SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Jonsson Pernilla) ;hsvcat:3;pers:(Kockum Ingrid)"

Sökning: WFRF:(Jonsson Pernilla) > Medicin och hälsovetenskap > Kockum Ingrid

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Grut, Viktor, et al. (författare)
  • Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis : a presymptomatic case-control study
  • 2021
  • Ingår i: European Journal of Neurology. - : Blackwell Publishing. - 1351-5101 .- 1468-1331. ; 28:9, s. 3072-3079
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Epstein-Barr virus (EBV) and Human herpesvirus 6A (HHV-6A) are associated with increased risk of multiple sclerosis (MS). Conversely, infection with Cytomegalovirus (CMV) has been suggested to reduce the risk of MS but supporting data from presymptomatic studies are lacking. Here, we sought to increase the understanding of CMV in MS aetiology.METHODS: We performed a nested case-control study with presymptomatically collected blood samples identified through cross-linkage of MS registries and Swedish biobanks. Serological antibody response against CMV, EBV and HHV-6A was determined using a bead-based multiplex assay. Odds ratio (OR) with 95 % confidence intervals (CI) for CMV seropositivity as risk factor for MS was calculated by conditional logistic regression and adjusted for EBV and HHV-6A seropositivity. Potential interactions on the additive scale were analysed by calculating attributable proportion due to interaction (AP).RESULTS: Serum samples from 670 pairs of matched cases and controls were included. CMV seropositivity was associated with a reduced risk for MS (OR = 0.70, 95% CI 0.56-0.88, p = 0.003). Statistical interactions on the additive scale were observed between seronegativity for CMV and seropositivity against HHV-6A (AP 0.34, 95% CI 0.06-0.61) and EBV antigen EBNA-1 (amino acid 385-420) at age 20-39 years (AP 0.37, 95% CI 0.09-0.65).CONCLUSIONS: CMV seropositivity is associated with a decreased risk for MS. The protective role for CMV infection in MS aetiology is further supported by the interactions between CMV seronegativity and EBV and HHV-6A seropositivity.
  •  
2.
  • Oddsson, Asmundur, et al. (författare)
  • Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality
  • 2023
  • Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygosity among 1.52 million individuals from six European populations. In this study, we identified 25 genes harboring protein-altering sequence variants with a strong deficit of homozygosity (10% or less of predicted homozygotes). Sequence variants in 12 of the genes cause Mendelian disease under a recessive mode of inheritance, two under a dominant mode, but variants in the remaining 11 have not been reported to cause disease. Sequence variants with a strong deficit of homozygosity are over-represented among genes essential for growth of human cell lines and genes orthologous to mouse genes known to affect viability. The function of these genes gives insight into the genetics of intrauterine lethality. We also identified 1077 genes with homozygous predicted loss-of-function genotypes not previously described, bringing the total set of genes completely knocked out in humans to 4785.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Olsson, Tomas (2)
Thorsteinsdottir, Un ... (2)
Kockum, Ingrid (2)Ta bort avgränsningen
Andreassen, Ole A (1)
Klareskog, Lars (1)
Alfredsson, Lars (1)
visa fler...
Andersen, Oluf, 1941 (1)
Lopez de Lapuente Po ... (1)
Halldorsson, Gisli H ... (1)
Jonsdottir, Ingileif (1)
Rafnar, Thorunn (1)
Stefansson, Kari (1)
Hjalgrim, Henrik (1)
Lindam, Anna, PhD, 1 ... (1)
Padyukov, Leonid (1)
Rantapää-Dahlqvist, ... (1)
Haavik, Jan (1)
Tryggvadottir, Laufe ... (1)
Banasik, Karina (1)
Brunak, Søren (1)
Djurovic, Srdjan (1)
Alonso Magdalena, Lu ... (1)
Sundström, Peter (1)
Askling, Johan (1)
Fogdell-Hahn, Anna (1)
Gunnarsson, Martin, ... (1)
Salzer, Jonatan (1)
Sulem, Patrick (1)
Helgason, Agnar (1)
Gudbjartsson, Daniel (1)
Waterboer, Tim (1)
Erikstrup, Christian (1)
Bergström, Tomas (1)
Jensson, Brynjar O. (1)
Stefánsson, Hreinn (1)
Tragante, Vinicius (1)
Holm, Hilma (1)
Daly, Mark (1)
Westergaard, David (1)
Nyegaard, Mette (1)
Pedersen, Ole Birger (1)
Nielsen, Henriette S ... (1)
Brunak, Soren (1)
Gustafsson, Rasmus (1)
Steinthorsdottir, Va ... (1)
Biström, Martin, 198 ... (1)
Huang, Jesse (1)
Brenner, Nicole (1)
Butt, Julia (1)
Vrethem, Magnus (1)
visa färre...
Lärosäte
Umeå universitet (2)
Karolinska Institutet (2)
Göteborgs universitet (1)
Örebro universitet (1)
Linköpings universitet (1)
Lunds universitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)Ta bort avgränsningen

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy