatrics, Lund, Sweden
Skogsberg, L. (author)
Dept. of Pediatrics, Boden, Sweden
Strömberg, L. (author)
Dept. of Pediatrics, Norrköping, Sweden
Ståhle, U. (author)
Dept. of Pediatrics, Ängelholm, Sweden
Thalme, B. (author)
Dept. of Pediatrics, Huddinge, Sweden
Tullus, K. (author)
Dept. of Pediatrics, Danderyd, Sweden
Tuvemo, Torsten (author)
Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson
Wallensteen, M. (author)
Dept. of Pediatrics, Stockholm, Sweden
Westphal, Otto, 1935 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
Åman, Jan, 1948- (author)
Örebro universitet,Hälsoakademin,Swedish Childhood Diabetes Study Group
Lindblad, Bengt (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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 (creator_code:org_t)
2008-09-04
2008
English.
In: Acta Diabetologica. - : Springer Science and Business Media LLC. - 0940-5429 .- 1432-5233. ; 45:4, s. 231-5
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

HLA-DQ
Genotype
Temporal trends
Age at diagnosis
Autoimmune disease
MEDICINE
MEDICIN
Internal medicine
Diabetology
Invärtesmedicin
HLA-DQ
Genotype
Temporal trends
Age at diagnosis
Autoimmune disease

Publication and Content Type

ref (subject category)
art (subject category)

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