| 1. |
- Stattin, Eva-Lena, et al.
(author)
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A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans
- 2010
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 86:2, s. 126-137
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Journal article (peer-reviewed)abstract
- Osteochondritis dissecans is a disorder in which fragments of articular cartilage and subchondral bone dislodge from the joint surface. We analyzed a five-generation family in which affected members had autosomal-dominant familial osteochondritis dissecans. A genome-wide linkage analysis identified aggrecan (ACAN) as a prime candidate gene for the disorder. Sequence analysis of ACAN revealed heterozygosity for a missense mutation (c.6907G > A) in affected individuals, resulting in a p.V2303M amino acid substitution in the aggrecan G3 domain C-type lectin, which mediates interactions with other proteins in the cartilage extracellular matrix. Binding studies with recombinant mutated and wild-type G3 proteins showed loss of fibulin-1, fibulin-2, and tenascin-R interactions for the V2303M protein. Mass spectrometric analyses of aggrecan purified from patient cartilage verified that V2303M aggrecan is produced and present in the tissue. Our results provide a molecular mechanism for the etiology of familial osteochondritis dissecans and show the importance of the aggrecan C-type lectin interactions for cartilage function in vivo.
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| 2. |
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| 3. |
- Cámara, Fernando, 1967-, et al.
(author)
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Zinkgruvanite, Ba4Mn2+4Fe3+2(Si2O7)2(SO4)2O2(OH)2, a new ericssonite-group mineral from the Zinkgruvan Zn-Pb-Ag-Cu deposit, Askersund, Örebro County, Sweden.
- 2021
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In: European journal of mineralogy. - : Nicolaus Copernicus University Press. - 0935-1221 .- 1617-4011. ; 33:6, s. 659-673
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Journal article (peer-reviewed)abstract
- Zinkgruvanite, ideally Ba4Mn2+4Fe3+2(Si2O7)2(SO4)2O2(OH)2, is a new member of the ericssonite group, found in Ba-rich drill core samples from a sphalerite+galena- and diopside-rich metatuffite succession from the Zinkgruvan mine, Örebro county, Sweden. Zinkgruvanite is associated with massive baryte, barytocalcite, diopside and minor witherite, cerchiaraite-(Al) and sulfide minerals. It occurs as subhedral to euhedral flattened and elongated crystals up to 4 mm. It is almost black, semi-opaque with a dark brown streak. The luster is vitreous to sub-adamantine on crystal faces, resinous on fractures. The mineral is brittle with an uneven fracture. VHN100 = 539 and HMohs ~4½. In thin fragments, it is reddish-black, translucent and optically biaxial (+), 2Vz > 70°. Pleochroism is strong, deep brown-red (E ⊥ {001} cleavage) to olive-pale brown. Chemical point analyses by WDS-EPMA together with iron valencies determined from Mössbauer spectroscopy, yielded the empirical formula (based on 26 O+OH+F+Cl anions): (Ba4.02Na0.03)Σ4.05(Mn1.79Fe2+1.56Fe3+0.42Mg0.14Ca0.10Ni0.01Zn0.01)Σ4.03 (Fe3+1.74Ti0.20Al0.06)Σ2.00Si4(S1.61Si0.32P0.07)Σ1.99O24(OH1.63Cl0.29F0.08)Σ2.00. The mineral is triclinic, space group P–1, with unit-cell parameters a = 5.3982(1) Å, b = 7.0237(1) Å, c = 14.8108(4) Å, α = 98.256(2)º, β = 93.379(2)º, γ = 89.985(2)º and V = 554.75(2) Å3 for Z = 1. The eight strongest X-ray powder diffraction lines are [d Å (I%; hkl)]: 3.508 (70; 103), 2.980(70; 11–4), 2.814 (68; 1–22), 2.777 (70; 121), 2.699 (714; 200), 2.680 (68; 20–1), 2.125 (100; 124, 204), 2.107 (96; –221). The crystal structure (R1 = 0.0379 for 3204 reflections) is an array of TS (titanium silicate) blocks alternating with intermediate blocks. The TS blocks consist of HOH sheets (H = heteropolyhedral, O = octahedral) parallel to (001). In the O sheet, the Mn2+-dominant MO(1,2,3) sites give ideally Mn2+4 pfu. In the H sheet, the Fe3+-dominant MH sites and AP(1) sites give ideally Fe3+2Ba2 pfu. In the intermediate block, SO4 oxyanions and eleven coordinated Ba atoms give ideally 2 × SO4Ba pfu. Zinkgruvanite is related to ericssonite and ferro-ericssonite in having the same topology and type of linkage of layers in the TS block. Zinkgruvanite is also closely compositionally related to yoshimuraite, Ba4Mn4Ti2(Si2O7)2(PO4)2O2(OH)2, via the coupled heterovalent substitution 2 Ti4+ + 2 (PO4)3- →2 Fe3+ + 2 (SO4)2-, but presents a different type of linkage. The new mineral probably formed during a late stage of regional metamorphism of a Ba-enriched, syngenetic protolith, involving locally generated oxidized fluids of high salinity.
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| 4. |
- Landström, Anders, et al.
(author)
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Adaptive Morphological Filtering of Incomplete Data
- 2014
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In: 2013 International Conference on Digital Image Computing: Techniques and Applications (DICTA 2013). - Piscataway, NJ : IEEE Communications Society. - 9781479921263
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Conference paper (peer-reviewed)abstract
- We demonstrate how known convolution techniques for uncertain data can be used to set the shapes of structuring elements in adaptive mathematical morphology, enabling robust morphological processing of partially occluded or otherwise incomplete data. Results are presented for filtering of both gray-scale images containing missing data and 3D profile data where information is missing due to occlusion effects. The latter demonstrates the intended use of the method: enhancement of crack signatures in a surface inspection system for casted steel.The presented method is able to disregard unreliable data in a systematic and robust way, enabling adaptive morphological processing of the available information while avoiding any false edges or other unwanted features introduced by the values of faulty pixels.
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| 5. |
- Landström, Anders, et al.
(author)
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Image reconstruction by prioritized incremental normalized convolution
- 2011
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In: Image analysis. - Berlin : Encyclopedia of Global Archaeology/Springer Verlag. - 9783642212260 ; , s. 176-185
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Conference paper (peer-reviewed)abstract
- A priority-based method for pixel reconstruction and incrementalhole filling in incomplete images and 3D surface data is presented.The method is primarily intended for reconstruction of occluded areasin 3D surfaces and makes use of a novel prioritizing scheme, based on apixelwise defined confidence measure, that determines the order in whichpixels are iteratively reconstructed. The actual reconstruction of individualpixels is performed by interpolation using normalized convolution.The presented approach has been applied to the problem of reconstructing3D surface data of a rock pile as well as randomly sampled imagedata. It is concluded that the method is not optimal in the latter case,but the results show an improvement to ordinary normalized convolutionwhen applied to the rock data and are in this case comparable to thoseobtained from normalized convolution using adaptive neighborhood sizes.
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| 6. |
- Landström, Anders, et al.
(author)
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Sub-millimeter crack detection in casted steel using color photometric stereo
- 2014
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In: 2013 International Conference on Digital Image Computing Techniques and Applications (DICTA 2013. - Piscataway, NJ : IEEE Communications Society. - 9781479921287
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Conference paper (peer-reviewed)abstract
- A novel method for automated inspection of small corner cracks in casted steel is presented, using a photometric stereo setup consisting of two light sources of different colors in conjunction with a line-scan camera. The resulting image is separated into two different reflection patterns which are used to cancel shadow effects and estimate the surface gradient. Statistical methods are used to first segment the image and then provide an estimated crack probability for each segmented region. Results show that true cracks are successfully assigned a high crack probability, while only a minor proportion of other regions cause similar probability values. About 80% of the cracks present in the segmented regions are given a crack probability higher than 70%, while the corresponding number for other non-crack regions is only 5%. The segmented regions contain over 70% of the manually identified crack pixels. We thereby provide proof-of-concept for the presented method.
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| 7. |
- Landström, Anders, et al.
(author)
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Voronoi-based ISD and site density characteristics for mobile networks
- 2012
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In: 2012 IEEE 76th Vehicular Technology Conference. - Piscataway, NJ : IEEE Communications Society. - 9781467318815
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Conference paper (peer-reviewed)abstract
- Inter-Site Distance (ISD) is a common measure for characterizing the site density in a mobile network However, obtaining a good estimation of the ISD for a real world network is not trivial since the physical layout is usually quite more complex than a perfect theoretical hexagonal grid, due to a number of unavoidable factors such as site availability and traffic density. Voronoi diagrams have been suggested for approximating cells from network layouts, providing a method for partitioning the covered area into cells defined by the proximity to the given set of sites. This yields a framework for site coverage approximation based on the actual site distribution, rather than an underlying theoretical model.We present a novel measure, based on Voronoi diagrams, for characterizing the site density of a cellular network and provide a comparison to the more traditional ISD measure. This measure improves capacity assessments and modeling of real networks.
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| 8. |
- Niero, Luisa, et al.
(author)
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The effect of pH, temperature, and inoculum on the fermentation of pulp and paper biosludge: increasing the nutrient availability for rearing of black soldier fly larvae
- 2023
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In: Biomass Conversion and Biorefinery. - : Springer Nature. - 2190-6815 .- 2190-6823. ; 13:18, s. 16685-16693
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Journal article (peer-reviewed)abstract
- Pulp and paper production is one of the largest global industries producing annually 400 million metric tons of pulp and paper products and 6 million tons of pulp and paper biosludge (PPBS). From a resource efficiency and sustainability perspective, there is a need for improving PPBS management. This study assessed fermentation of PPBS as pretreatment to improve PPBS feasibility as feed for black soldier fly larvae. The impact of temperature, pH, and inoculum on the concentration of soluble chemical oxygen demand (sCOD) and volatile fatty acids (VFA) was assessed. An initial pH of 10 and the addition of inoculum from an anaerobic digester substantially increased the concentration of sCOD. The obtained concentration of VFA was low compared to the VFA concentration needed to improve the growth of Black Soldier Fly Larvae (BSFL). The PPBS is recalcitrant to fermentation because of the high content of lignocellulose. Fermentation as done in this study does not convert PPBS to a feasible feed for black soldier fly larvae; thus, further research on improved fermentation is needed. However, fermentation at alkaline pH and addition of inoculum do increase the final pH of PPBS which improves its feasibility as feed for BSFL. Future studies should explore pH > 10 and temperatures > 55 °C to increase sCOD and improving generation of VFA by removal of inhibiting substances, testing other types of inoculum (rumen microorganisms) and co-fermentation.
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| 9. |
- Olofsson, Thomas, et al.
(author)
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Kravhantering, produkt- och projektutveckling av industriella byggkoncept
- 2012
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Reports (other academic/artistic)abstract
- I ett industriellt byggande måste krav och önskemål hanteras i två utvecklingsfaser dels i den normala byggprocessen, s.k. projektutvecklingsfas, dels när det industriella konceptet utvecklas i en separat produktutvecklingsprocess, som är åtskild från byggprocessen. När produktutvecklingsfasen är genomförd, ska den på något sätt paketeras, lanseras, tillämpas och förvaltas. Plattformar och produktfamiljer är begrepp som används för att beskriva utvecklingen av strategier för s.k. "mass customization" i den fasta industrin, d v s sättet att med bibehållen skalfördel i mass-produktionssystem kunna anpassa produkten efter kundens önskemål. Det innebär att ägaren av ett byggkoncept skall utveckla dessa plattformar för projektering, produktion och försörjningskedjor som sedan används i projektutvecklingen av konceptet till färdig byggnad. Alla koncept måste pro-jektutvecklas till viss del, d v s anpassas till platsen. Hur stor del som konceptet specificeras i förväg, d v s i teknik och processutvecklingsskedet styr också i hög grad hur byggprocessen behöver förändras. Dagens utvecklade byggsystem har olika flexibilitet, förtillverkningsgrad och integration av leveran-törskedjor. Vilket innebär att möjlighet till kundanpassning varierar. Det är också viktigt att komma in tidigt i beställarens byggprocess för att kunna erbjuda alternativ som passar. Förutom krav som to-talentreprenad, kan lokala detaljplaner, illustrationsplaner och skisser innefatta krav som kullkastar användande av ett utvecklat koncept. Industriella byggare måste därför utveckla mer geometriskt flexibla byggkoncept än idag så att de bättre kan uppfylla framtida detaljplaners bestämmelser och intentioner. Resultaten från kravhanteringen visar att kravbild och kravnivåer är fragmenterade och olika för olika kravställare. En övervägande del av kraven ska beaktas i projekteringsskedet. Koncept som har hög grad av standardisering så måste byggherren tydligt tjäna tid, pengar och kvalitet på att anstränga sig för att anpassa sitt projekt till plattformen. Kravhantering ersätts i princip med en säljprocess där byggherren/kunden har att ta ställning till ett antal val. Görs oförutsedda avsteg från ett sådant kon-cept förlorar man snabbt vitsen med industrialiseringen. I projektutvecklingen, d v s när konceptet skall anpassas till kund och plats, kan prestanda¬analyser förenklas avsevärt. En stor del av konceptets egenskaper eller indata kommer att vara gemensamt och på förhand känt, d v s endast de egenskaperna som varieras (påverkas av kundanpassningen) behöver definieras. I fallstudien demonstrerades detta med en utvecklad applikation för energianalyser i ett projektutvecklingsskede. Fallstudien med avseende på konceptutveckling av en betongvägg visar att hög energiprestanda och fuktprestanda ej behöver stå i motsats till varandra. Den valda lösningen av de konceptutvecklade betongväggen gav knappt märkbar försämring av fuktprestanda samtidigt som energiprestandan förbättrades väsentligt. Vidare så kunde anslutningen förbättras utan att påverka det arkitektoniska uttrycket. En observation som gjordes i detta arbete var att modularisering med avseende på funktion krävdes. Metodiken som utvecklades i fallstudien lämpar sig mycket väl i ett industriellt byggande baserat på tekniska plattformar där en stor del av de tekniska lösningarna, komponenter och basmoduler är definierade. Vi tror att industrialiserat byggande har en framtid men att det kommer under en lång tid att ske i avgränsade nischer medans de stora förändringarna kommer att ske när dagens platsbyggda flerbo-stadshus övergår till i att allt högre grad baseras på byggsystem och plattformstänkande. En intressant utveckling blir när standardisering av komponenter och processer integreras i plattformar där effektivitetsvinster kan göras i alla led i byggprocessen från projektering och inköp till produktion och montering på plats.
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| 10. |
- Shekhar, Gurmeet, et al.
(author)
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Development of a model for economic control of loading in sublevel caving mines
- 2019
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In: Mining Technology:Transactions of the Institutions of Mining and Metallurgy. - : Taylor & Francis. - 2572-6668 .- 2572-6676. ; 128:2, s. 118-128
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Journal article (peer-reviewed)abstract
- This paper presents an economic model for optimizing loading at the draw point in sublevel caving (SLC) operations. The input data consist of estimated bucket grades based on bucket weights from Load Haul Dump machines. This information, together with average operational mining costs, was used to create an economic model providing a real-time economic assessment of the draw point performance for SLC rings. The results demonstrate the importance of continuous draw point monitoring to optimize SLC operations. The proposed model provides an economic assessment of operating draw points and will help mine personnel to decide when to stop loading from a blasted ring. It can also help mine management understand the complexity of material flow in SLC operations. Finally, it provides operational flexibility for the mine to optimize loading at the draw point by increasing ore recovery while maintaining operational control of draw point performance.
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