| 1. |
- Aman, Robert, 1982-
(författare)
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Impossible Interculturality? : Education and the Colonial Difference in a Multicultural World
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- An increasing number of educational policies, academic studies, and university courses today propagate ‘interculturality’ as a method for approaching ‘the Other’ and reconciling universal values and cultural specificities. Based on a thorough discussion of Europe’s colonial past and the hierarchies of knowledge that colonialism established, this dissertation interrogates the definitions of intercultural knowledge put forth by EU policy discourse, academic textbooks on interculturality, and students who have completed a university course on the subject. Taking a decolonial approach that makes its central concern the ways in which differences are formed and sustained through references to cultural identities, this study shows that interculturality, as defined in these texts, runs the risk of affirming a singular European outlook on the world, and of elevating this outlook into a universal law. Contrary to its selfproclaimed goal of learning from the Other, interculturality may in fact contribute to the repression of the Other by silencing those who are already muted. The dissertation suggests an alternative definition of interculturality, which is not framed in terms of cultural differences but in terms of colonial difference. This argument is substantiated by an analysis of the Latin American concept of interculturalidad, which derives from the struggles for public and political recognition among indigenous social movements in Bolivia, Ecuador and Peru. By bringing interculturalidad into the picture, with its roots in the particular and with strong reverberations of the historical experience of colonialism, this study explores the possibility of decentring the discourse of interculturality and its Eurocentric outlook. In this way, the dissertation argues that an emancipation from colonial legacies requires that we start seeing interculturality as inter-epistemic rather than simply inter-cultural.
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| 2. |
- Bomark, Niklas, 1984-
(författare)
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Drawing Lines in the Sand : Organizational Responses to Evaluations in a Swedish University
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- As organizations are increasingly evaluated, evaluative practices are becoming central to organization theory. While highlighting how organizations may respond to evaluations, earlier work on organizations and evaluation has been limited to inter-organizational evaluations, such as third-party rankings or ratings. As a consequence, the prevailing perspective on organizational responses has been developed almost entirely based on an idea that what is being evaluated in the first place – the evaluation entities – is unproblematic. Acknowledging that the definition of the evaluation entity may be ambiguous prior to the evaluation, and that this definition might vary over time, some interesting areas of inquiry emerge in relation to current understandings of organizational responses to evaluations.First, it raises questions of how entities are defined in evaluations, and how this can be seen as an organizational response? Second, it raises questions about our current understanding of the dynamics of organizational responses and how organizational responses shape organizational adaptation and change. Third, it raises question about how entity definitions shape how organizations become evaluated. Despite recent interest in understanding organizational responses to evaluations, organizational scholars have largely refrained from entertaining these questions.The objective of this dissertation is to revisit the assumption of the unambiguously defined evaluation entity in the current theorizing on organizational responses to evaluations. An opportunity to investigate this question emerged when the oldest university in Sweden, Uppsala University, decided to carry out two large evaluations of the research activities within the university – in 2007 and in 2011. The evaluation was made public and aimed to identify and evaluate (partly through a rating) the research achievements of the departments of the university. This presented an opportunity to study organizational responses to evaluations in a setting that is different from what has been studied previously. Based on a study of 44 of the departments within the university my main finding show how entities are defined and how this can be seen as an organizational response to evaluations. My findings also show how entity definitions interact with the more traditional responses taken after an evaluation, and that entity definitions shape the evaluation of the department. This dissertation thus lends support for the idea that apart from responding by changing activities or their organizational units, organizations can also respond to evaluations by the way they shape what will be evaluated – the entities being subject for the evaluation. The findings in this dissertation holds consequences for organizational theory and the evaluation of organizations.
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| 3. |
- Borgmästars, Emmy, 1990-
(författare)
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In search of early biomarkers in pancreatic ductal adenocarcinoma using multi-omics and bioinformatics
- 2022
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive malignancy with a 5-year survival of 10 %. Surgery is the only curative treatment. Unfortunately, few patients are eligible for surgery due to late detection. Thus, we need ways to detect the disease at an earlier stage and for that good screening biomarkers could be used. Previous studies have analyzed circulating analytes in prospective studies to identify early PDAC signals. One such class is microRNAs (miRNAs). MicroRNAs are non-coding RNAs of around 22 nucleotides that act as post- transcriptional regulators by interaction with messenger RNAs (mRNAs). The function of a miRNA can be elucidated by target prediction, to identify its potential targets, followed by enrichment analysis of the predicted targets. Challenges with this approach includes a lot of false positives being generated and that miRNAs can perform their role in a tissue- or disease-specific manner. Other classes of analytes that have previously been studied in prospective PDAC cohorts are metabolites and proteins. Aims: This thesis has three aims. First, to build a miRNA functional analysis pipeline with correlation support between miRNA and its predicted target genes. Second, to identify potential circulating biomarkers for early detection of PDAC using multi-omics. Third, to identify potential prognostic metabolites in a prospective PDAC cohort.Methods: We used publicly available data from the cancer genome atlas-pancreatic adenocarcinoma (TCGA-PAAD) and pre-diagnostic plasma samples from the Northern Sweden Health and Disease Study. We built a pipeline in R including miRNA, mRNA, and protein expression data from TCGA-PAAD for in silico miRNA functional analysis. Pre- diagnostic plasma samples from future PDAC patients as well as matched healthy controls were analyzed using multi- omics. Tissue polypeptide specific antigen (TPS) was analyzed by enzyme linked immunosorbent assay in 267 future PDAC samples and 320 healthy controls. Metabolomics and clinical biomarkers (carbohydrate antigen (CA) 19-9, carcinoembryonic antigen (CEA), and CA 15-3) were profiled in 100 future PDAC samples and 100 healthy controls using liquid chromatography-mass spectrometry (MS), gas chromatography-MS, and multi-plex technology. Of these, a subset of 39 future PDAC patients and 39 healthy controls were profiled for 2083 microRNAs using targeted sequencing and 644 proteins using proximity extension assays. Circulating levels of multi-omics analytes were analyzed using conditional or unconditional logistic regression. Least absolute shrinkage and selection operator (LASSO) in combination with 500 bootstrap iterations identified the most informative variables. The prognostic value of metabolites was assessed using cox regression. Multi-omics factor analysis (MOFA) and data integration analysis for biomarker discovery using latent components (DIABLO) were used for multi-omics integration analyses.Results: An automated pipeline was built consisting of 1) miRNA target prediction, 2) correlation analyses between miRNA and its targets on mRNA and protein expression levels, and 3) functional enrichment of correlated targets to identify enriched Kyoto encyclopedia of genes and genomes (KEGG) pathways and gene ontology (GO) terms for a specific miRNA. The pipeline was run for all microRNAs (~700) detected in the TCGA-PAAD cohort. These results can be downloaded from a shiny app (https://emmbor.shinyapps.io/mirfa/). TPS was not altered in pre-diagnostic PDAC patients up to 24 years prior to diagnosis, but increased at diagnosis (OR = 1.03, 95 % CI: 1.01-1.05). Internal area under curves of 0.74, 0.80, and 0.88 were achieved for five metabolites, two proteins, and two miRNAs that were selected by LASSO and bootstrap iterations, in combination with CA 19-9. Neither MOFA nor DIABLO separated well between future PDAC cases and healthy controls. Conclusions: Our bioinformatics pipeline for in silico functional analysis of microRNAs successfully identifies enriched KEGG pathways and GO terms for miRNA isoforms. The investigated plasma samples are heterogeneous, but among the analyzed variables, we identified five metabolites, two proteins, and two microRNAs with highest potential for early PDAC detection. CA 19-9 levels increased closer to diagnosis. We identified five fatty acids that could be studied in a diagnostic PDAC cohort as prognostic biomarkers.
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| 4. |
- Byström, Roberth, 1971-
(författare)
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SOD1´s Law : An Investigation of ALS Provoking Properties in SOD1
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Proteins are the most important molecules in the cell since they take care of most of the biological functions which resemble life. To ensure that everything is working properly the cell has a rigorous control system to monitor the proper function of its proteins and sends old or dysfunctional proteins for degradation. Unfortunately, this system sometimes fails and the once so vital proteins start to misbehave or to accumulate and in the worst case scenario these undesired processes cause the death of their host. One example is Amyotrophic Lateral Sclerosis (ALS); a progressive and always fatal neurodegenerative disorder that is proposed to derive from accumulation of aberrant proteins. Over 140 mutations in the human gene encoding the cytosolic homodimeric enzyme Cu/Zn-Superoxide Dismutase (SOD1) are linked to ALS. The key event in SOD1 associated ALS seems to be the pathological formation of toxic protein aggregates as a result of initially unfolded or partly structured SOD1-mutants. Here, we have compared the folding behaviour of a set of ALS associated SOD1 mutants. Based on our findings we propose that SOD1 mediated ALS can be triggered by a decrease in protein stability but also by mutations which reduce the net charge of the protein. Both findings are in good agreement with the hypothesis for protein aggregation. SOD1 has also been found to be able to interact with mitochondrial membranes and SOD1 inclusions have been detected in the inter-membrane space of mitochondria originating from the spinal cord. The obvious question then arose; does the misfolding and aggregation of SOD1 involve erroneous interactions with membranes? Here, we could show that there is an electrostatically driven interaction between the reduced apo SOD1 protein including ALS associated SOD1-mutants and charged lipid membrane surfaces. This association process changes the secondary structures of these mutants in a way quite different from the situation found in membrane free aqueous environment. However, the result show that mutants interact with charged lipid vesicles to lesser extent than wildtype SOD1. This opposes the correlation between decreased SOD1 stability and disease progression. We therefore suggest that the observed interaction is not a primary cause in the ALS mechanism.
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| 5. |
- Bäcke, Linda, 1977-
(författare)
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Modeling the Microstructural Evolution during Hot Deformation of Microalloyed Steels
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis contains the development of a physically-based model describing the microstructural evolution during hot deformation of microalloyed steels. The work is mainly focused on the recrystallization kinetics. During hot rolling, the repeated deformation and recrystallization provides progressively refined recrystallized grains. Also, recrystallization enables the material to be deformed more easily and knowledge of the recrystallization kinetics is important in order to predict the required roll forces. Hot strip rolling is generally conducted in a reversing roughing mill followed by a continuous finishing mill. During rolling in the roughing mill the temperature is high and complete recrystallization should occur between passes. In the finishing mill the temperature is lower which means slower recrystallization kinetics and partial or no recrystallization often occurs. If microalloying elements such as Nb, Ti or V are present, the recrystallization can be further retarded by either solute drag or particle pinning. When recrystallization is completely retarded and strain is accumulated between passes, the austenite grains will be severely deformed, i.e. pancaking occurs. Pancaking of the grains provides larger amount of nucleation sites for ferrite grains upon transformation and hence a finer ferrite grain size is achieved. In this work a physically-based model has been used to describe the microstructural evolution of austenite. The model is built-up by several sub-models describing dislocation density evolution, recrystallization, grain growth and precipitation. It is based on dislocation density theory where the generated dislocations during deformation provide the driving force for recrystallization. In the model, subgrains act as nuclei for recrystallization and the condition for recrystallization to start is that the subgrains reach a critical size and configuration. The retarding effect due to elements in solution and as precipitated particles is accounted for in the model. To verify and validate the model axisymmetric compression tests combined with relaxation were modeled and the results were compared with experimental data. The precipitation sub-model was verified by the use of literature data. In addition, rolling in the hot strip mill was modeled using process data from the hot strip mill at SSAB Strip Products Division. The materials investigated were plain C-Mn steels and Nb microalloyed steels. The results from the model show good agreement with measured data.
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| 6. |
- Ekström, Madeleine, 1984-
(författare)
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Oxidation and corrosion fatigue aspects of cast exhaust manifolds
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Emission regulations for heavy-duty diesel engines are becoming increasingly restrictive to limit the environmental impacts of exhaust gases and particles. Increasing the specific power output of diesel engines would improve fuel efficiency and greatly reduce emissions, but these changes could lead to increased exhaust gas temperature, increasing demands on the exhaust manifold material. This is currently the ferritic ductile cast iron alloy SiMo51, containing about 4 wt% Si and ~1 wt% Mo, which operates close to its fatigue and oxidation resistance limits at peak temperature (750C). To ensure high durability at higher temperatures, three different approaches to improving the life of exhaust manifolds were developed in this thesis.The first approach was to modify SiMo51 by adding different combinations of Cr and Ni to improve its high-temperature strength and oxidation resistance, or by applying a thermal barrier coating (TBC) to reduce the material temperature and thereby improve fatigue life. In the second approach, new materials for engine components, e.g. austenitic ductile iron and cast stainless steel, were investigated for their high-temperature fatigue and oxidation properties. In order to identify the most suitable alloys for this application, in the third the environmental effects of the corrosive diesel exhaust gas on the fatigue life of SiMo51 were investigated.The high-temperature oxidation resistance of SiMo51 at 700 and 800C in air was found to be improved by adding Cr, whereas Ni showed adverse effects. The effects of solid-solution hardening from Ni and precipitation hardening from Cr were low at 700C, with improvements only at lower temperatures. Applying a TBC system, providing thermal protection from a ceramic topcoat and oxidation protection from a metallic bond coat, resulted in only small reductions in material temperature, but according to finite element calculations still effectively improved the fatigue life of a turbo manifold. Possible alternative materials to SiMo51 identified were austenitic cast ductile iron Ni-resistant D5S and austenitic cast stainless steel HK30, which provided high durability of exhaust manifolds up to 800 and 900C, respectively. Corrosion fatigue testing of SiMo51 at 700C in diesel exhaust gas demonstrated that the corrosive gas reduced fatigue life by 30-50% compared with air and by 60-75% compared with an inert environment. The reduced fatigue life was associated with a mechanism whereby the crack tip oxidized, followed by crack growth. Thus another potential benefit of TBC systems is that the bond coat may reduce oxidation interactions and further improve fatigue life.These results can be used for selecting materials for exhaust applications. They also reveal many new research questions for future studies. Combining the different approaches of alloy modification, new material testing and improving the performance using coatings widened the scope of how component life in exhaust manifolds can be improved. Moreover, the findings on environmental interactions on SiMo51 fatigue provide a completely new understanding of these processes in ductile irons, important knowledge when designing components exposed to corrosive environments. The novel facility developed for high-temperature corrosion fatigue testing can be useful to other researchers working in this field.
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| 7. |
- Foultier, Christophe, 1972-
(författare)
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Regimes of Hospitality : Urban Citizenship between Participation and Securitization – the Case of the Multiethnic French Banlieue
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis analyzes various local development policies in Europe’s big urban areas. Striving to understand the respective places accorded to the measures to increase the participation of the inhabitants on the one hand, and to improve for security and public peace in the context of social and territorial policies on the other, I examine how urban policies define models of urban citizenship. The empirical work concerns two sites in the greater metropolitan area of Paris, Le Franc-Moisin–Bel-Air in Saint-Denis and Les Cinq Quartiers in Les Mureaux. It consists of an analysis of public documents as well as a series of interviews and observations. This methodological approach serves to gain an understanding of how participative and security procedures emerge in the history of French urban policy and how these norms interact locally.By investigating the overlap of security politics and participatory devices, I demonstrate that deprived areas do not have access to an adequate form of intervention to meet the expectations and needs of its inhabitants, who are squeezed between a logic of development reluctantly accepted by, but rarely negotiated with its inhabitants, and a logic of security that often leads to the confinement of residents to their respective areas. The thesis thus demonstrates how institutional interventions in multiethnic areas can fuel feelings of suspicion be-tween local stakeholders and civic distrust. Indeed, the participatory procedures that are developed in urban strategies influence the conduct of participants on matters of identity and belonging and can intensify socio-ethnic stigmatization. This effect provides me with a critical standpoint on new techniques of government. The local partners of the state develop daily routines in urban strategies that contribute to articulating participatory devices and security procedures. I claim that the results from this process are “regimes of hospitality”.
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| 8. |
- Gilligan, Melanie, 1979-
(författare)
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Treating the Abstract of Capital Concretely: Films Against Capitalism
- 2022
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)abstract
- This practice-based PhD, Treating the Abstract of Capital Concretely: Films Against Capitalism, looks at how film can oppose the prevailing ideasof capitalist systems.The research asks: What qualities do films have that can be used as strategies against capitalism and what knowledge do these films produce? In an understanding that capitalism projects concepts onto the world, and that mainstream film can frame people’s lives through a reductive capitalist understanding, the research suggests that more politically powerful moving images need to be the focus to create societal change.Treating the Abstract of Capitalism Concretely: Films Against Capitalism, includes six aesthetic, political and conceptual video works, and an accompanying written handbook, that together consider capital as the relation between abstract laws of accumulation and concrete lived situations.Making moving image works against the capitalist system necessarily involves knowledge about capitalism, however, the research charts how the knowledge most central in filmmaking is often associative, affective and combines knowledge with practice. A variety of methodological approaches are pursued through practical and theoretical research about how films can oppose capitalism. This investigation is explored materially, through video projects that interrogate capitalist abstraction from inside social processes,in realities that people live. The video works present a critique of racial and patriarchal capitalism, while the written component presents a contextual discussion about films against capitalism.The PhD submission consists of six video projects: The Common Sense, The Bay Area Protests, Parts-wholes 2, Crowds, Home Together, and Health as Individual vs. Health as Social and a PDF handbook, Treating the Abstractof Capital Concretely: Films Against Capitalism. The written text puts forth theoretical and practical proposals for films against capitalism as well as a 3 script. Connections are here made between different understandings of abstraction, while bringing in ideas from political theory, as well as demonstrating allegory as a technique against capitalism in film.The video works and handbook are accessed via: https://www.films-against-capitalism.com
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| 9. |
- Grafström, Maria, 1978-
(författare)
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The Development of Swedish Business Journalism : Historical Roots of an Organisational Field
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Contemporary Swedish business journalism is an established organisational field with shared practice within and across organisations. Using a historical perspective, this dissertation investigates the early formation of this field and the formation of a shared meaning system for business journalism. Addressing the question of how and why the field emerged, the study contributes to institutional approaches in organisational analysis and theories about field development. Drawing on a qualitative longitudinal study, the analysis explores the source of today’s field of business journalism and examines the individuals, organisations, and activities that, during the 1960s and 1970s, laid the groundwork for subsequent field development. Five Swedish newspaper organisations are examined in detail: two business weeklies, Affärsvärlden and Veckans Affärer; the business daily, Dagens industri; and two general dailies, Dagens Nyheter and Svenska Dagbladet. In particular, the study analyses the competencies that was considered necessary for producing business news; the models that functioned as positive examples for business journalists; and the accepted ways of selecting and presenting business news. The study concludes that nascent field formation developed through institutional entrepreneurial processes in the interplay among individuals, organisations, and societal developments. As individuals carried institutional logics from their previous affiliations in business or journalism, they contributed to the nascent field formation – not by breaking with their past, but by continuing, in a new setting, previous ways of approaching their work. The two institutional logics of business and journalism also permeated the newspaper organisations in which these individuals were active. The organisations functioned as platforms that enabled the early practice while setting boundaries for its development. The results suggest that fields develop incrementally and that institutional entrepreneurial processes embody greater continuity and stability than previous research in the area has suggested.
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| 10. |
- Guyard, Carina
(författare)
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Kommunikationsarbete på distans
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This research thesis analyzes the characteristics of communication work in a call centre, by examining the communication work at a Swedish call centre which is outsourced to Latvia. The thesis studies the ways in which communication with the customers is organized, carried out and assigned meaning. Theoretically, the thesis draws on both critical and management-oriented perspectives of work. The empirical investigation combines participant observations at the call centre with individual interviews, mainly conducted with operators and management staff.The communication work is analyzed both as labour and as communicative activity. The concept of labour focuses upon the relation between employer and employee. Therefore, the analysis is placed within the framework of a capitalistic production system, through a survey of the economic and the organisational working conditions. The communicative activity deals with how the telephone conversations with the customers are enacted. In that part of the analyses, the working routines and the meaning making practices are illuminated.As examined in the current research, the communication work is indeed constructed in an alienated manner, through high levels of standardization, immobility, and estrangement from both customers and the customers’ culture. Nonetheless, merely being employed has meant significant economic security for the operators of the Latvian call centre. The operators are incumbents of a society affected by deep economic crises with high unemployment rates. In relation to their broader society, the employees have found meaning within their immediate social situation. This may explain why they endure the monotonous work with few opportunities for development.
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